Results 211 to 220 of about 79,611 (233)

Apoptosis inducing effect of meisoindigo on K562 cells

Chinese Journal of Integrated Traditional and Western Medicine, 1999
To study the effect of meisoindigo on human chronic myelogenous leukemia (CML) cell line K562 cells for exploring the mechanism of meisoindigo in treatment of CML.Multiple methods, including dose-response curve, trypan blue exclusion, cytomorphology, DNA electrophoresis, flow cytometry and TUNEL (TdT mediated dUTP nick and labeling), were used to ...
L, Song, L, Qian
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Expression profile of Notch‐related genes in multidrug resistant K562/A02 cells compared with parental K562 cells

International Journal of Laboratory Hematology, 2010
SummaryDrug resistance is the major setback of acute myeloid leukemia (AML) therapy. Notch proteins have demonstrated functional regulation in cell proliferation, differentiation, and apoptosis and thus may affect drug resistance. Our study aimed to identify the Notch‐related gene profile in drug‐resistant AML cells and provide potential strategies for
S, Yan, D, Ma, M, Ji, D, Guo, J, Dai, P, Zhao, C, Ji   +6 more
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Effects of inducers of erythroid differentiation of human leukemia K562 cells on vincristine-resistant K562/VCR cells

Leukemia Research, 1983
K562/VCR cells, which are resistant to the cytotoxicity of vincristine, were isolated from human erythroleukemia K562 cells. Various compounds that induce erythroid differentiation of K562 cells were tested on K562/VCR cells. Differentiation of K562/VCR cells was not induced by actinomycin D or adriamycin alone, but the resistance of these cells to the
J, Okabe-Kado, M, Hayashi, Y, Honma, M, Hozumi, T, Tsuruo   +4 more
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Expression of C antigen in transduced K562 cells

Transfusion, 2001
BACKGROUND: The Rh blood group system is involved in HDN and transfusion reactions. A retrovirus‐expression system was previously used to show that polypeptides carrying the Rh blood group antigens are encoded by the RHD and RHCE genes. This study investigated the structure of the C antigen.STUDY DESIGN AND METHODS: K562 cells were transduced with full‐
J S, Smythe, D J, Anstee
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[Screening for drug resistance related microRNAs in K562 and K562/A02 cell lines].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2016
To explore the relationship between microRNA and drug resistance in leukemia treatment by screening and identifying the microRNAs which differentially express in K562 cell line and its adriamycin resistant cells-K562/A02 cell line.The drug resistance potency of K562/A02 cells was evaluated by MTT assay.
Yi-Xiong, Cao, Chong-Wen, Dai, Guang-Sen, Zhang   +2 more
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c-Jun binding site identification in K562 cells

Journal of Genetics and Genomics, 2011
Determining the binding sites of the transcription factor is important for understanding of transcriptional regulation. Transcription factor c-Jun plays an important role in cell growth, differentiation and development, but the binding sites and the target genes are not clearly defined in the whole human genome.
Minli, Li, Qinyu, Ge, Wei, Wang, Jinke, Wang, Zuhong, Lu   +4 more
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Reduction of extracellular dehydroascorbic acid by K562 cells

Cell Biochemistry and Function, 1996
AbstractK562 erythroleukaemic cells produced ascorbate when incubated with dehydroascorbic acid. The reduction depended on the number of cells and on the concentration of dehydroascorbic acid. The observed rate consists of a high affinity (apparent) Km 7 μM, Vmax 3·25 pmol min−1 (106 cells)−1 and a low affinity component, which was non‐saturable up to ...
E, Schweinzer, Y, Mao, P, Krajnik, N, Getoff, H, Goldenberg   +4 more
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Spontaneous Cytotoxic Earthworm Leukocytes Kill K562 Tumor Cells

Zoological Science, 1995
Earthworm coelomocytes may act as effector cells which destroy targets in vitro. In a 51Cr release assay, Lumbricus coelomocyte effectors showed lytic activities of 3-14% against K562 human tumor cells when incubated 1-4 hr at 23 degrees C or 37 degrees C. Cytotoxicity was correlated with effector: target ratio.
M M, Suzuki, E L, Cooper
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Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells

Leukemia Research, 1984
The human proerythroblastic leukemia cell-line K562 was induced to differentiate into megakaryocytic cells by 12-O-tetradecanoylphorbol-13-acetate (TPA). Megakaryocytic differentiation was detected when lineage-specific monoclonal antibodies were used to monitor the effect of TPA on K562 cells. A monoclonal anti-platelet antibody (C17) directed against
P A, Tetteroo, F, Massaro, A, Mulder, R, Schreuder-van Gelder, A E, von dem Borne   +4 more
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Persistent infection of K562 cells by encephalomyocarditis virus

Journal of Virology, 1990
Infection of human erythroleukemic K562 cells by encephalomyocarditis virus readily resulted in establishment of persistently infected cultures. In contrast to the usual typical lytic infection by encephalomyocarditis virus, in which trypan blue staining of cells reaches close to 100% by about 15 h postinfection, K562 cell cultures required 3 to 4 days
I U, Pardoe, K K, Grewal, M P, Baldeh, J, Hamid, A T, Burness   +4 more
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