Results 91 to 100 of about 352,958 (260)

Solar Cycle Variations in Ice Acidity at the End of the Last Ice Age: Possible Marker of a Climatically Significant Interstellar Dust Incursion [PDF]

Planetary and Space Science, 2005, vol. 53 no. 4, pages 385 - 393, 2005
Hammer et al. [1997] report the presence of regularly spaced acidity peaks (H+, F-, Cl-) in the Byrd Station, Antarctica ice core. The event has a duration of about one century and falls at the beginning of the deglacial warming. Volcanism appears to be an unlikely cause since the total acid deposition of this event was about 18 fold greater than the ...
arxiv   +1 more source

Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.

Biological and Pharmaceutical Bulletin, 2011
Gastric proton pump (H⁺, K⁺-ATPase) secretes H⁺ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl⁻- and K⁺-transporting proteins are required.
Takuto Fujii, Kyosuke Fujita, N. Takeguchi, H. Sakai   +3 more
semanticscholar   +1 more source

Investigation of left ventricular ejection fraction in a Swiss heart failure population: Insights into mortality and sex differences

ESC Heart Failure, EarlyView.
Graphical representation of main findings and article highlights. Abstract Aims Understanding heart failure (HF) characteristics is essential to improve patient outcomes. Categorizing HF beyond left ventricular ejection fraction (LVEF) is challenging due to heterogeneous clinical presentation and aetiologies.
Rubén Fuentes Artiles, Renald Meçani, Taulant Muka, Lukas Hunziker, Lukas Capék   +4 more
wiley   +1 more source

Heterologous Expression of Aedes aegypti Cation Chloride Cotransporter 2 (aeCCC2) in Xenopus laevis Oocytes Induces an Enigmatic Na+/Li+ Conductance

Insects, 2019
The yellow fever mosquito Aedes aegypti possesses three genes encoding putative Na+-coupled cation chloride cotransporters (CCCs): aeNKCC1, aeCCC2, and aeCCC3. To date, none of the aeCCCs have been functionally characterized.
Megha Kalsi, Christopher Gillen, Peter M. Piermarini   +2 more
doaj   +1 more source

GABA regulates the multidirectional tangential migration of GABAergic interneurons in living neonatal mice. [PDF]

PLoS ONE, 2011
Cortical GABAergic interneurons originate from ganglionic eminences and tangentially migrate into the cortical plate at early developmental stages.
Hiroyuki Inada, Miho Watanabe, Taku Uchida, Hitoshi Ishibashi, Hiroaki Wake, Tomomi Nemoto, Yuchio Yanagawa, Atsuo Fukuda, Junichi Nabekura   +8 more
doaj   +1 more source

Early administration of SGLT2 inhibitors in hospitalized patients: A practical guidance from the current evidence

ESC Heart Failure, EarlyView.
Abstract Sodium‐glucose cotransporter‐2 (SGLT2) inhibitors represent one of the main cornerstones of heart failure treatment. Nevertheless, while the cardiovascular beneficial effects of these drugs have been clearly demonstrated by several clinical trials, in clinical practice, it remains challenging to identify the appropriate timing to start SGLT2 ...
Ruggero Mazzotta, Manuel Garofalo, Samuele Salvi, Matteo Orlandi, Gianluca Marcaccini, Pietro Susini, Luca Checchi, Alberto Palazzuoli, Carlo Di Mario, Maurizio Pieroni, Matteo Beltrami   +10 more
wiley   +1 more source

Chemical crosslinking studies with the mouse Kcc1 K–Cl cotransporter [PDF]

Blood Cells, Molecules, and Diseases, 2009
Oligomerization, function, and regulation of unmodified mouse Kcc1 K-Cl cotransporter were studied by chemical crosslinking. Treatment of Xenopus oocytes and 293T cells expressing K-Cl cotransporter Kcc1 with several types of chemical cross-linkers shifted Kcc1 polypeptide to higher molecular weight forms. More extensive studies were performed with the
Alexander S. Zolotarev, Alexander S. Zolotarev, Alan K. Stuart-Tilley, Sabine Wilhelm, Sabina Casula, Carlo Brugnara, Carlo Brugnara, Boris E. Shmukler, Seth L. Alper, Seth L. Alper   +9 more
openaire   +3 more sources

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.

Proceedings of the National Academy of Sciences of the United States of America, 2005
WNK1 and WNK4 [WNK, with no lysine (K)] are serine-threonine kinases that function as molecular switches, eliciting coordinated effects on diverse ion transport pathways to maintain homeostasis during physiological perturbation.
J. Rinehart, K. Kahle, Paola de los Heros, N. Vázquez, Patricia Meade, F. H. Wilson, S. Hebert, I. Giménez, G. Gamba, R. Lifton   +9 more
semanticscholar   +1 more source

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2 [PDF]

Frontiers in Cellular Neuroscience, 2014
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl(-))-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl(-) concentration ([Cl(-)]i). Lowering [Cl(-)]i enhances inhibition, whereas raising [Cl(-)]i facilitates neuronal activity.
Pavel Uvarov, Igor Medina, Igor Medina, Claudio Rivera, Claudio Rivera, Claudio Rivera, Nazim Kourdougli, Nazim Kourdougli, Christophe Pellegrino, Christophe Pellegrino, Kristopher T. Kahle, Kristopher T. Kahle, Perrine Friedel, Perrine Friedel   +13 more
openaire   +6 more sources

Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility in murine heart failure

European Journal of Heart Failure, EarlyView.
Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility. Abstract Aims Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood.
Suzanne Nathalie Voorrips, Constantin Laurent Palm, Huitzilihuitl Saucedo‐Orozco, Belend Mahmoud, Elisabeth Marloes Schouten, Anna M. Feringa, Pablo I. Sanchez‐Aguilera, Kirsten T. Nijholt, Salva R. Yurista, Peter van der Meer, Herman H.W. Silljé, B. Daan Westenbrink   +11 more
wiley   +1 more source