Results 91 to 100 of about 6,975 (268)

A noninvasive optical approach for assessing chloride extrusion activity of the K-Cl cotransporter KCC2 in neuronal cells [PDF]

, 2017
Background: Cation-chloride cotransporters (CCCs) are indispensable for maintaining chloride homeostasis in multiple cell types, but K-Cl cotransporter KCC2 is the only CCC member with an exclusively neuronal expression in mammals.
Ludwig, Anastasia, Rivera Baeza, Claudio, Uvarov, Pavel   +2 more
core   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Across species: A comparative perspective on red cell homeostasis and its influence on our understanding of human physiology and disease

British Journal of Haematology, EarlyView.
This review highlights how studies on animal red cells have enriched our understanding of the behaviour of those from humans. A comparative perspective has enhanced our knowledge of human red cell pathophysiology Summary This review emphasises how studies on animal red cells have enriched our understanding of the behaviour of those from humans.
Kathleen M. Connolly, Pengyi Ding, Rasiqh Wadud, David C. Rees, John N. Brewin, John S. Gibson   +5 more
wiley   +1 more source

Synopsis of the 48th Annual Meeting of the Lake Cumberland Biological Transport Group and the Second Biannual Meeting of the Pendrin Consortium

Cellular Physiology and Biochemistry, 2013
Ion transporters are the molecular basis for ion homeostasis of the cell and the whole organism. The anion exchanger pendrin is only one of a number of examples where a complete or partial loss of function and/or deregulation of expression of ion ...
Silvia Dossena, Charity Nofziger, Rossana Morabito, Norma C. Adragna, Markus Paulmichl   +4 more
doaj   +1 more source

Absorptive transport of amino acids by the rat colon. [PDF]

, 2020
The capacity of the colon to absorb microbially produced amino acids (AAs) and the underlying mechanisms of AA transport are incompletely defined.
Chen, Yuxin, Cramer, Scott E, Dinges, Meredith M, Green, Andrew, Larive, Cynthia K, Lytle, Christian   +5 more
core  

Differential segment‐specific signalling pathways for guanylate cyclase C‐activated anion secretion in murine ileocolon

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Guanylate cyclase‐C (GC‐C) is the receptor for endogenous (uro)guanylin peptides, bacterial toxins and pharmacological analogues. Receptor activation leads to intestinal fluid loss, but also activates an antiproliferative pathway and is a promising target in colorectal cancer therapy.
Renjie Xiu, Johannes Reiner, Franz Hofmann, Azam Salari, Ursula Seidler   +4 more
wiley   +1 more source

Off-Label Use of Bumetanide for Brain Disorders: An Overview

Frontiers in Neuroscience, 2019
Bumetanide (BTN or BUM) is a FDA-approved potent loop diuretic (LD) that acts by antagonizing sodium-potassium-chloride (Na-K-Cl) cotransporters, NKCC1 (SLc12a2) and NKCC2.
Shivani C. Kharod, Seok Kyu Kang, Shilpa D. Kadam, Shilpa D. Kadam   +3 more
doaj   +1 more source

Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain [PDF]

, 2015
Peer ...
Jovanov-Milošević, Natasa, Judas, Milos, Kaila, Kai Kalervo, Krušlin, B, Puskarjov, Martin, Sedmak, Goran, Ulamec, Monica   +6 more
core   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, EarlyView.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

The Importance of Connexin 43 in Enamel Development and Mineralization

Frontiers in Physiology, 2018
During enamel development, formation of hydroxyapatite crystals and regulation of pH in the enamel matrix require massive transport of ions. Both ameloblasts and adjacent dental epithelial cells in the stellate reticulum co-express several transmembrane ...
Sali Al-Ansari, Rozita Jalali, Lilian I. Plotkin, Lilian I. Plotkin, Lilian I. Plotkin, Antonius L. J. J. Bronckers, Pamela DenBesten, Yan Zhang, Judith E. Raber-Durlacher, Judith E. Raber-Durlacher, Jan de Lange, Frederik R. Rozema, Frederik R. Rozema   +12 more
doaj   +1 more source