Results 171 to 180 of about 18,286 (218)
Mapping the multi-domain allosteric network for CKAMP44 modulation of AMPA receptors. [PDF]
J Biol ChemBharti P, Visal S, Vinnakota R, Kumar J.
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The effects of antidepressant drugs on kainate receptor mRNA levels
Neuropharmacology, 1991 We have measured the levels of kainate receptor mRNA in rat brains following the injection of antidepressant drugs over a time course up to 32 days. Over this period imipramine and fluvoxamine elicited a rise in kainate receptor mRNA levels to a maximum ...
P Buckland +2 more
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Nature, 1991 Kainic acid is a potent neurotoxin for certain neurons. Its neurotoxicity is thought to be mediated by an excitatory amino-acid-gated ion channel (ionotropic receptor) possessing nanomolar affinity for kainate.
Mark Voigt +2 more
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Cell and Tissue Research, 2006
Kainate receptors form a family of ionotropic glutamate receptors that appear to play a special role in the regulation of the activity of synaptic networks. This review first describes briefly the molecular and pharmacological properties of native and recombinant kainate receptors.
Paulo, Pinheiro, Christophe, Mulle
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Kainate receptors form a family of ionotropic glutamate receptors that appear to play a special role in the regulation of the activity of synaptic networks. This review first describes briefly the molecular and pharmacological properties of native and recombinant kainate receptors.
Paulo, Pinheiro, Christophe, Mulle
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Current Opinion in Neurobiology, 2000
Kainate receptors are a family of ionotropic glutamate receptors with poorly understood functions. Recent evidence firmly establishes kainate receptors as postsynaptic mediators of synaptic transmission. A second, presynaptic, modulatory role of kainate receptors has also been suggested, although the mechanism(s) involved remain controversial.
M, Frerking, R A, Nicoll
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Kainate receptors are a family of ionotropic glutamate receptors with poorly understood functions. Recent evidence firmly establishes kainate receptors as postsynaptic mediators of synaptic transmission. A second, presynaptic, modulatory role of kainate receptors has also been suggested, although the mechanism(s) involved remain controversial.
M, Frerking, R A, Nicoll
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Kainate receptors in the hippocampus
European Journal of Neuroscience, 2014AbstractKainate receptors (KARs) consist of a family of ionotropic glutamate receptors composed of the combinations of five subunits, GluK1–GluK5. Although KARs display close structural homology with AMPA receptors, they serve quite distinct functions.
Mario, Carta +3 more
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2010
Glutamate is the major fast excitatory amino acid transmitter in the CNS, and exerts its action through receptors that function as ion channels such as NMDA receptors (NMDARs), AMPA receptors (AMPARs), and kainate receptors (KARs), and also through signaling cascades via metabotropic receptors.
Erik B, Bloss, Richard G, Hunter
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Glutamate is the major fast excitatory amino acid transmitter in the CNS, and exerts its action through receptors that function as ion channels such as NMDA receptors (NMDARs), AMPA receptors (AMPARs), and kainate receptors (KARs), and also through signaling cascades via metabotropic receptors.
Erik B, Bloss, Richard G, Hunter
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Physiopathology of kainate receptors in epilepsy
Current Opinion in Pharmacology, 2015Kainate receptors (KARs) are tetrameric ionotropic glutamate receptors composed of the combinations of five subunits GluK1-GluK5. KARs are structurally related to AMPA receptors but they serve quite distinct functions by regulating the activity of synaptic circuits at presynaptic and postsynaptic sites, through either ionotropic or metabotropic actions.
Valérie, Crépel, Christophe, Mulle
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The Neuroscientist, 2013
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra +2 more
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Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra +2 more
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The synaptic activation of kainate receptors
Nature, 1997L-Glutamate, the principal excitatory neurotransmitter in the vertebrate central nervous system, acts on three classes of ionotropic glutamate receptors, named after the agonists AMPA, NMDA and kainate. AMPA receptors are known to mediate fast synaptic responses and NMDA receptors to mediate slow synaptic responses at most excitatory synapses in the ...
Vignes, M., Collingridge, G. L.
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