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Kainate receptors and synaptic plasticity
Nature, 2000Bortolotto et al.1 report that the kainate subtype of glutamate receptor is essential for the plasticity of certain types of synaptic transmission in the brain, which is of interest as these receptors were previously not thought to initiate plastic processes. In particular, a new antagonist (LY382884) was shown to act selectively against the GluR5 type
R A, Nicoll +3 more
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Synaptic plasticity of kainate receptors
Biochemical Society Transactions, 2006Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors.
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Inhibitors of AMPA and Kainate Receptors
Current Medicinal Chemistry, 2001The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen +2 more
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Kainate Receptors and Mossy Fiber LTP
NeuroToxicology, 2005There is considerable interest in understanding long-term potentiation (LTP) of glutamatergic synaptic transmission because the molecular mechanisms involved in its induction and expression are believed to be critical for learning and memory. There are two distinct forms of LTP.
Bortolotto, Za +4 more
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Kainate receptors and synaptic transmission
Progress in Neurobiology, 2003Excitatory glutamatergic transmission involves a variety of different receptor types, each with distinct properties and functions. Physiological studies have identified both post- and presynaptic roles for kainate receptors, which are a subtype of the ionotropic glutamate receptors.
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Kainate receptor pharmacology and physiology
Cellular and Molecular Life Sciences (CMLS), 1999Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists.
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Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
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