Results 161 to 170 of about 1,356,843 (204)
Some of the next articles are maybe not open access.
Neuropharmacology of AMPA and Kainate Receptors
Neuropharmacology, 1998David Lodge, David Bleakman, D Bleakman
exaly +3 more sources
Current Opinion in Neurobiology, 2000
Kainate receptors are a family of ionotropic glutamate receptors with poorly understood functions. Recent evidence firmly establishes kainate receptors as postsynaptic mediators of synaptic transmission. A second, presynaptic, modulatory role of kainate receptors has also been suggested, although the mechanism(s) involved remain controversial.
M, Frerking, R A, Nicoll
openaire +2 more sources
Kainate receptors are a family of ionotropic glutamate receptors with poorly understood functions. Recent evidence firmly establishes kainate receptors as postsynaptic mediators of synaptic transmission. A second, presynaptic, modulatory role of kainate receptors has also been suggested, although the mechanism(s) involved remain controversial.
M, Frerking, R A, Nicoll
openaire +2 more sources
Kainate receptors in the hippocampus
European Journal of Neuroscience, 2014AbstractKainate receptors (KARs) consist of a family of ionotropic glutamate receptors composed of the combinations of five subunits, GluK1–GluK5. Although KARs display close structural homology with AMPA receptors, they serve quite distinct functions.
Carta, Mario +3 more
openaire +2 more sources
2010
Glutamate is the major fast excitatory amino acid transmitter in the CNS, and exerts its action through receptors that function as ion channels such as NMDA receptors (NMDARs), AMPA receptors (AMPARs), and kainate receptors (KARs), and also through signaling cascades via metabotropic receptors.
Erik B, Bloss, Richard G, Hunter
openaire +2 more sources
Glutamate is the major fast excitatory amino acid transmitter in the CNS, and exerts its action through receptors that function as ion channels such as NMDA receptors (NMDARs), AMPA receptors (AMPARs), and kainate receptors (KARs), and also through signaling cascades via metabotropic receptors.
Erik B, Bloss, Richard G, Hunter
openaire +2 more sources
Physiopathology of kainate receptors in epilepsy
Current Opinion in Pharmacology, 2015Kainate receptors (KARs) are tetrameric ionotropic glutamate receptors composed of the combinations of five subunits GluK1-GluK5. KARs are structurally related to AMPA receptors but they serve quite distinct functions by regulating the activity of synaptic circuits at presynaptic and postsynaptic sites, through either ionotropic or metabotropic actions.
Valérie, Crépel, Christophe, Mulle
openaire +2 more sources
Desensitization of Kainate Receptors by Kainate, Glutamate and Diastereomers of 4-Methylglutamate
Neuropharmacology, 1997The potencies of kainate, glutamate and diastereomers of 4-methylglutamate were determined for activation and steady-state desensitization of GluR6 and dorsal root ganglion-type kainate receptors using whole-cell voltage clamp. In HEK293 cells expressing GluR6, all four diastereomers induced desensitizing inward currents at relatively high ...
K A Jones
exaly +3 more sources
The Neuroscientist, 2013
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra +2 more
openaire +2 more sources
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra +2 more
openaire +2 more sources
Role of kainate receptors in nociception
Brain Research Reviews, 2002Nociceptive nerve fibers use L-glutamate as a fast excitatory neurotransmitter and it is therefore not surprising that both, ionotropic and metabotropic glutamate receptors play pivotal roles for transmission of nociceptive information in spinal cord.
Ruth, Ruscheweyh, Jürgen, Sandkühler
openaire +2 more sources
Structural biology of kainate receptors
Neuropharmacology, 2021This review summarizes structural studies on kainate receptors that explain unique functional properties of this receptor family. A large number of structures have been solved for ligand binding domain dimer assemblies, giving insight into the subtype selective pharmacology of agonists, antagonists, and allosteric modulators. Structures and biochemical
openaire +2 more sources
Kainate receptors in epilepsy and excitotoxicity
Neuroscience, 2009Kainate (KA), an analog of glutamate, is a potent neurotoxin that has long been known to induce behavioral and electrophysiological seizures as well as neuropathological lesions reminiscent of those found in patients with temporal lobe epilepsy. More than a decade after the initial KA studies, molecular cloning of ionotropic glutamate receptors ...
P, Vincent, C, Mulle
openaire +2 more sources