Results 141 to 150 of about 15,689 (185)

Kainate Receptors

The Neuroscientist, 2013
Ionotropic glutamate receptors of the N-methyl-d-aspartate (NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have been extensively invoked in plasticity. Until relatively recently, however, kainate-type receptors (KARs) had been the most elusive to study because of the lack of appropriate pharmacological tools to specifically address ...
Talvinder S, Sihra, Gonzalo, Flores, Antonio, Rodríguez-Moreno   +2 more
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The synaptic activation of kainate receptors

Nature, 1997
L-Glutamate, the principal excitatory neurotransmitter in the vertebrate central nervous system, acts on three classes of ionotropic glutamate receptors, named after the agonists AMPA, NMDA and kainate. AMPA receptors are known to mediate fast synaptic responses and NMDA receptors to mediate slow synaptic responses at most excitatory synapses in the ...
Vignes, M., Collingridge, G. L.
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Role of kainate receptors in nociception

Brain Research Reviews, 2002
Nociceptive nerve fibers use L-glutamate as a fast excitatory neurotransmitter and it is therefore not surprising that both, ionotropic and metabotropic glutamate receptors play pivotal roles for transmission of nociceptive information in spinal cord.
Ruth, Ruscheweyh, Jürgen, Sandkühler
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Structural biology of kainate receptors

Neuropharmacology, 2021
This review summarizes structural studies on kainate receptors that explain unique functional properties of this receptor family. A large number of structures have been solved for ligand binding domain dimer assemblies, giving insight into the subtype selective pharmacology of agonists, antagonists, and allosteric modulators. Structures and biochemical
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Kainate receptors in epilepsy and excitotoxicity

Neuroscience, 2009
Kainate (KA), an analog of glutamate, is a potent neurotoxin that has long been known to induce behavioral and electrophysiological seizures as well as neuropathological lesions reminiscent of those found in patients with temporal lobe epilepsy. More than a decade after the initial KA studies, molecular cloning of ionotropic glutamate receptors ...
P, Vincent, C, Mulle
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Kainate receptors and synaptic plasticity

Nature, 2000
Bortolotto et al.1 report that the kainate subtype of glutamate receptor is essential for the plasticity of certain types of synaptic transmission in the brain, which is of interest as these receptors were previously not thought to initiate plastic processes. In particular, a new antagonist (LY382884) was shown to act selectively against the GluR5 type
R A, Nicoll, J, Mellor, M, Frerking, D, Schmitz   +3 more
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Synaptic plasticity of kainate receptors

Biochemical Society Transactions, 2006
Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors.
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Inhibitors of AMPA and Kainate Receptors

Current Medicinal Chemistry, 2001
The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen, T B, Stensbøl, P, Krogsgaard-Larsen   +2 more
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Kainate Receptors and Mossy Fiber LTP

NeuroToxicology, 2005
There is considerable interest in understanding long-term potentiation (LTP) of glutamatergic synaptic transmission because the molecular mechanisms involved in its induction and expression are believed to be critical for learning and memory. There are two distinct forms of LTP.
Bortolotto, Za, NISTICO', ROBERT GIOVANNI, More, JC, Jane, DE, Collingridge, GL   +4 more
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Desensitization of Kainate Receptors by Kainate, Glutamate and Diastereomers of 4-Methylglutamate

Neuropharmacology, 1997
The potencies of kainate, glutamate and diastereomers of 4-methylglutamate were determined for activation and steady-state desensitization of GluR6 and dorsal root ganglion-type kainate receptors using whole-cell voltage clamp. In HEK293 cells expressing GluR6, all four diastereomers induced desensitizing inward currents at relatively high ...
K A, Jones, T J, Wilding, J E, Huettner, A M, Costa   +3 more
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