Results 121 to 130 of about 18,286 (218)

On the Modelling of Kainate Receptor Channels

, 2014
Kainate receptor channels are a class of ion channels found on the membrane of nerve cells. These proteins play a key role in the brain, since their properties regulate the strength of the synapses.
Nabil, Tahar Etienne
core  

Generation and Analysis of GluR5(Q636R) Kainate Receptor Mutant Mice

, 1999
The physiological significance of RNA editing of transcripts that code for kainate-preferring glutamate receptor subunits is unknown, despite the fact that the functional consequences of this molecular modification have been well characterized in cloned ...
Tony L. Yaksh, Lora O’Leary, Hans H. Schiffer, Geoffrey T. Swanson, Heather Dickinson-Anson, Stephen O’Gorman, Isabel Pérez-Otaño, Fred H. Gage, Cornelia Maron, Richard H. Dyck, Andreas Sailer, Shelle A. Malkmus, Stephen F. Heinemann   +12 more
core   +1 more source

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype. [PDF]

Int J Mol Sci, 2022
Chałupnik P, Vialko A, Pickering DS, Hinkkanen M, Donbosco S, Møller TC, Jensen AA, Nielsen B, Bay Y, Kristensen AS, Johansen TN, Łątka K, Bajda M, Szymańska E.   +13 more
europepmc   +1 more source

The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus

, 1996
International audienceTwo new compounds (LY293558 and LY294486), that antagonize homomeric human GluR5 receptors, were examined against responses mediated by kainate receptors in the CA3 region of rat hippocampal slices.
Collingridge, G. L., Lodge, D., D. Lodge, D. Bleakman, G.L. Collingridge, Vignes, M., M. Vignes, Bleakman, D.   +7 more
core   +1 more source

Topiramate and other kainate receptor antagonists for depression: A systematic review of randomized controlled trials. [PDF]

Neuropsychopharmacol Rep, 2022
Shamabadi A.
europepmc   +1 more source

Regulation of metabotropic glutamate receptor subtype 7a by PDZ-domain protein PICK1

, 2007
Metabotropic glutamate receptor subtype 7 (mGluR7) belongs to the family of G-protein coupled receptors. mGluR7 is widely distributed in the brain and primarily localized at presynaptic terminals, where it is thought to regulate neurotransmitter release ...
Zhang, C., Zhang, Chuansheng
core  

Quantitative localization of AMPA/kainate and kainate glutamate receptor subunit immunoreactivity in neurochemically identified subpopulations of neurons in the prefrontal cortex of the macaque monkey

, 1993
Excitatory amino acid transmission has been proposed as the principal synaptic mechanism for distribution of information through corticocortical and thalamocortical pathways.
SF Heinemann, JH Morrison, T Moran, JC Vickers, AM Edwards, GW Huntley, SW Rogers   +6 more
core   +1 more source

Neuroprotection induced by protease-activated receptor 2 activation is independent of Gq signalling

Brain and Neuroscience Advances
Protease-activated receptor 2 is proposed to be a novel target for several inflammation-related diseases but its role in the central nervous system remains unclear.
Serge Moudio, Hugh N. Nuthall, Trevor J. Bushell   +2 more
doaj   +1 more source

Structural and compositional diversity in the kainate receptor family. [PDF]

Cell Rep, 2021
Selvakumar P, Lee J, Khanra N, He C, Munguba H, Kiese L, Broichhagen J, Reiner A, Levitz J, Meyerson JR.   +9 more
europepmc   +1 more source

Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.

, 2002
International audienceThe relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs) that ...
Crépel, Valérie, Hirsch, June, Tyzio, Roman, Cossart, Rosa, Epsztein, Jérôme, Hirsch, June, C., Becq, Hélène, Ben-Ari, Yehezkel   +7 more
core   +1 more source