Results 101 to 110 of about 1,356,843 (204)

Glutamate Receptors in Nucleus Accumbens Can Modulate Canabinoid-Induced Antinociception in Rat’s Basolateral Amygdala

Basic and Clinical Neuroscience, 2012
Introduction: It has been shown that administration of WIN55,212-2, a cannabinoid receptor agonist, into the basolateral amygdala (BLA), dose-dependently increases the thermal latency to withdrawal in the tail-.ick test and decreases pain related ...
Mohadeseh Ghalandari-Shamami, Majid Hassanpour-Ezatti, Abbas Haghparast   +2 more
doaj  

On the Modelling of Kainate Receptor Channels

, 2014
Kainate receptor channels are a class of ion channels found on the membrane of nerve cells. These proteins play a key role in the brain, since their properties regulate the strength of the synapses.
Nabil, Tahar Etienne
core   +2 more sources

Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice

, 2014
Kainate-induced seizures constitute a model of temporal lobe epilepsy where prominent changes are observed in the hippocampal neuropeptide Y (NPY) system.
Waterfield, Allison, Elbrønd-Bek, Heidi, Gøtzsche, Casper René, Woldbye, David Paul Drucker, Olling, Janne Damm, Wörtwein, Gitta   +5 more
core   +1 more source

Distribution of Kainate Receptor Subunits at Hippocampal Mossy Fiber Synapses

, 2003
Kainate receptors function as mediators of postsynaptic currents and as presynaptic modulators of synaptic transmission at mossy fiber synapses. Despite intense research into the physiological properties of mossy fiber kainate receptors, their subunit ...
Robert J. Wenthold, Petralia, Ronald S., Ronald S. Petralia, Swanson, Geoffrey T., Melanie Darstein, Darstein, Melanie, Geoffrey T. Swanson, Heinemann, Stephen F., Stephen F. Heinemann, Wenthold, Robert J.   +9 more
core   +1 more source

Kainate Receptor Antagonists: Recent Advances and Therapeutic Perspective. [PDF]

Int J Mol Sci, 2023
Chałupnik P, Szymańska E.
europepmc   +1 more source

Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. [PDF]

Am J Hum Genet, 2021
Stolz JR, Foote KM, Veenstra-Knol HE, Pfundt R, Ten Broeke SW, de Leeuw N, Roht L, Pajusalu S, Part R, Rebane I, Õunap K, Stark Z, Kirk EP, Lawson JA, Lunke S, Christodoulou J, Louie RJ, Rogers RC, Davis JM, Innes AM, Wei XC, Keren B, Mignot C, Lebel RR, Sperber SM, Sakonju A, Dosa N, Barge-Schaapveld DQCM, Peeters-Scholte CMPCD, Ruivenkamp CAL, van Bon BW, Kennedy J, Low KJ, Ellard S, Pang L, Junewick JJ, Mark PR, Carvill GL, Swanson GT.   +38 more
europepmc   +2 more sources

Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor

, 2004
Upon agonist binding, the bilobate ligand-binding domains of the ionotropic glutamate receptors (iGluR) undergo a cleft closure whose magnitude correlates broadly with the efficacy of the agonist. AMPA (-amino-5-methyl-3-hydroxy-4-isoxazolepropionic acid)
Reinelt, S., Cheng, Q., Thiran, S., Keinänen, K., Zimmermann, H., Rajan, S., Jayaraman, V., Rigo, F., Madden, D.   +8 more
core   +1 more source

Neuroprotection induced by protease-activated receptor 2 activation is independent of Gq signalling

Brain and Neuroscience Advances
Protease-activated receptor 2 is proposed to be a novel target for several inflammation-related diseases but its role in the central nervous system remains unclear.
Serge Moudio, Hugh N. Nuthall, Trevor J. Bushell   +2 more
doaj   +1 more source

Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor Subtype. [PDF]

Int J Mol Sci, 2022
Chałupnik P, Vialko A, Pickering DS, Hinkkanen M, Donbosco S, Møller TC, Jensen AA, Nielsen B, Bay Y, Kristensen AS, Johansen TN, Łątka K, Bajda M, Szymańska E.   +13 more
europepmc   +1 more source

3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands

, 2009
Udgivelsesdato: 2009-Sep-1On the basis of X-ray structures of ionotropic glutamate receptor constructs in complex with amino acid-based AMPA and kainate receptor antagonists, a series of rigid as well as flexible biaromatic alanine derivatives carrying ...
Pickering, Darryl S, Szymanska, Ewa, Johansen, Tommy N, Nielsen, Birgitte, Ewa Szymańska, Darryl S. Pickering, Birgitte Nielsen, Tommy N. Johansen   +7 more
core   +1 more source