Results 91 to 100 of about 18,286 (218)

Decrease in tobacco consumption after treatment with topiramate and aripiprazole: a case report

Journal of Medical Case Reports, 2008
Introduction A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the ...
Arbaizar Beatriz, Gómez-Acebo Inés, Llorca Javier   +2 more
doaj   +1 more source

GluK2-mediated excitability within the superficial layers of the entorhinal cortex.

PLoS ONE, 2009
Recent analysis of genetically modified mice deficient in different kainate receptor (KAR) subunits have strongly pointed to a role of the GluK2 subunit, mediating the vulnerability of the brain towards seizures.
Prateep S Beed, Benedikt Salmen, Dietmar Schmitz   +2 more
doaj   +1 more source

Selective antagonism of AMPA receptors unmasks kainate receptor-mediated responses in hippocampal neurons

, 1995
5 páginas, 3 figuras.Although both protein and mRNAs for kainate receptor subunits are abundant in several brain regions, the responsiveness of AMPA receptors to kainate has made it difficult to demonstrate the presence of functional kainate-type ...
Morales, Miguel, Paternain, Ana V., Miguel Morales, Lerma Gómez, Juan, Ana V Paternain, Lerma, Juan, Paternain, Ana V, Juan Lerma   +7 more
core   +1 more source

Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures

Neurobiology of Disease, 2015
The aim of this study was to investigate the role of the synaptic metabotropic zinc receptor mZnR/GPR39 in physiological adaptation to epileptic seizures.
David Gilad, Sharon Shorer, Maya Ketzef, Alon Friedman, Israel Sekler, Elias Aizenman, Michal Hershfinkel   +6 more
doaj   +1 more source

Ionotropic receptors at hippocampal mossy fibres: roles in axonal excitability, synaptic transmission and plasticity

Frontiers in Neural Circuits, 2013
Dentate granule cells process information from the enthorinal cortex en route to the hippocampus proper. These neurons have a very negative resting membrane potential and are relatively silent in the slice preparation.
Arnaud J Ruiz, Dimitri M Kullmann
doaj   +1 more source

Structure and gating of kainate receptors

Frontiers in Pharmacology
Ionotropic glutamate receptors (iGluRs) are crucial for fast excitatory neurotransmission in the mammalian central nervous system (CNS). Kainate receptors (KARs), a subclass of iGluRs, are tetrameric, ligand-gated ion channels that play key modulatory roles at both pre- and post-synaptic sites within neuronal circuits and in the regulation of synaptic ...
Gangwar, Shanti P., Yelshanskaya, Maria V., Yen, Laura Y., Newton, Thomas P., Sobolevsky, Alexander I.   +4 more
openaire   +3 more sources

Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression [PDF]

Front Mol Neurosci, 2023
Yucel BP, Al Momany EM, Evans AJ, Seager R, Wilkinson KA, Henley JM.   +5 more
europepmc   +2 more sources

Antagonism of ionotropic glutamate receptors attenuates chemical ischemia-induced injury in rat primary cultured myenteric ganglia.

PLoS ONE, 2014
Alterations of the enteric glutamatergic transmission may underlay changes in the function of myenteric neurons following intestinal ischemia and reperfusion (I/R) contributing to impairment of gastrointestinal motility occurring in these pathological ...
Elisa Carpanese, Paola Moretto, Viviana Filpa, Silvia Marchet, Elisabetta Moro, Francesca Crema, Gianmario Frigo, Cristina Giaroni   +7 more
doaj   +1 more source

Cortical neurones exhibiting kainate-activated Co2+uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

Neurobiology of Disease, 1994
Kainate-activated Co2+uptake, a histochemical method that identifies cells bearing Ca2+-permeable AMPA/kainate receptors, labels approximately 15% of murine cortical neurones in cell culture.
Dorothy M. Turetsky, Lorella M.T. Canzoniero, Stefano L. Sensi, John H. Weiss, Mark P. Goldberg, Dennis W. Choi   +5 more
doaj   +1 more source

Distribution of Kainate Receptor Subunits at Hippocampal Mossy Fiber Synapses

, 2003
Kainate receptors function as mediators of postsynaptic currents and as presynaptic modulators of synaptic transmission at mossy fiber synapses. Despite intense research into the physiological properties of mossy fiber kainate receptors, their subunit ...
Robert J. Wenthold, Petralia, Ronald S., Ronald S. Petralia, Swanson, Geoffrey T., Melanie Darstein, Darstein, Melanie, Geoffrey T. Swanson, Heinemann, Stephen F., Stephen F. Heinemann, Wenthold, Robert J.   +9 more
core   +1 more source