Results 91 to 100 of about 1,356,843 (204)

Synthesis of a Series of Aryl Kainic Acid Analogs and Evaluation in Cells Stably Expressing the Kainate Receptor humGluR6

, 2016
The synthesis and pharmacological characterization of a novel series of 4-aryl-substituted kainic acid analogs are described. Receptor affinities were determined on recombinantly expressed humGluR6 kainate receptors and on [3H]kainate binding to rat ...
Buddy E. Cantrell (2725051), David Bleakman (2497171), Dennis M. Zimmerman (2725048), Louise N. Farrell (3018546), James A. Monn (1947361), Joseph P. Tizzano (2674249), Ken H. Hoo (3018543), Ian A. Pullar (3018549), Rajender K. Kamboj (3013455)   +8 more
core   +1 more source

Antagonism of ionotropic glutamate receptors attenuates chemical ischemia-induced injury in rat primary cultured myenteric ganglia.

PLoS ONE, 2014
Alterations of the enteric glutamatergic transmission may underlay changes in the function of myenteric neurons following intestinal ischemia and reperfusion (I/R) contributing to impairment of gastrointestinal motility occurring in these pathological ...
Elisa Carpanese, Paola Moretto, Viviana Filpa, Silvia Marchet, Elisabetta Moro, Francesca Crema, Gianmario Frigo, Cristina Giaroni   +7 more
doaj   +1 more source

Cortical neurones exhibiting kainate-activated Co2+uptake are selectively vulnerable to AMPA/kainate receptor-mediated toxicity

Neurobiology of Disease, 1994
Kainate-activated Co2+uptake, a histochemical method that identifies cells bearing Ca2+-permeable AMPA/kainate receptors, labels approximately 15% of murine cortical neurones in cell culture.
Dorothy M. Turetsky, Lorella M.T. Canzoniero, Stefano L. Sensi, John H. Weiss, Mark P. Goldberg, Dennis W. Choi   +5 more
doaj   +1 more source

Effects of chronic haloperidol and clozapine treatment on AMPA and kainate receptor binding in rat brain

, 2003
BACKGROUND: Alterations in AMPA and kainate receptor binding have been revealed in post-mortem schizophrenic brains. As most patients had been treated with antipsychotics, medication effects cannot be excluded as a possible explanation for these results.
Muller, B., Braus, D. F., Jatzko, A., Petroianu, G., Schmitt, A., Henn, F. A., May, B.   +6 more
core   +1 more source

Functional implications of the exon 9 splice insert in GluK1 kainate receptors

eLife
Kainate receptors are key modulators of synaptic transmission and plasticity in the central nervous system. Different kainate receptor isoforms with distinct spatiotemporal expressions have been identified in the brain.
Surbhi Dhingra, Prachi M Chopade, Rajesh Vinnakota, Janesh Kumar   +3 more
doaj   +1 more source

The synaptic activation of the GluR5 subtype of kainate receptor in area CA3 of the rat hippocampus

, 1996
International audienceTwo new compounds (LY293558 and LY294486), that antagonize homomeric human GluR5 receptors, were examined against responses mediated by kainate receptors in the CA3 region of rat hippocampal slices.
Collingridge, G. L., Lodge, D., D. Lodge, D. Bleakman, G.L. Collingridge, Vignes, M., M. Vignes, Bleakman, D.   +7 more
core   +1 more source

Differential suppression of seizures via Y2 and Y5 neuropeptide Y receptors

Neurobiology of Disease, 2005
Neuropeptide Y (NPY) prominently inhibits epileptic seizures in different animal models. The NPY receptors mediating this effect remain controversial partially due to lack of highly selective agonists and antagonists.
David P.D. Woldbye, Avtandil Nanobashvili, Andreas T. Sørensen, Henriette Husum, Tom G. Bolwig, Gunnar Sørensen, Patrik Ernfors, Merab Kokaia   +7 more
doaj   +1 more source

Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA

, 1991
Fast excitatory transmission in the vertebrate central nervous system is mediated mainly by L-glutamate. On the basis of pharmacological, physiological and agonist binding properties, the ionotropic glutamate receptors are classified into NMDA (N-methyl ...
Bernhard Bettler, Hermans-Borgmeyer, I., Heinemann, S., Stephen Heinemann, Bettler, B., Jan Egebjerg, Egebjerg, J., Irm Hermans-Borgmeyer   +7 more
core   +1 more source

Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface expression [PDF]

Front Mol Neurosci, 2023
Yucel BP, Al Momany EM, Evans AJ, Seager R, Wilkinson KA, Henley JM.   +5 more
europepmc   +2 more sources

Kainate Receptor-mediated Regulation of Chloride Homeostasis [PDF]

, 2019
A balance between excitatory and inhibitory activity is needed to maintain proper brain function. At inhibitory synapses, potassium-chloride cotransporter 2 (KCC2) has long been known to be a critical regulator of inhibition through its ability to ...
Garand, Danielle
core   +1 more source