Results 71 to 80 of about 18,286 (218)
Ampa and kainate receptor-potentiating RNA aptamers
, 2021 Glutamate receptors act to bring about excitatory transmission in the central nervous system. The receptors are divided into two groups: ionotropic and metabotropic glutamate receptors. Ionotropic glutamate receptors are ion channels which are activated
Lynch, Janet L
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Therapeutic Potential of Kainate Receptors [PDF]
CNS Neuroscience & Therapeutics, 2010 SUMMARYGlutamate receptors are key mediators of brain communication. Among ionotropic glutamate receptors, kainate receptors (KARs) have been least explored and their relevance to pathophysiology is relatively obscure. This is in part due to the relatively low abundance of KARs, the regulatory function in network activity they play, the lack of ...
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Kainate receptor trafficking [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011 AbstractKainate receptors (KARs) are ligand‐gated ion channels that can regulate neuronal network activity and are involved in processes ranging from neuronal development and differentiation to neurodegeneration and neuronal cell death. They are tetrameric assemblies which can comprise different subunit combinations and are differentially targeted to ...
Inmaculada M. González‐González +6 more
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Neurobiology of Disease, 2004 The cause of the selective degeneration of motor neurons in amyotrophic lateral sclerosis (ALS) remains a mystery. One potential pathogenic mechanism is excitotoxicity due to disturbances of glutamatergic neurotransmission, particularly via AMPA ...
Alida Spalloni +6 more
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Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures
Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.This study demonstrated that sleep deprivation induces transcriptomic changes in mice and rats similar to those observed in various models of neuronal hyperexcitation. These findings suggest a potential link between sleep deprivation and neuropsychiatric disorders.
Markos Michail Chatzigiannis +2 more
wiley +1 more source
Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex
Cell Reports, 2012 Ionotropic glutamate receptors assemble as homo- or heterotetramers. One well-studied heteromeric complex is formed by the kainate receptor subunits GluK2 and GluK5.
Andreas Reiner +2 more
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The Role of Meprins on the Brain Extracellular Matrix and Perineuronal Nets
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Meprin β overexpression is implicated in Alzheimer's Disease. Recent studies identified brevican as a meprin β substrate, and this study demonstrates that meprin α co‐expression enhances meprin β‐mediated brevican cleavage. Further, neurocan and RPTPζ were identified as novel meprin β substrates in an N‐terminomics analysis of meprin β transgenic mice,
Simon Kreiselmaier +13 more
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3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands
, 2009 Udgivelsesdato: 2009-Sep-1On the basis of X-ray structures of ionotropic glutamate receptor constructs in complex with amino acid-based AMPA and kainate receptor antagonists, a series of rigid as well as flexible biaromatic alanine derivatives carrying ...
Pickering, Darryl S +3 more
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Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management
MedComm, Volume 7, Issue 7, July 2026.Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu +8 more
wiley +1 more source
Kainate receptor function in rodent subcortical visual processing.
, 2007 Glutamate is found throughout the central nervous system and has been shown to be an important excitatory neurotransmitter in the visual system. There are two subdivisions of receptor on which this ubiquitous neurotransmitter acts, metabotropic (mGluR ...
Pothecary, C.A.
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