Results 51 to 60 of about 1,356,843 (204)
The translational asymmetry of corpus callosotomy: Two literatures that answered different questions
Epilepsia Open, EarlyView.Abstract Corpus callosotomy is an established palliative operation for drug‐resistant epilepsy dominated by drop attacks, and it is performed in three extents: anterior, usually of the anterior two‐thirds; total, in one or two stages; and selective posterior, which preserves the genu and rostral body.
Vitória Bernal Cavalcanti +1 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose Gamma‐glutamyl dipeptides are essentially produced after glutathione (GSH) degradation. While several γ‐glutamyl dipeptides have been detected in different organs and body fluids, their biological activity remains elusive. This is the case for γ‐Glutamyl‐Glycine (γ‐Glu‐Gly) which has been found in different brain areas.
Sandro Andreu +20 more
wiley +1 more source
Neurobiology of Disease, 2016 Although novel treatment strategies based on the gene therapy approach for epilepsy has been encouraging, there is still a gap in demonstrating a proof-of-concept in a clinically relevant animal model and study design.
Litsa Nikitidou Ledri +6 more
doaj +1 more source
Kainate Receptor-Mediated Responses in the CA1 Field of Wild-Type and GluR6-Deficient Mice
, 1999 Kainate receptors are abundantly expressed in the hippocampus. Mice with disruption of kainate receptor subunits allow the genetic dissection of the role of each kainate receptor subunits in the synaptic physiology of the hippocampus, as well as in ...
Ingrid Bureau +3 more
core +1 more source
The FEBS Journal, EarlyView.Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester +11 more
wiley +1 more source
Kainate receptors: on the dark side [PDF]
The Journal of Physiology, 2014 Synaptic glutamate receptors can be divided into metabotropic receptors, an eight-member GPCR family, and ionotropic glutamate receptors, a three-member family of NMDA, kainate, and AMPA tetrameric receptors. The most neglected are the five subunit (GluK1–5) kainate receptors, often either lumped with the AMPA receptors because of pharmacological ...
openaire +2 more sources
PLoS ONE, 2017 Kainate receptors mediate glutamatergic signaling through both pre- and presynaptic receptors. Here, we studied the expression of the high affinity kainate receptor GluK5 in the mouse retina.
Iris Haumann +3 more
doaj +1 more source
Crucial Roles of the Endocannabinoid 2-Arachidonoylglycerol in the Suppression of Epileptic Seizures
Cell Reports, 2016 Endocannabinoid signaling is considered to suppress excessive excitability of neural circuits and to protect the brain from seizures. However, the precise mechanisms of this effect are poorly understood. Here, we report that 2-arachidonoylglycerol (2-AG),
Yuki Sugaya +6 more
doaj +1 more source
The FEBS Journal, EarlyView.GluD1 belongs to the ionotropic glutamate receptors and has important functions in the brain and brain diseases. We report the crystal structure of the GluD1 ligand‐binding domain with D‐serine and zinc ions. MD simulations supported promiscuous binding of cations and that chloride ions play a stabilizing role. Pro725 seems to hinder interlobe closure,
Flemming Steen Jørgensen +4 more
wiley +1 more source
Molecular Physiology of Kainate Receptors [PDF]
Physiological Reviews, 2001 A decade ago, our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology was essentially null. A plethora of recent studies has altered this situation profoundly such that kainate receptors are now regarded as key players in the modulation of transmitter release, as important mediators of the ...
Lerma Gómez, Juan +3 more
openaire +3 more sources