Results 41 to 50 of about 1,356,843 (204)
Epilepsia Open, EarlyView.Abstract The intestinal microbiome plays a pivotal role in maintaining host health through its involvement in gastrointestinal, immune, and central nervous system (CNS) functions. Recent evidence underscores the bidirectional communication between the microbiota, the gut, and the brain and the impact of this axis on neurological diseases, including ...
Teresa Ravizza +4 more
wiley +1 more source
Kainate Receptors: Role in Epilepsy [PDF]
Frontiers in Molecular Neuroscience, 2018 Kainate (KA) is a potent neurotoxin that has been widely used experimentally to induce acute brain seizures and, after repetitive treatments, as a chronic model of temporal lobe epilepsy (TLE), with similar features to those observed in human patients with TLE.
Falcon-Moya, R +2 more
openaire +4 more sources
Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus.
PLoS ONE, 2009 Kainate receptors are a class of ionotropic glutamate receptors that have a role in the modulation of glutamate release and synaptic plasticity in the hippocampal formation.
Richard G Hunter +5 more
doaj +1 more source
Synthesis and Pharmacology of a New AMPA−Kainate Receptor Agonist with Potent Convulsant Activity
, 2016 Synthesis and Pharmacology of a New AMPA−Kainate Receptor Agonist with Potent Convulsant ...
Giovambattista De Sarro (2013070) +6 more
core +1 more source
, 2023 Spectroscopy data for chemical compounds described in the paper "Discovery of the First Highly Selective Antagonist of the GluK3 Kainate Receptor ...
Szymańska, Ewa, Chałupnik, Paulina
core +1 more source
The multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou +6 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2011 Diazepam (DZP) and phenobarbital (PB) are extensively used as first and second line drugs to treat acute seizures in neonates and their actions are thought to be mediated by increasing the actions of GABAergic signals.
Romain eNardou +17 more
doaj +1 more source
, 1995 5 páginas, 3 figuras.Although both protein and mRNAs for kainate receptor subunits are abundant in several brain regions, the responsiveness of AMPA receptors to kainate has made it difficult to demonstrate the presence of functional kainate-type ...
Morales, Miguel +5 more
core +1 more source
Neonatal seizures and GABAergic drugs: Scylla and Charybdis?
Epilepsia Open, EarlyView.Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson +2 more
wiley +1 more source
Neurobiology of Disease, 2012 We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche +8 more
doaj +1 more source