Results 21 to 30 of about 1,356,843 (204)
Neurobiology of Disease, 1994 A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin +3 more
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Clathrin-independent but dynamin-dependent mechanisms mediate Ca2+-triggered endocytosis of the glutamate GluK2 receptor upon excitotoxicity [PDF]
Journal of Integrative Neuroscience, 2020 We first explore the features of GluK2 endocytosis during kainate excitotoxicity and then explore the role of Ca2+ in the regulation of GluK2 endocytosis. The roles of Ca2+ were examined by treating cells with Ca2+ inhibitors or chelators.
Jing-Jing Du, Lu Yan, Wei Zhang, Hao Xu, Qiu-Ju Zhu
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AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells
Frontiers in Cellular Neuroscience, 2019 Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
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Neurobiology of Disease, 2014 Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas +5 more
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Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains
eLife, 2017 Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly.
Huaying Zhao +5 more
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AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures
Neurobiology of Disease, 1999 Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez +1 more
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Kainate receptor modulation by NETO2
Nature, 2021 Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos).
Lingli He +12 more
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Mast Cells In Kainate Receptor Knockout Mice [PDF]
, 2015 Kainate receptor knockout mice have unique differences within their immune system. They exhibit an attenuated TH2 branch, while maintaining a robust TH1 response.
Elkovich, Andrea J
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Neurobiology of Disease, 2002 Oligodendrocytes are vulnerable to excitotoxic insults mediated by AMPA receptors and by low and high affinity kainate receptors, a feature that is dependent on Ca2+ influx.
Elena Alberdi +3 more
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Frontiers in Cellular Neuroscience, 2015 Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear ...
Jacqueline eGayet-Primo +1 more
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