Results 21 to 30 of about 15,689 (185)

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

Neurobiology of Disease, 2014
Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas, Paoula Gueorguieva, Nadia Lelutiu, Yi Quan, Renee Shaw, Raymond Dingledine   +5 more
doaj   +1 more source

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains

eLife, 2017
Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly.
Huaying Zhao, Suvendu Lomash, Sagar Chittori, Carla Glasser, Mark L Mayer, Peter Schuck   +5 more
doaj   +1 more source

Kainate receptor modulation by NETO2

Nature, 2021
Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos).
Lingli He, Jiahui Sun, Yiwei Gao, Bin Li, Yuhang Wang, Yanli Dong, Weidong An, Hang Li, Bei Yang, Yuhan Ge, Xuejun Cai Zhang, Yun Stone Shi, Yan Zhao   +12 more
openaire   +3 more sources

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

Neurobiology of Disease, 1999
Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez, Carlos Matute   +1 more
doaj   +1 more source

Ca2+ Influx through AMPA or Kainate Receptors Alone Is Sufficient to Initiate Excitotoxicity in Cultured Oligodendrocytes

Neurobiology of Disease, 2002
Oligodendrocytes are vulnerable to excitotoxic insults mediated by AMPA receptors and by low and high affinity kainate receptors, a feature that is dependent on Ca2+ influx.
Elena Alberdi, Marı́a Victoria Sánchez-Gómez, Aida Marino, Carlos Matute   +3 more
doaj   +1 more source

Alterations in kainate receptor and TRPM1 localization in bipolar cells after retinal photoreceptor degeneration

Frontiers in Cellular Neuroscience, 2015
Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear ...
Jacqueline eGayet-Primo, Theresa ePuthussery   +1 more
doaj   +1 more source

Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy

EBioMedicine, 2021
Background: In the setting of drug-resistant epilepsy (DRE), the success of surgery depends on the ability to accurately locate the epileptic foci to be resected or disconnected.
Cong Wang, Jianping Zhang, Shaoli Song, Zhi Li, Shujie Yin, Wenjia Duan, Zixuan Wei, Ming Qi, Wanbing Sun, Lu Zhang, Luo Chen, Xihui Gao, Ying Mao, Hao Wang, Liang Chen, Cong Li   +15 more
doaj   +1 more source

Kainate receptors and synaptic plasticity

Neuropharmacology, 2021
Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression.
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor   +3 more
openaire   +2 more sources

Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable

iScience
Summary: Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated
Yasmine Kamen, Kimberley Anne Evans, Yan Ting Ng, Sabine Dietmann, Ragnhildur Thóra Káradóttir   +4 more
doaj   +1 more source

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Cell Reports, 2017
Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley   +4 more
doaj   +1 more source