Results 21 to 30 of about 17,392 (217)
Kainate Receptors in Health and Disease [PDF]
Neuron, 2013 Our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology has progressed significantly over the last 30 years. A plethora of studies indicate that kainate receptors are important mediators of the pre- and postsynaptic actions of glutamate, although the mechanisms underlying such effects are still ...
Lerma, Juan, Marques, Joana M.
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Venom and toxins from Argiope lobata: electrophysiological studies
Біологічні студії, 2020 The purpose of this study was to present experimental data on the action of venom and toxins from Argiope lobata spiders on the glutamate channel-receptor complex.
O. M. Klyuchko
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Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice. [PDF]
PLoS ONE, 2010 Galanin is a neuropeptide with a wide distribution in the central and peripheral nervous systems and whose physiological effects are mediated through three G protein-coupled receptor subtypes, GalR1, GalR2, and GalR3.
P Elyse Schauwecker
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Molecules, 2022 The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases.
Agata Bartyzel +6 more
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Neurobiology of Disease, 1994 A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin +3 more
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Clathrin-independent but dynamin-dependent mechanisms mediate Ca2+-triggered endocytosis of the glutamate GluK2 receptor upon excitotoxicity [PDF]
Journal of Integrative Neuroscience, 2020 We first explore the features of GluK2 endocytosis during kainate excitotoxicity and then explore the role of Ca2+ in the regulation of GluK2 endocytosis. The roles of Ca2+ were examined by treating cells with Ca2+ inhibitors or chelators.
Jing-Jing Du, Lu Yan, Wei Zhang, Hao Xu, Qiu-Ju Zhu
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Kainate receptor modulation by NETO2
Nature, 2021 Glutamate-gated kainate receptors (KARs) are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission on post-synapse, and modulate transmitter release on pre-synapse. In the brain, the trafficking, gating kinetics, and pharmacology of KARs are tightly regulated by Neuropilin and tolloid-like proteins (Netos).
Lingli He +12 more
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AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells
Frontiers in Cellular Neuroscience, 2019 Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
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Neurobiology of Disease, 2014 Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study.
Asheebo Rojas +5 more
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Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains
eLife, 2017 Ion conductivity and the gating characteristics of tetrameric glutamate receptor ion channels are determined by their subunit composition. Competitive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling assembly.
Huaying Zhao +5 more
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