Results 11 to 20 of about 15,689 (185)
Trafficking of Kainate Receptors [PDF]
Membranes, 2014 Ionotropic glutamate receptors (iGluRs) mediate the vast majority of excitatory neurotransmission in the central nervous system of vertebrates. In the protein family of iGluRs, kainate receptors (KARs) comprise the probably least well understood receptor
Steffen Pahl +3 more
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Cochlear Kainate Receptors [PDF]
Journal of the Association for Research in Otolaryngology, 2012 Synaptic transmission between the cochlear hair cell and its afferent fiber is mediated by glutamate receptors. While kainate receptors are known to be present in the spiral ganglion, little is known of their distribution or functional role. We have detected all five kainate receptor subunits in the mouse cochlea with quantitative RT-PCR and with ...
Marcello, Peppi +2 more
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Kainate Receptors in Health and Disease [PDF]
Neuron, 2013 Our understanding of the molecular properties of kainate receptors and their involvement in synaptic physiology has progressed significantly over the last 30 years. A plethora of studies indicate that kainate receptors are important mediators of the pre- and postsynaptic actions of glutamate, although the mechanisms underlying such effects are still ...
Lerma, Juan, Marques, Joana M.
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Synaptic Targeting of Kainate Receptors [PDF]
Cerebral Cortex, 2014 When native and recombinant kainate receptors (KARs) are compared, there is a mismatch in several of their functional properties. While both generate currents, synaptic responses mediated by KARs have rarely observed in cultured hippocampal neurons.
Palacios-Filardo, Jon +2 more
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Venom and toxins from Argiope lobata: electrophysiological studies
Біологічні студії, 2020 The purpose of this study was to present experimental data on the action of venom and toxins from Argiope lobata spiders on the glutamate channel-receptor complex.
O. M. Klyuchko
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Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice. [PDF]
PLoS ONE, 2010 Galanin is a neuropeptide with a wide distribution in the central and peripheral nervous systems and whose physiological effects are mediated through three G protein-coupled receptor subtypes, GalR1, GalR2, and GalR3.
P Elyse Schauwecker
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Molecules, 2022 The blockade of kainate receptors, in particular with non-competitive antagonists, has—due to their anticonvulsant and neuroprotective properties—therapeutic potential in many central nervous system (CNS) diseases.
Agata Bartyzel +6 more
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Neurobiology of Disease, 1994 A minority subset of cortical neurones exhibit kainate-activated Co2+uptake, a marker for AMPA/kainate receptor gated Ca2+-permeable channels. Consistent with enhanced Ca2+influx through these channels, Co2+-positive neurones are unusually vulnerable to ...
Hong-zhen Yin +3 more
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Clathrin-independent but dynamin-dependent mechanisms mediate Ca2+-triggered endocytosis of the glutamate GluK2 receptor upon excitotoxicity [PDF]
Journal of Integrative Neuroscience, 2020 We first explore the features of GluK2 endocytosis during kainate excitotoxicity and then explore the role of Ca2+ in the regulation of GluK2 endocytosis. The roles of Ca2+ were examined by treating cells with Ca2+ inhibitors or chelators.
Jing-Jing Du, Lu Yan, Wei Zhang, Hao Xu, Qiu-Ju Zhu
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AMPA Receptor-Mediated Ca2+ Transients in Mouse Olfactory Ensheathing Cells
Frontiers in Cellular Neuroscience, 2019 Ca2+ signaling in glial cells is primarily triggered by metabotropic pathways and the subsequent Ca2+ release from internal Ca2+ stores. However, there is upcoming evidence that various ion channels might also initiate Ca2+ rises in glial cells by Ca2 ...
Antonia Beiersdorfer, Christian Lohr
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