GluK2 kainate receptor subunit-selective, potentiating RNA aptamer [PDF]
Scientific ReportsKainate receptors are a subtype of ionotropic glutamate receptors. Potent and selective modulatory agents of kainate receptors are potential drug candidates for treatment of various neurological diseases involving receptor dysregulation.
Samantha R. Ingenito +3 more
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Structural insights into kainate receptor desensitization [PDF]
Nature CommunicationsKainate receptors (KARs) belong to the ionotropic glutamate receptor (iGluR) family and play critical roles in mediating excitatory neurotransmission and regulating neurotransmitter release.
Changping Zhou +2 more
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Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice [PDF]
Cell Reports, 2017 Kainate receptors are members of the glutamate receptor family that regulate synaptic function in the brain. They modulate synaptic transmission and the excitability of neurons; however, their contributions to neural circuits that underlie behavior are ...
Jian Xu +10 more
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Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor
Cell Reports, 2016 Synaptic communication between neurons requires the precise localization of neurotransmitter receptors to the correct synapse type. Kainate-type glutamate receptors restrict synaptic localization that is determined by the afferent presynaptic connection.
Christoph Straub +10 more
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A kainate receptor–selective RNA aptamer [PDF]
Journal of Biological Chemistry, 2020 Li Niu
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Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors
Membranes, 2021 Kainate receptors are members of the ionotropic glutamate receptor family. They form cation-specific transmembrane channels upon binding glutamate that desensitize in the continued presence of agonists.
Cuauhtemoc U. Gonzalez +3 more
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Mitochondrial superoxide production and MnSOD activity following exposure to an agonist and antagonists of ionotropic receptors in rat brain [PDF]
Archives of Biological Sciences, 2005 The involvement of NMDA and AMPA/kainate receptors in the induction of superoxide production in the rat brain was examined after intrahippocampal injection of kainate, a non-NMDA receptor agonist; kainate plus CNQX, a selective AMPA/kainate receptor ...
Radenović Lidija Lj., Selaković Vesna
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Effect of glutamate antagonists on nitric oxide production in rat brain following intrahippocampal injection [PDF]
Archives of Biological Sciences, 2007 Stimulation of glutamate receptors induces neuronal nitric oxide (NO) release, which in turn modulates glutamate transmission. The involvement of ionotropic glutamate NMDA and AMPA/kainate receptors in induction of NO production in the rat brain was ...
Radenović Lidija +3 more
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Perampanel inhibition of AMPA receptor currents in cultured hippocampal neurons. [PDF]
PLoS ONE, 2014 Perampanel is an aryl substituted 2-pyridone AMPA receptor antagonist that was recently approved as a treatment for epilepsy. The drug potently inhibits AMPA receptor responses but the mode of block has not been characterized.
Chao-Yin Chen +3 more
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Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfactory bulb. [PDF]
PLoS ONE, 2008 Although synaptic functions of ionotropic glutamate receptors in the olfactory bulb have been studied in vitro, their roles in pattern processing in the intact system remain controversial.
Rico Tabor, Rainer W Friedrich
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