Results 31 to 40 of about 18,286 (218)

Ca2+ Influx through AMPA or Kainate Receptors Alone Is Sufficient to Initiate Excitotoxicity in Cultured Oligodendrocytes

Neurobiology of Disease, 2002
Oligodendrocytes are vulnerable to excitotoxic insults mediated by AMPA receptors and by low and high affinity kainate receptors, a feature that is dependent on Ca2+ influx.
Elena Alberdi, Marı́a Victoria Sánchez-Gómez, Aida Marino, Carlos Matute   +3 more
doaj   +1 more source

Alterations in kainate receptor and TRPM1 localization in bipolar cells after retinal photoreceptor degeneration

Frontiers in Cellular Neuroscience, 2015
Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear ...
Jacqueline eGayet-Primo, Theresa ePuthussery   +1 more
doaj   +1 more source

Regulation of GABA(A) and glutamate receptor expression, synaptic facilitation and long-term potentiation in the hippocampus of prion mutant mice [PDF]

, 2009
Background: Prionopathies are characterized by spongiform brain degeneration, myoclonia, dementia, and periodic electroencephalographic (EEG) disturbances.
Delgado-García, J. M., Llorens Torres, Franc, Rangel, Alejandra (R17729), Madroñal, Noelia, Rangel Rincones, Alejandra Helena, Rangel, A., Del Río, J. A., Llorens, Franc, Lauro Sumoy, Madroñal, N., Torres Juan María, Torres, Juan M., Sumoy, Lauro, Alejandra Rangel, Rosalina Gavín, Gruart i Massó, Agnès, Massó Agnès Gruart i., Llorens Franc, Noelia Madroñal, Río José Antonio Del, Juan María Torres, Gavin, Rosalina, Agnès Gruart, Gruart i Massó, A., Sumoy, L., Rangel Alejandra, Gavín Rosalina, Madroñal Noelia, Delgado-Garcia, Jose M., Franc Llorens, José Antonio Del Río, Sumoy Lauro, Río Fernández, José Antonio del, Torres, Juan María, Gavín Marín, Rosalina, José María Delgado-García, Agnès Gruart i. Massó, Rio, Jose A. del, Delgado-García José María, Delgado García, José M.   +39 more
core   +1 more source

Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy

EBioMedicine, 2021
Background: In the setting of drug-resistant epilepsy (DRE), the success of surgery depends on the ability to accurately locate the epileptic foci to be resected or disconnected.
Cong Wang, Jianping Zhang, Shaoli Song, Zhi Li, Shujie Yin, Wenjia Duan, Zixuan Wei, Ming Qi, Wanbing Sun, Lu Zhang, Luo Chen, Xihui Gao, Ying Mao, Hao Wang, Liang Chen, Cong Li   +15 more
doaj   +1 more source

Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4)

, 2012
Proteinase-activated receptors 4 (PAR(4)) is a class A G protein-coupled receptor (GPCR) recognized through the ability of serine proteases such as thrombin and trypsin to mediate receptor activation. Due to the irreversible nature of activation, a fresh
Robben, Joris, Cooke, Alexandra, Gould, Gwyn W., McIntosh, Kathryn A., Gould, Gwyn, Milligan, Graeme, Cunningham, Margaret Rose, Pediani, John D., Cooke, Alexandra E., McIntosh, Kathryn, Nilsson, Mary, Mundell, Stuart, Plevin, Robin, Cunningham, Margaret R., McIntosh, Kathryn A, Pediani, John D, Gould, Gwyn W, Pediani, John, Nilsson, Mary Francis, Cunningham, Margaret R, Cooke, Alexandra E   +20 more
core   +1 more source

Kainate receptors and synaptic plasticity

Neuropharmacology, 2021
Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression.
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor   +3 more
openaire   +2 more sources

Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable

iScience
Summary: Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated
Yasmine Kamen, Kimberley Anne Evans, Yan Ting Ng, Sabine Dietmann, Ragnhildur Thóra Káradóttir   +4 more
doaj   +1 more source

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Cell Reports, 2017
Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley   +4 more
doaj   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

, 2016
Ionotropic glutamate receptors play a key role for fast neurotransmission in the central nervous system and have been linked to several neurological diseases and disorders.
Frydenvang, Karla Andrea, Kristensen, Ole, Pickering, Darryl S, Kristensen, Lise Baadsgaard, Møllerud, Stine, Kastrup, Jette Sandholm Jensen   +5 more
core   +1 more source