Results 31 to 40 of about 17,392 (217)

AMPA and Kainate Receptors Each Mediate Excitotoxicity in Oligodendroglial Cultures

Neurobiology of Disease, 1999
Recent studies indicate that oligodendrocytes are vulnerable to excitotoxic insults mediated by glutamate receptors. The present study was carried out to characterize the type of glutamate receptors triggering cell death in optic nerve oligodendrocyte ...
Maria Victoria Sánchez-Gómez, Carlos Matute   +1 more
doaj   +1 more source

Ca2+ Influx through AMPA or Kainate Receptors Alone Is Sufficient to Initiate Excitotoxicity in Cultured Oligodendrocytes

Neurobiology of Disease, 2002
Oligodendrocytes are vulnerable to excitotoxic insults mediated by AMPA receptors and by low and high affinity kainate receptors, a feature that is dependent on Ca2+ influx.
Elena Alberdi, Marı́a Victoria Sánchez-Gómez, Aida Marino, Carlos Matute   +3 more
doaj   +1 more source

Alterations in kainate receptor and TRPM1 localization in bipolar cells after retinal photoreceptor degeneration

Frontiers in Cellular Neuroscience, 2015
Photoreceptor degeneration differentially impacts glutamatergic signaling in downstream On and Off bipolar cells. In rodent models, photoreceptor degeneration leads to loss of glutamatergic signaling in On bipolar cells, whereas Off bipolar cells appear ...
Jacqueline eGayet-Primo, Theresa ePuthussery   +1 more
doaj   +1 more source

Kainate receptor physiology

Current Opinion in Pharmacology, 2006
Glutamate receptors constitute a complex signalling system at most of the excitatory synapses in the brain. Of the known ionotropic glutamate receptors, kainate receptors are ubiquitous in the central nervous system, and a considerable amount of data indicates that this class of receptors is present at both sides of the synapse.
openaire   +3 more sources

Kainate receptors and synaptic plasticity

Neuropharmacology, 2021
Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression.
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor   +3 more
openaire   +2 more sources

Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable

iScience
Summary: Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated
Yasmine Kamen, Kimberley Anne Evans, Yan Ting Ng, Sabine Dietmann, Ragnhildur Thóra Káradóttir   +4 more
doaj   +1 more source

Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy

EBioMedicine, 2021
Background: In the setting of drug-resistant epilepsy (DRE), the success of surgery depends on the ability to accurately locate the epileptic foci to be resected or disconnected.
Cong Wang, Jianping Zhang, Shaoli Song, Zhi Li, Shujie Yin, Wenjia Duan, Zixuan Wei, Ming Qi, Wanbing Sun, Lu Zhang, Luo Chen, Xihui Gao, Ying Mao, Hao Wang, Liang Chen, Cong Li   +15 more
doaj   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

RNA Editing at the Q/R Site for the Glutamate Receptor Subunits GLUR2, GLUR5, and GLUR6 in Hippocampus and Temporal Cortex from Epileptic Patients

Neurobiology of Disease, 2001
Posttranscriptional editing of mRNA is a phenomenon that generates molecular heterogeneity and functional variety. With the intention to test if RNA editing plays a role in pathological processes, which contribute to seizure maintenance, we examined the ...
G. Kortenbruck, E. Berger, E.-J. Speckmann, U. Musshoff   +3 more
doaj   +1 more source

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source