Results 31 to 40 of about 1,356,843 (204)

Imaging epileptic foci in mouse models via a low-density lipoprotein receptor-related protein-1 targeting strategy

EBioMedicine, 2021
Background: In the setting of drug-resistant epilepsy (DRE), the success of surgery depends on the ability to accurately locate the epileptic foci to be resected or disconnected.
Cong Wang, Jianping Zhang, Shaoli Song, Zhi Li, Shujie Yin, Wenjia Duan, Zixuan Wei, Ming Qi, Wanbing Sun, Lu Zhang, Luo Chen, Xihui Gao, Ying Mao, Hao Wang, Liang Chen, Cong Li   +15 more
doaj   +1 more source

Functional Validation of Heteromeric Kainate Receptor Models. [PDF]

Biophys J, 2017
Kainate receptors require the presence of external ions for gating. Most work thus far has been performed on homomeric GluK2 but, in vivo, kainate receptors are likely heterotetramers. Agonists bind to the ligand-binding domain (LBD) which is arranged as
Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC.   +4 more
europepmc   +2 more sources

Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable

iScience
Summary: Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated
Yasmine Kamen, Kimberley Anne Evans, Yan Ting Ng, Sabine Dietmann, Ragnhildur Thóra Káradóttir   +4 more
doaj   +1 more source

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Cell Reports, 2017
Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley   +4 more
doaj   +1 more source

Kainate receptor function in rodent subcortical visual processing. [PDF]

, 2007
Glutamate is found throughout the central nervous system and has been shown to be an important excitatory neurotransmitter in the visual system. There are two subdivisions of receptor on which this ubiquitous neurotransmitter acts, metabotropic (mGluR ...
Pothecary, C.A.
core  

Structure of a High-Affinity Kainate Receptor: GluK4 Ligand-Binding Domain Crystallized with Kainate

, 2016
Ionotropic glutamate receptors play a key role for fast neurotransmission in the central nervous system and have been linked to several neurological diseases and disorders.
Frydenvang, Karla Andrea, Kristensen, Ole, Pickering, Darryl S, Kristensen, Lise Baadsgaard, Møllerud, Stine, Kastrup, Jette Sandholm Jensen   +5 more
core   +1 more source

Do preclinical seizure models predict success or failure in anti‐seizure drug development? A retrospective analysis of 89 compounds with divergent clinical outcomes for epilepsy

Epilepsia, EarlyView.
Abstract Anti‐seizure medication (ASM) discovery remains a major challenge despite over 30 commercially available options. One persistent obstacle for any promising candidate compound to successfully move from preclinical study to clinical approval has been the ambiguity in preclinical model selection.
Wolfgang Löscher, Melissa Barker‐Haliski   +1 more
wiley   +1 more source

RNA Editing at the Q/R Site for the Glutamate Receptor Subunits GLUR2, GLUR5, and GLUR6 in Hippocampus and Temporal Cortex from Epileptic Patients

Neurobiology of Disease, 2001
Posttranscriptional editing of mRNA is a phenomenon that generates molecular heterogeneity and functional variety. With the intention to test if RNA editing plays a role in pathological processes, which contribute to seizure maintenance, we examined the ...
G. Kortenbruck, E. Berger, E.-J. Speckmann, U. Musshoff   +3 more
doaj   +1 more source

Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology [PDF]

, 2009
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
core  

The effects of antidepressant drugs on kainate receptor mRNA levels

, 1991
We have measured the levels of kainate receptor mRNA in rat brains following the injection of antidepressant drugs over a time course up to 32 days. Over this period imipramine and fluvoxamine elicited a rise in kainate receptor mRNA levels to a maximum ...
Buckland, Paul Robert, O'Donovan, Michael Conlon, McGuffin, Peter, Havard, H. L.   +3 more
core   +1 more source