Results 61 to 70 of about 1,356,843 (204)

Neto Auxiliary Subunits Regulate Interneuron Somatodendritic and Presynaptic Kainate Receptors to Control Network Inhibition

Cell Reports, 2017
Although Netos are considered auxiliary subunits critical for kainate receptor (KAR) function, direct evidence for their regulation of native KARs is limited.
Megan S. Wyeth, Kenneth A. Pelkey, Xiaoqing Yuan, Geoffrey Vargish, April D. Johnston, Steven Hunt, Calvin Fang, Daniel Abebe, Vivek Mahadevan, André Fisahn, Michael W. Salter, Roderick R. McInnes, Ramesh Chittajallu, Chris J. McBain   +13 more
doaj   +1 more source

N‐methyl‐D‐aspartate receptor antagonists for controlling pain in dogs

Journal of Small Animal Practice, EarlyView.
This is a mini review published by the World Small Animal Veterinary Association's Pain Committee. This article provides an assessment of the scientific evidence of N‐methyl‐d‐aspartate receptor antagonists for controlling pain in dogs while identifying current knowledge gaps.
P. W. Kronen, B. D. X. Lascelles, B. P. Monteiro, J. C. Murrell, S. A. Robertson, P. V. Steagall, B. Wright   +6 more
wiley   +1 more source

Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells. [PDF]

PLoS ONE, 2014
Nitric oxide (NO) is involved in retinal signal processing, but its cellular actions are only partly understood. An established source of retinal NO are NOACs, a group of nNOS-expressing amacrine cells which signal onto bipolar, other amacrine and ...
Alex H Vielma, Adolfo Agurto, Joaquín Valdés, Adrián G Palacios, Oliver Schmachtenberg   +4 more
doaj   +1 more source

TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley   +1 more source

Neu2000 Potentiates a Kainate Response in Mouse Cortical Neurons

Journal of Pharmacological Sciences, 2013
Neu2000, acting as an antioxidant with N-methyl-d-aspartate–receptor antagonism, demonstrates excellent protection against ischemic insults in rodents.
Jihyun Noh, Jun-mo Chung
doaj   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Conservation of a synaptic blueprint across the animal kingdom

The Journal of Physiology, EarlyView.
Abstract figure legend Conservation of synaptic nanostructure and function across species. Several components of synaptic organization and function in diverse species shown on the left are largely conserved based on a ‘synaptic blueprint’ or essential framework required to achieve the spatial and temporal fidelity of synaptic transmission.
Aiden J. Houcek, Ege T. Kavalali
wiley   +1 more source

Astrocytic EAAT‐2 Upregulation Supports Neuro‐Axonal Homeostasis in Chronic Inflammatory CNS Lesions

Glia, Volume 74, Issue 12, December 2026.
Inflammatory CNS lesions increase extracellular glutamate. Astrocytic EAAT regulation controls glutamate clearance, stabilizes axonal Ca2+ homeostasis, and determines neurite survival during chronic neuroinflammation. ABSTRACT Neuronal loss in multiple sclerosis (MS) is a key factor in the progression of disability.
Luise Reukauf, Anca Margineanu, Bakhrom Muinjonov, Jessy Chen, Yiqin Cui, Kamil Rosiewicz, Helena Radbruch, Ian Munro, Marlen Alisch, Volker Siffrin   +9 more
wiley   +1 more source

Cu/Zn-superoxide dismutase (GLY93→ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture

Neurobiology of Disease, 2004
The cause of the selective degeneration of motor neurons in amyotrophic lateral sclerosis (ALS) remains a mystery. One potential pathogenic mechanism is excitotoxicity due to disturbances of glutamatergic neurotransmission, particularly via AMPA ...
Alida Spalloni, Federica Albo, Francesca Ferrari, Nicola Mercuri, Giorgio Bernardi, Cristina Zona, Patrizia Longone   +6 more
doaj   +1 more source

NMDA receptor subunit‐dependent analysis of radiprodil inhibition in neonatal male rat substantia nigra dopaminergic neurons

British Journal of Pharmacology, Volume 183, Issue 23, Page 6767-6786, December 2026.
Abstract Background and Purpose Radiprodil is a GluN2B subunit selective NMDA receptor negative allosteric modulator which is currently under clinical investigation as a possible anti‐epileptic drug for paediatric use. Our goal was to investigate the inhibition of dopaminergic neuron NMDA responses by radiprodil.
Bangyuan Liu, Alasdair J. Gibb
wiley   +1 more source