Results 61 to 70 of about 17,392 (217)

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Kainate receptors: on the dark side [PDF]

The Journal of Physiology, 2014
Synaptic glutamate receptors can be divided into metabotropic receptors, an eight-member GPCR family, and ionotropic glutamate receptors, a three-member family of NMDA, kainate, and AMPA tetrameric receptors. The most neglected are the five subunit (GluK1–5) kainate receptors, often either lumped with the AMPA receptors because of pharmacological ...
openaire   +2 more sources

Kainate receptor trafficking [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2011
AbstractKainate receptors (KARs) are ligand‐gated ion channels that can regulate neuronal network activity and are involved in processes ranging from neuronal development and differentiation to neurodegeneration and neuronal cell death. They are tetrameric assemblies which can comprise different subunit combinations and are differentially targeted to ...
Inmaculada M. González‐González, Filip A. Konopacki, Daniel L. Rocca, Andrew J. Doherty, Nadia Jaafari, Kevin A. Wilkinson, Jeremy M. Henley   +6 more
openaire   +1 more source

Apoptosis and Glial Marker Profiles in Hippocampus and Amygdala of Medically Intractable Temporal Lobe Epilepsy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 10, May 2026.
ABSTRACT Medically intractable temporal lobe epilepsy is associated with potential neuronal and glial damage in key brain structures, including the hippocampus and amygdala. This study aimed to examine apoptosis, caspase expression, and glial activation markers in these regions, and to evaluate their associations with clinical variables.
Fatemeh Alipour, Sayed Mostafa Modarres Mousavi, Farshid Nourbaksh, Masoud Ghadipasha, Jaber Gharehdaghi, Christoph Kellinghaus, Erwin‐Josef Speckmann, Walter Stummer, Ali Gorji, Maryam Khaleghi Ghadiri   +9 more
wiley   +1 more source

Cu/Zn-superoxide dismutase (GLY93→ALA) mutation alters AMPA receptor subunit expression and function and potentiates kainate-mediated toxicity in motor neurons in culture

Neurobiology of Disease, 2004
The cause of the selective degeneration of motor neurons in amyotrophic lateral sclerosis (ALS) remains a mystery. One potential pathogenic mechanism is excitotoxicity due to disturbances of glutamatergic neurotransmission, particularly via AMPA ...
Alida Spalloni, Federica Albo, Francesca Ferrari, Nicola Mercuri, Giorgio Bernardi, Cristina Zona, Patrizia Longone   +6 more
doaj   +1 more source

GLP‐1 at the Metabolic–Cognitive Interface: Reward, Affect, and Memory

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
GLP‐1R signaling integrates metabolic state with neural circuits controlling reward, mood, and memory, acting as a metabolic‐cognitive interface. In reward pathways, it suppresses hedonic feeding and drug seeking; in affective circuits, sustained signaling promotes anxiolytic and antidepressant effects; and in the hippocampus, it enhances synaptic ...
Serena X. Gao, Léa Décarie‐Spain, Cindy Gu, Giulia Mazzini, Scott E. Kanoski, Tito Borner   +5 more
wiley   +1 more source

Assembly Stoichiometry of the GluK2/GluK5 Kainate Receptor Complex

Cell Reports, 2012
Ionotropic glutamate receptors assemble as homo- or heterotetramers. One well-studied heteromeric complex is formed by the kainate receptor subunits GluK2 and GluK5.
Andreas Reiner, Ryan J. Arant, Ehud Y. Isacoff   +2 more
doaj   +1 more source

Synchrotron‐generated microbeams as a radiosurgical alternative for drug‐resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy

Epilepsia, Volume 67, Issue 4, Page 1614-1626, April 2026.
Abstract Objective One‐third of patients with epilepsy, particularly those with mesial temporal lobe epilepsy (MTLE), remain resistant to medication. Resective surgery, the gold standard, is highly invasive and carries significant risks. Here, using a mouse model, we explored the potential of microbeam radiation therapy (MRT), a new technique based on ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean‐François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis   +8 more
wiley   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

Neuroprotection by urokinase plasminogen activator in the hippocampus

Neurobiology of Disease, 2012
Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences
Eunsil Cho, Kyung Jin Lee, Jung-Woo Seo, Catherine Jeonghae Byun, Sun-Ju Chung, Dae Chul Suh, Peter Carmeliet, Jae-Young Koh, Jong S. Kim, Joo-Yong Lee   +9 more
doaj   +1 more source