Results 81 to 90 of about 18,286 (218)

Neuroprotection by urokinase plasminogen activator in the hippocampus

Neurobiology of Disease, 2012
Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences
Eunsil Cho, Kyung Jin Lee, Jung-Woo Seo, Catherine Jeonghae Byun, Sun-Ju Chung, Dae Chul Suh, Peter Carmeliet, Jae-Young Koh, Jong S. Kim, Joo-Yong Lee   +9 more
doaj   +1 more source

Proteomic Profiling of Primary Hippocampal Neurons Reveals Noncanonical GFAP Expression and Metabolic Adaptations in Glia‐Free Culture

PROTEOMICS, Volume 26, Issue 7, Page 111-130, July 2026.
ABSTRACT Despite their widespread use as a research model, a comprehensive, quantitative proteomic profile of the cultured hippocampal neurons has remained unexplored. Here, we provide the first global proteomic characterization of primary murine hippocampal neurons cultured for 14 days under near‐physiological glucose conditions (2.5 mM).
Dominika Drulis‐Fajdasz, Kinga Gostomska‐Pampuch, Natalia Pudełko‐Malik, Mariusz Fleszar, Agnieszka Gizak, Jacek R. Wiśniewski, Dariusz Rakus   +6 more
wiley   +1 more source

Involvement of kainate glutamate receptors in the modulation of neuronal transmission in brain areas involved in migraine pathophysiology

, 2009
Migraine pathophysiology is thought to involve activation of the trigeminal fibres which innervate dural structures. The nociceptive inflow from the meninges is relayed to the trigeminocervical complex (TCC), before ascending to higher brain areas ...
Andreou, A.
core  

Role of kainate receptor activation and desensitization on the [Ca2+]i changes in cultured rat hippocampal neurons [PDF]

, 2001
We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca2+ concentration ([Ca2+]i) in individual cultured rat hippocampal neurons.
Salgado, António J., Silva, Ana P., Carvalho, Arsélio P., Ambrósio, António F., Malva, João O., Carvalho, Caetana M.   +5 more
core   +1 more source

Impact of Voluntary Alcohol Consumption on Corticostriatal Plasticity in Rats

European Journal of Neuroscience, Volume 64, Issue 1, July 2026.
After 8 weeks voluntary alcohol consumption, AMPA/NMDA ratios were reduced in medium spiny neurons in the dorsolateral striatum, upon optogenetic stimulation of sensorimotor cortical inputs. Moreover, coefficient of variance was reduced and paired‐pulse facilitation was enhanced, selectively in high alcohol drinking rats.
Johanna A. S. Smeets, Geert M. J. Ramakers, Frank J. Meye, Anne‐Marie Baars, Roger A. H. Adan, Louk J. M. J. Vanderschuren, Heidi M. B. Lesscher   +6 more
wiley   +1 more source

Kainate Receptor-mediated Regulation of Chloride Homeostasis

, 2019
A balance between excitatory and inhibitory activity is needed to maintain proper brain function. At inhibitory synapses, potassium-chloride cotransporter 2 (KCC2) has long been known to be a critical regulator of inhibition through its ability to ...
Garand, Danielle
core   +1 more source

Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis

Neurobiology of Disease, 2007
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated excitotoxicity contributes to the selective motor neuron death in amyotrophic lateral sclerosis (ALS).
Maria Andries, Philip Van Damme, Wim Robberecht, Ludo Van Den Bosch   +3 more
doaj   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Electrophysiological studies of Nephila clavata venom and toxin influence on hippocampal neuronal membranes after pretreatment with Aspergillus oryzae proteases

Біологічні студії, 2020
Background. The use of Arthropodae toxins for electrophysiological experiments is very important, but experimental data in this regard are scarce. The aim of this study was to obtain experimental data about the influence of Nephila clavata spider venom ...
O. M. Klyuchko
doaj   +1 more source

Unbalanced dendritic inhibition of CA1 neurons drives spatial-memory deficits in the Ts2Cje Down syndrome model

Nature Communications, 2019
Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of ...
Sergio Valbuena, Álvaro García, Wilfrid Mazier, Ana V. Paternain, Juan Lerma   +4 more
doaj   +1 more source