Results 81 to 90 of about 1,356,843 (204)
Ketogenic Diet–Associated Remodeling of the Cortical Proteome in Rats With Genetic Absence Epilepsy
Brain and Behavior, Volume 16, Issue 10, October 2026.Proteomic profiling of the somatosensory cortex revealed that ketogenic diet was associated with remodeling of cortical protein networks in GAERS absence epilepsy, with altered proteins enriched in synaptic and mitochondrial pathways. ABSTRACT Purpose This study investigated the effects of ketogenic diet (KD) intervention on the cortical proteome in ...
Aslihan Gunel +8 more
wiley +1 more source
Біологічні студії, 2020 Background. The use of Arthropodae toxins for electrophysiological experiments is very important, but experimental data in this regard are scarce. The aim of this study was to obtain experimental data about the influence of Nephila clavata spider venom ...
O. M. Klyuchko
doaj +1 more source
Nature Communications, 2019 Exaggerated synaptic inhibition is hypothesised to be a main cause of cognitive deficits in Down syndrome models. The authors identify triplication of the kainate receptor encoding gene Grik1 as the cause of memory deficits due to a reorganization of ...
Sergio Valbuena +4 more
doaj +1 more source
Decrease in tobacco consumption after treatment with topiramate and aripiprazole: a case report
Journal of Medical Case Reports, 2008 Introduction A large part of research into drug addiction focuses on mesolimbic dopamine circuitry; however, both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid and/or kainate and dopamine D2 receptors can play a role in maintaining the ...
Arbaizar Beatriz +2 more
doaj +1 more source
Structure and gating of kainate receptors
Frontiers in PharmacologyIonotropic glutamate receptors (iGluRs) are crucial for fast excitatory neurotransmission in the mammalian central nervous system (CNS). Kainate receptors (KARs), a subclass of iGluRs, are tetrameric, ligand-gated ion channels that play key modulatory roles at both pre- and post-synaptic sites within neuronal circuits and in the regulation of synaptic ...
Gangwar, Shanti P. +4 more
openaire +3 more sources
Presynaptic Kainate Receptors Regulate Spinal Sensory Transmission
, 2001 Small diameter dorsal root ganglion (DRG) neurons, which include cells that transmit nociceptive information into the spinal cord, are known to express functional kainate receptors.
Timothy J. Wilding +4 more
core +1 more source
GluK2-mediated excitability within the superficial layers of the entorhinal cortex.
PLoS ONE, 2009 Recent analysis of genetically modified mice deficient in different kainate receptor (KAR) subunits have strongly pointed to a role of the GluK2 subunit, mediating the vulnerability of the brain towards seizures.
Prateep S Beed +2 more
doaj +1 more source
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures
Neurobiology of Disease, 2015 The aim of this study was to investigate the role of the synaptic metabotropic zinc receptor mZnR/GPR39 in physiological adaptation to epileptic seizures.
David Gilad +6 more
doaj +1 more source
Frontiers in Neural Circuits, 2013 Dentate granule cells process information from the enthorinal cortex en route to the hippocampus proper. These neurons have a very negative resting membrane potential and are relatively silent in the slice preparation.
Arnaud J Ruiz, Dimitri M Kullmann
doaj +1 more source
Cloning of a putative glutamate receptor : a low affinity kainate-binding subunit
, 1992 Kainate, a glutamate receptor agonist, is a potent neuroexcitatory agent that produces epileptiform activity and selective neuronal degeneration. Binding studies using neuronal membrane homogenates or brain sections have identified sites having either ...
Stevens, C. F. +7 more
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