Results 151 to 160 of about 15,707 (217)

Influence of anti-inflammatory interventions in the Kainic acid model of hippocampal excitotoxicity

, 2010
Lorna C. Gleeson
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Anti-epileptic and Neuroprotective Effects of Ultra-low Dose NADPH Oxidase Inhibitor Dextromethorphan on Kainic Acid-induced Chronic Temporal Lobe Epilepsy in Rats. [PDF]

Neurosci Bull
Yang JJ, Liu YX, Wang YF, Ge BY, Wang Y, Wang QS, Li S, Zhang JJ, Jin LL, Hong JS, Yin SM, Zhao J.   +11 more
europepmc   +1 more source

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3H-kainic acid binding: Relevance for evaluating the neurotoxicity of kainic acid

Life Sciences, 1979
Abstract Binding of 3 H-kainic acid (KA) to brain membranes is saturable (K D = 72 nM) and displays markes specificity for compounds that bear relation to excitatory amino acids. Its regional distribution correlates roughly with the regional neurotoxicity of in situ KA injections. Striatal kainate lesions, but not interruption of striatal afferents,
R, Schwarcz, K, Fuxe
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Kainic acid neurotoxicity and seizures

Neuropharmacology, 1981
Abstract The effects of anesthetics and anticonvulsants on the neurotoxic effects of kainic acid (2.3 nmol) injected into the rat hippocampus and striatum have been examined with regard to neurochemical, histological and electroencephalographic alterations.
R, Zaczek, M, Nelson, J T, Coyle
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Kainic acid induces apoptosis in neurons

Neuroscience, 1996
Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood.
N A, Simonian, R L, Getz, J C, Leveque, C, Konradi, J T, Coyle   +4 more
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Detoxification enzymes following intrastriatal kainic acid

Neurochemical Research, 1987
A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxygen metabolites is accomplished.
M R, Cohen, C N, Ramchand, V, Sailer, M, Fernandez, W, McAmis, N, Sridhara, C, Alston   +6 more
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Short Total Synthesis of (−)-Kainic Acid

Organic Letters, 2014
A short total synthesis of (-)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition-cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (-)-kainic acid via the stereoselective 1,4-reduction of the pyrroline ...
Kentaro, Oe, Yasufumi, Ohfune, Tetsuro, Shinada   +2 more
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Photostability of Kainic Acid in Seawater

Journal of Agricultural and Food Chemistry, 2007
The environmental degradation of a mixture of domoic acid (DA) and kainic acid (KA) in seawater with and without added transition metals is reported. The association constants for kainic acid with Fe (III) and Cu (II) were determined using (1)H nuclear magnetic resonance (NMR; K1,Fe(III) = 2.27 x 10(12), K2,Fe(III) = 8.99 x 10(8), K1,Cu(II) = 1.38 x 10(
Justina M, Burns, Tracey B, Schock, Michelle H, Hsia, Peter D R, Moeller, John L, Ferry   +4 more
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Stereocontrolled Total Synthesis of (−)-Kainic Acid

Organic Letters, 2007
[reaction: see text] A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity.
Hiroshi, Sakaguchi, Hidetoshi, Tokuyama, Tohru, Fukuyama   +2 more
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