Results 161 to 170 of about 15,680 (217)

3H-kainic acid binding: Relevance for evaluating the neurotoxicity of kainic acid

Life Sciences, 1979
Abstract Binding of 3 H-kainic acid (KA) to brain membranes is saturable (K D = 72 nM) and displays markes specificity for compounds that bear relation to excitatory amino acids. Its regional distribution correlates roughly with the regional neurotoxicity of in situ KA injections. Striatal kainate lesions, but not interruption of striatal afferents,
R, Schwarcz, K, Fuxe
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Photostability of Kainic Acid in Seawater

Journal of Agricultural and Food Chemistry, 2007
The environmental degradation of a mixture of domoic acid (DA) and kainic acid (KA) in seawater with and without added transition metals is reported. The association constants for kainic acid with Fe (III) and Cu (II) were determined using (1)H nuclear magnetic resonance (NMR; K1,Fe(III) = 2.27 x 10(12), K2,Fe(III) = 8.99 x 10(8), K1,Cu(II) = 1.38 x 10(
Justina M, Burns, Tracey B, Schock, Michelle H, Hsia, Peter D R, Moeller, John L, Ferry   +4 more
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The mechanism of kainic acid neurotoxicity

Nature, 1983
The putative excitatory transmitters glutamate and aspartate, as well as their excitatory analogues, can kill neurones in the central nervous system and may thus be involved in the pathogenesis of various neurodegenerative disorders. Several studies have suggested that postsynaptic receptors are important in the mechanism of toxicity.
J, Garthwaite, G, Garthwaite
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A Concise Route to (−)-Kainic Acid

Organic Letters, 2000
A concise route to (-)-kainic acid from enantiopure (+)-cis-4-carbobenzoxyamino-2-cyclopentenol has been devised by employing concurrent Chugaev syn-elimination and intramolecular ene reaction as the key step.
H, Nakagawa, T, Sugahara, K, Ogasawara
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Kainic acid neurotoxicity and seizures

Neuropharmacology, 1981
Abstract The effects of anesthetics and anticonvulsants on the neurotoxic effects of kainic acid (2.3 nmol) injected into the rat hippocampus and striatum have been examined with regard to neurochemical, histological and electroencephalographic alterations.
R, Zaczek, M, Nelson, J T, Coyle
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Kainic acid induces apoptosis in neurons

Neuroscience, 1996
Growing evidence suggests that non-N-methyl-D-aspartate receptor activation may contribute to neuronal death in both acute and chronic neurological diseases. The intracellular processes that mediate this form of neuronal death are poorly understood.
N A, Simonian, R L, Getz, J C, Leveque, C, Konradi, J T, Coyle   +4 more
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Stereocontrolled Total Synthesis of (−)-Kainic Acid

Organic Letters, 2007
[reaction: see text] A stereocontrolled total synthesis of (-)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the resultant alpha,beta-unsaturated lactone with high diastereoselectivity.
Hiroshi, Sakaguchi, Hidetoshi, Tokuyama, Tohru, Fukuyama   +2 more
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Short Total Synthesis of (−)-Kainic Acid

Organic Letters, 2014
A short total synthesis of (-)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition-cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral pyrroline was converted to (-)-kainic acid via the stereoselective 1,4-reduction of the pyrroline ...
Kentaro, Oe, Yasufumi, Ohfune, Tetsuro, Shinada   +2 more
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Action of kainic acid on a glutamatergic synapse

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1975
Abstract 1. The effect of kainic acid on the locust excitatory nerve-muscle junction was investigated. 2. Kainic acid increased the amplitude of the excitatory postsynaptic potential (EPSP) at a threshold concentration of 5 × 10−5 M. 3. Kainic acid at 10−5 M potentiated the glutamate potential and increased the miniature EPSP frequency without ...
A, Daoud, P N, Usherwood
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Ethanol, baclofen, and kainic acid neurotoxicity

Experimental Neurology, 1980
Abstract The neurotoxicity induced by intrastriatal injections of kainic acid was greater in rats drinking approximately 4 ml ethanol per day for 16 days before injection than in controls. Intraperitoneal injection of 5 mg/kg baclofen (parachlorophenyl GABA), 30 min before the kainic acid injections had a slight protective action.
E G, McGeer, A, Jakubovic, E A, Singh
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