Results 161 to 170 of about 15,707 (217)

A Concise Route to (−)-Kainic Acid

Organic Letters, 2000
A concise route to (-)-kainic acid from enantiopure (+)-cis-4-carbobenzoxyamino-2-cyclopentenol has been devised by employing concurrent Chugaev syn-elimination and intramolecular ene reaction as the key step.
H, Nakagawa, T, Sugahara, K, Ogasawara
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On the Specificity of Kainic Acid

Science, 1979
The specificity of the neurotoxic agent, kainic acid, for destroying cell bodies while sparing terminals and fibers of passage was examined by infusing this agent into the axons of the dorsal noradrenergic bundle and measuring the degree of depletion of noradrenaline concentrations and the reduction in noradrenaline uptake in cortex and hippocampus ...
S T, Mason, H C, Fibiger
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Kainic acid derivatives with anticonvulsant activity

Neuroscience Letters, 1984
beta-Kainic acid, and the glycine and amino-methylphosphonate derivatives of alpha- and beta-kainic acid, have been injected intracerebroventricularly in DBA/2 mice, that show sound-induced seizure responses. An anticonvulsant effect is observed with marked protection against the tonic and clonic phases of the seizure response.
J F, Collins, A J, Dixon, G, Badman, G, De Sarro, A G, Chapman, G P, Hart, B S, Meldrum   +6 more
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The mechanism of kainic acid neurotoxicity

Nature, 1983
The putative excitatory transmitters glutamate and aspartate, as well as their excitatory analogues, can kill neurones in the central nervous system and may thus be involved in the pathogenesis of various neurodegenerative disorders. Several studies have suggested that postsynaptic receptors are important in the mechanism of toxicity.
J, Garthwaite, G, Garthwaite
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Ethanol, baclofen, and kainic acid neurotoxicity

Experimental Neurology, 1980
Abstract The neurotoxicity induced by intrastriatal injections of kainic acid was greater in rats drinking approximately 4 ml ethanol per day for 16 days before injection than in controls. Intraperitoneal injection of 5 mg/kg baclofen (parachlorophenyl GABA), 30 min before the kainic acid injections had a slight protective action.
E G, McGeer, A, Jakubovic, E A, Singh
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Neuroexcitatory amino acids: phosphonic analogue of kainic acid

Amino Acids, 1992
The enantioselective synthesis of phosphonic analogue of kainic acid is described.
M, Tabcheh, L, Pappalardo, M L, Roumestant, P, Viallefont   +3 more
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Intrahippocampal kainic acid reduces glutamine synthetase

Neuroscience, 1990
Kainic acid was injected into the hippocampus of rats and glutamine synthetase was measured to determine whether astrocytes are involved in the early effects of this neurotoxic agent. Glutamine synthetase was reduced by 38%, 24 h after the stereotaxic application of 4 nmol of kainic acid to this region.
R A, Waniewski, D, McFarland
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Kainic acid‐induced limbic seizures

Neurology, 1981
Surface and depth electroencephalograms (EEGs) were studied after intravenous injections of kainic acid (KA). High frequency oscillations and spikes appeared in the hippocampus at a dose (1 mg per kilogram) that did not affect other structures. Higher doses (greater than or equal to 4 mg per kilogram) led to electrical seizures in limbic structures ...
E W, Lothman, R C, Collins, J A, Ferrendelli   +2 more
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Kainic acid and 1′‐hydroxykainic acid from palmariales

Natural Toxins, 1994
AbstractThe distribution of kainic acid among various red algae was investigated. Analysis of free amino acids from different populations of Palmaria palmata showed that some were unable to accumulate kainic acid to detectable concentrations, whereas in two dwarf mutants it was a major component of the free amino acid composition.
U P, Ramsey, C J, Bird, P F, Shacklock, M V, Laycock, J L, Wright   +4 more
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Kainic acid: Neurophysiological and neurotoxic actions

Life Sciences, 1979
Abstract Kainic acid, an anthelmintic drug structurally related to glutamate, has excitatory electrophysiological actions on neurons in the vertebrate CNS and at the invertebrate neuromuscular junction. Recently, it has been shown to destroy neuronal cell bodies and dendrites in several regions of the vertebrate CNS, while sparing afferent fibers and
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