Results 171 to 180 of about 15,680 (217)

Microinjection of kainic acid into the rat hippocampus

European Journal of Pharmacology, 1978
The effects of unilateral injection of kainic acid into the rate hippocampus have been examined in terms of morphologic, neurochemical and behavioral sequelae. Infusion of 10 nmoles if kainate causes a rapid and complete degeneration of neuronal perikarya in the entire hippocampal formation followed by gliosis and atrophy of the region. This unilateral
R, Schwarcz, R, Zaczek, J T, Coyle
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Distribution and persistence of kainic acid in brain

Life Sciences, 1979
The distribution of 3H-kainic acid in rat brain was studied as a function of time after injections of 5 nmoles into the neostriatum, substantia nigra or cerebellum. More than half of the injected material had disappeared from the injection site and the brain by 1/2 hour post injection.
U, Scherer-Singler, E G, McGeer
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The control of kainic acid-induced status epilepticus

Epilepsy Research, 2010
In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is ...
Vermoesen, Katia, Clinckers, Ralph, Massie, Ann, Michotte, Yvette, Smolders, Ilse Julia   +4 more
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Lipid peroxidation in hippocampus early and late after status epilepticus induced by pilocarpine or kainic acid in Wistar rats

Neuroscience Letters, 2000
Oxidative stress has been implicated in a variety of acute and chronic neurologic conditions, including epilepsy. Both the kainic acid and pilocarpine are useful models of temporal lobe epilepsy in rodents.
Felipe Dal-Pizzol, Mónica R M Vianna, João Quevedo   +2 more
exaly   +1 more source

Neuroexcitatory amino acids: phosphonic analogue of kainic acid

Amino Acids, 1992
The enantioselective synthesis of phosphonic analogue of kainic acid is described.
M, Tabcheh, L, Pappalardo, M L, Roumestant, P, Viallefont   +3 more
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Kainic acid and 1′‐hydroxykainic acid from palmariales

Natural Toxins, 1994
AbstractThe distribution of kainic acid among various red algae was investigated. Analysis of free amino acids from different populations of Palmaria palmata showed that some were unable to accumulate kainic acid to detectable concentrations, whereas in two dwarf mutants it was a major component of the free amino acid composition.
U P, Ramsey, C J, Bird, P F, Shacklock, M V, Laycock, J L, Wright   +4 more
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The activation of glutamate receptors by kainic acid and domoic acid

Natural Toxins, 1998
The neurotoxins kainic acid and domoic acid are potent agonists at the kainate and alphaamino-5-methyl-3-hydroxyisoxazolone-4-propionate (AMPA) subclasses of ionotropic glutamate receptors. Although it is well established that AMPA receptors mediate fast excitatory synaptic transmission at most excitatory synapses in the central nervous system, the ...
D R, Hampson, J L, Manalo
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[Kainic acid and neurobiology].

Ceskoslovenska fysiologie, 2007
Kainic acid, the analog of excitatory amino acid L-glutamate, interacts with specific receptors in the central nervous system. During last 25 years it has become a tool for studying many human brain disorders, for example human temporal lobe epilepsy, Huntington's chorea etc.
Vladimír, Riljak, Katerina, Jandová, Milos, Langmeier   +2 more
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Kainic acid: Neurophysiological and neurotoxic actions

Life Sciences, 1979
Abstract Kainic acid, an anthelmintic drug structurally related to glutamate, has excitatory electrophysiological actions on neurons in the vertebrate CNS and at the invertebrate neuromuscular junction. Recently, it has been shown to destroy neuronal cell bodies and dendrites in several regions of the vertebrate CNS, while sparing afferent fibers and
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Structure of Kainic Acid and its Isomer, Allokainic Acid

Nature, 1958
IN 1953, Murakami, Takemoto and their collaborators1 isolated the most active component of Digenea simplex Agardh which has been well known as an anthelmintic (vermifuge) for more than a thousand years. They named it kainic acid after ‘Kaininso’, the Japanese name of the mother alga. Kainic acid, C10H15O4N, has an intense anthelmintic effect, about ten
I, NITTA, H, WATASE, Y, TOMIIE
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