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[Kainic acid and neurobiology].
Ceskoslovenska fysiologie, 2007Kainic acid, the analog of excitatory amino acid L-glutamate, interacts with specific receptors in the central nervous system. During last 25 years it has become a tool for studying many human brain disorders, for example human temporal lobe epilepsy, Huntington's chorea etc.
Vladimír, Riljak +2 more
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Model Studies Towards Kainic Acid
Synlett, 2002A novel photochemical approach to the kainoid ring system is presented alongside model studies to demonstrate its feasibility.
E. S. Greenwood, P. J. Parsons
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Synaptic localization of kainic acid binding sites
Nature, 1981The heterocyclic compound kainic acid (KA) is a potent excitant when applied to mammalian neurones. Lesions caused by injections of KA into the rat striatum and hippocampus cause similar patterns of damage to those seen in Huntington's chorea and status epilepticus, respectively.
A C, Foster +3 more
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Kainic-acid-induced seizures: A developmental study
Developmental Brain Research, 1984Developmental dose-response curves for kainic-acid-induced seizures were generated in rats. Rats at 15-18 days (pups), 33-37 days ( pubescents ) and over 90 days (adults) were administered kainic acid intraperitoneally. Seizures were elicited in all 3 age groups, but some of the behavioral manifestations differed in the pups.
B J, Albala, S L, Moshé, R, Okada
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Limbic Seizures Induced by Systemically Applied Kainic Acid: How Much Kainic Acid Reaches the Brain?
1986Systemic or intracerebral injection of the neurotoxin kainic acid (KA) in rats induces a limbic seizure and brain damage syndrome, which has been proposed as an experimental animal model for human temporal lobe epilepsy (Nadler, 1981; Ben-Ari, 1985). The electrographic, neurochemical, metabolic and histopathological consequences involve preferentially ...
M L, Berger +3 more
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Kainic Acid Induces Sprouting of Retinal Neurons
Science, 1984The neurotoxin kainic acid caused dose-dependent morphological changes in horizontal cells of the retinas of adult cats and rabbits. High concentrations of kainic acid killed the cells, but when exposed to sublethal doses they contracted their dendritic fields and sent sprouting processes into the inner retina.
L, Peichl, J, Bolz
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Enantioselective Total Synthesis of (−)-α-Kainic Acid
Organic Letters, 2010An enantioselective total synthesis of (-)-alpha-kainic acid is described. Key steps are an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselective intramolecular Pauson-Khand reaction. Subsequent steps involve a Baeyer-Villiger reaction, reduction of the resulting lactone, and direct Jones oxidation of a ...
Andreas, Farwick, Günter, Helmchen
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Levetiracetam protects against kainic acid-induced toxicity
Life Sciences, 2004We investigated the Levetiracetam (LVT) ability to protect the brain against kainic acid (KA) induced neurotoxicity. Brain injury was induced by intraperitoneal administration of KA (10 mg/kg). Sham brain injury rats were used as controls. Animals were randomized to receive either LVT (50 mg/kg) or its vehicle (1 ml/kg) 30 min. before KA administration.
MARINI, Herbert Ryan +12 more
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Neuronal mapping with kainic acid
Trends in Neurosciences, 1978Abstract Kainic acid, found naturally-occurring in sea-weed, is a substance which is structurally-related to the putative neurotransmitter, glutamate. Kainic acid has now entered the neuroscientists armoury of equipment as a potent and selective neurotoxin which will cause the fast degeneration of neurones with cell bodies in the area of injection ...
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