Results 11 to 20 of about 15,680 (217)
β-Kainic acid is not an amino acid antagonist
Journal of Pharmacy and Pharmacology, 1985 Abstract β-Kainic acid has been reported to have anticonvulsant properties. In view of its structural relationship to α-kainic acid it has therefore been tested for antagonist activity at excitatory receptors for N-methylaspartate, quisqualate and α-kainate using anaesthetized rats and brain slice preparations.
T W, Stone, J F, Collins
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The role of rosemary extract in degeneration of hippocampal neurons induced by kainic acid in the rat: A behavioral and histochemical approach [PDF]
Journal of Integrative Neuroscience, 2018 Systemic kainic acid administration has been used to induce experimental temporal lobe epilepsy in rats. The aim was to evaluate the neuroprotective effect of rosemary extract (40% Carnosic acid) against kainic acid-induced neurotoxicity in hippocampus ...
Elahe Naderali, Farnaz Nikbakht, Sattar Norouzi Ofogh, Homa Rasoolijazi
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Excitatory amino acids, possible causative agents of nodding syndrome in eastern Africa
Tropical Medicine and Health, 2023 Background Nodding syndrome (NS) is one type of epilepsy and a progressive disease characterized by nodding symptoms with children in sub-Saharan Africa.
Yasushi Miyauchi +4 more
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A Practical Synthesis of (−)-Kainic Acid [PDF]
Organic Letters, 2011 A highly practical stereoselective total synthesis of (-)-kainic acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid by hydrolysis of a nitrile accompanied by epimerizaion.
Satoshi, Takita +2 more
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Examining the role of astrogliosis and JNK signaling in post-traumatic epilepsy
Egyptian Journal of Neurosurgery, 2022 Objective Post-traumatic epilepsy is a devastating complication of traumatic brain injury that has no targeted pharmacological therapy. Previous literature has explored the role of the c-Jun N-terminal kinase (JNK) pathway in epilepsy and the creation of
Coulter Small +4 more
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Bangladesh Journal of Pharmacology, 2023 This study aims to evaluate the anticonvulsant effect of the aqueous extract of Rhus pentaphylla and Cuminum cyminum (300 mg/kg), orally, 45 min before intrahippocampal injection of kainic acid (1 µg/µL).
Khadija Oubella +3 more
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Laboratory Animal Research, 2020 The kainic acid-induced seizure mouse model is widely used in epilepsy research. In this study, we applied kainic acid to the subcutaneous injections of three different sources of DBA/2 mice to compare and evaluate the seizure response.
Kyung-Ku Kang +10 more
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DNA methylation mediates persistent epileptiform activity in vitro and in vivo. [PDF]
PLoS ONE, 2013 Epilepsy is a chronic brain disorder involving recurring seizures often precipitated by an earlier neuronal insult. The mechanisms that link the transient neuronal insult to the lasting state of epilepsy are unknown.
Ziv M Machnes +11 more
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Kainic Acid and MPP+ Induce Upregulation of GLT-1 in Neuroblastoma and Glia Cells
Bezmiâlem Science, 2021 Objective:Glutamate is the major excitatory transmitter in the brain. The excessive glutamate will lead to excitotoxicity. Glutamate transporter-1 (GLT-1) is the major transporter that performs 95% of the glutamate clearance contributing to normal ...
Rabia UYARICI +2 more
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Effect of Hydroalcoholic Extract of Rosa damascena on Hippocampal Tissue Changes in Temporal Lobe Epilepsy in Rats [PDF]
مجله دانشگاه علوم پزشکی گرگان, 2023 Background and Objective: Temporal lobe epilepsy is characterized by the degeneration of hippocampal neurons and the sprouting of mossy fibers in the dentate area. This study aimed to investigate the impact of the hydroalcoholic extract of Rosa damascene
Reyhanesadat Hashemi-Golpayegani +3 more
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