Results 31 to 40 of about 15,680 (217)
Aminooxadiazolyl kainic acid reveals that kainic acid receptors contribute to astrocytoma glutamate signaling [PDF]
, 2021 ABSTRACT The excitatory neurotransmitter glutamate triggers a Ca 2+ rise and the extension of processes in astrocytes. Our results suggest that kainic acid receptors (KAR) can independently initiate glutamate signaling in astrocytoma U118-MG cells.
Mitra Sadat Tabatabaee +3 more
openaire +1 more source
Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits. [PDF]
PLoS ONE, 2014 Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life.
Gisela H Maia +6 more
doaj +1 more source
Photostability of Kainic Acid in Seawater
, 2016 The environmental degradation of a mixture of domoic acid (DA) and kainic acid (KA) in seawater with and without added transition metals is reported. The association constants for kainic acid with FeIII and CuII were determined using 1H nuclear magnetic ...
Justina M. Burns (2204383) +4 more
core +1 more source
Elucidating the dopaminergic neurotoxicity of kainic acid [PDF]
, 2020 Dopamine is an essential catecholamine neurotransmitter in the central and peripheral nervous system. This monoaminergic neurotransmitters is required for the maintenance of several physiological functions (control of movement, mental functions (mood ...
Alghenaim, Fada
core
Frontiers in Neuroscience, 2018 Axon degeneration has been implicated as a pathological process in several neurodegenerative diseases and acquired forms of neural injury. We have previously shown that stabilizing microtubules can protect axons against excitotoxin-induced fragmentation,
Kelsey Hanson +3 more
doaj +1 more source
Epithelium-dependent effect of L-glutamate on airways: involvement of prostaglandins
Mediators of Inflammation, 2002 We investigated the effect of the excitatory amino acid (EAA) receptor agonists L-glutamate, N-methyl-D-aspartate (NMDA), (RS)-a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainic acid on KCl-induced contractions of rabbit tracheal ...
Apostolia A. Hatziefthimiou +2 more
doaj +1 more source
MicroRNA-Mediated Downregulation of the Potassium Channel Kv4.2 Contributes to Seizure Onset
Cell Reports, 2016 Seizures are bursts of excessive synchronized neuronal activity, suggesting that mechanisms controlling brain excitability are compromised. The voltage-gated potassium channel Kv4.2, a major mediator of hyperpolarizing A-type currents in the brain, is a ...
Christina Gross +13 more
doaj +1 more source
Annals of Neurology, EarlyView.Objective Drug‐resistant epilepsy (DRE) remains a clinical challenge, as therapies modifying disease trajectory are lacking. Increasing evidence implicates gut microbiota dysbiosis in epilepsy pathophysiology, with short‐chain fatty acids (SCFAs) emerging as key microbial metabolites with neuroprotective and anti‐inflammatory properties.
Akash A. Bera +16 more
wiley +1 more source
Short Total Synthesis of (−)-Kainic Acid
, 2016 A short total synthesis of (−)-kainic acid has been developed involving a novel diastereofacial differentiating Cu-catalyzed Michael addition–cyclization reaction, which provided access to a chiral pyrroline in a highly stereoselective manner. The chiral
Tetsuro Shinada (1267575) +2 more
core +1 more source
Epilepsia, EarlyView.Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier +82 more
wiley +1 more source