Results 21 to 30 of about 15,680 (217)
Archives of Epilepsy, 2022 Objective: Aquaporin4 is the main water channel in the brain that is associated with neurological disorders. The role and the expressive changes of aquaporin4 in epilepsy are still limited and controversial. The study aims to evaluate the expression of c-
Emine Taşkıran +7 more
doaj +1 more source
Glutamic acid-insensitive [3H]kainic acid binding in goldfish brain [PDF]
, 1992 Kainic acid is supposed to be a specific agonist for a subclass of excitatory glutamate receptors in the vertebrate CNS. An investigation of (2 nM) [3H]kainic acid binding sites in goldfish brain, using quantitative autoradiography, has revealed evidence
Wilmot, George R. +2 more
core +1 more source
Systemic injection of kainic acid differently affects LTP magnitude depending on its epileptogenic efficiency. [PDF]
PLoS ONE, 2012 Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures and to potentially affect synaptic plasticity, it can also produce physiological-like oscillations and trigger some forms of long ...
Luz M Suárez +7 more
doaj +1 more source
Membranes, 2021 Morphologically and functionally identical to brain synapses, the nerve ending particles synaptosomes are biochemically derived membrane structures responsible for the transmission of neural information.
Virjinia Doltchinkova +2 more
doaj +1 more source
Modulation of kainic acid neurotoxicity in rats [PDF]
, 1994 1. Systemically administered kainic acid causes a dose dependent increase in the amount of peripheral benzodiazepine receptor in the rat hippocampus, as assessed by [3H]PK11195 binding. 2. This increase in binding is due to an increase in Bmax and not K0.
MacGregor, Duncan Gregor
core +1 more source
A Practical Synthesis of (−)-Kainic Acid
, 2016 A highly practical stereoselective total synthesis of (−)-kainic acid is described. This synthesis features the stereoselective alkylation of an iodolactone intermediate that was efficiently prepared from (+)-carvone and introduction of carboxylic acid ...
Satoshi Takita (2209201) +2 more
core +2 more sources
Biotechnology & Biotechnological Equipment, 2017 Epilepsy is one of most reported neurological disorders after migraine, stroke and Alzheimer's disease. Empiric clinical data reveal that seizures and epilepsy more likely affect men than women.
Slavina Surcheva +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Objective: Our study aimed to explore whether gasdermin D (GSDMD)-mediated pyroptosis is involved in the mechanism of kainic acid-induced seizures.Methods: C57BL/6 mice were randomly divided into sham and epilepsy groups.
Lu Xia +8 more
doaj +1 more source
Polarization anatomy of a kainic acid seizure [PDF]
Psychiatry and Clinical Neurosciences, 1997 Abstract Slow voltage‐sensitive dyes work by accumulating in brain tissue and report the average membrane potential of neurons and glia. The voltage‐sensitive dye diO‐C2‐5 was used to monitor the polarization state of 27 brain structures in the rat during a systemically induced, behaviorally mild, kainic acid seizure using a 20 s recording period.
R M, Dasheiff, D S, Sacks
openaire +2 more sources
BMC Research Notes, 2017 Background Antiaris toxicaria has previously shown anticonvulsant activity in acute animal models of epilepsy. The aqueous extract (AAE) was further investigated for activity in kindling with pentylenetetrazole and administration of pilocarpine and ...
Priscilla Kolibea Mante +2 more
doaj +1 more source