Results 51 to 60 of about 15,680 (217)
Journal of Lipid Research, 2017 Excitotoxicity is the pivotal mechanism of neuronal death. Prostaglandins (PGs) produced during excitotoxicity play important roles in neurodegenerative conditions.
Kensuke Iwasa +4 more
doaj +1 more source
Absence seizures: Update on signaling mechanisms and networks
Epilepsia Open, EarlyView.Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley +1 more source
Tandem Wittig−Ene Reaction Approach to Kainic Acid
, 2016 The first example of a tandem Wittig−intramolecular ene reaction approach and its application toward the synthesis of kainic acid is reported. The synthetic pathway involves conversion of prenyl bromide into phosphorane 3, followed by one-pot Wittig ...
Santosh G. Tilve (556388) +2 more
core +1 more source
Frontiers in Neuroscience, 2016 We report the methodology for the chronic delivery of an excitotoxin to the mouse spinal cord via surgically implanted osmotic mini-pumps. Previous studies have investigated the effect of chronic application of excitotoxins in the rat, however there has ...
Catherine A Blizzard +2 more
doaj +1 more source
Differential conserted activity induced regulation of Nogo receptors (1-3), LOTUS and Nogo mRNA in mouse brain. [PDF]
PLoS ONE, 2013 Nogo Receptor 1 (NgR1) mRNA is downregulated in hippocampal and cortical regions by increased neuronal activity such as a kainic acid challenge or by exposing rats to running wheels.
Tobias E Karlsson +4 more
doaj +1 more source
Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges
Epilepsia Open, EarlyView.Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus +7 more
wiley +1 more source
High-Pressure Diels−Alder Approach to Natural Kainic Acid
, 2006 International audienceThe first Diels-Alder based synthesis of (-)-kainic acid is described. Danishefsky's diene and a vinylogous malonate derived from 4-hydroxyproline combine under high pressure to afford a key bicyclic intermediate with virtually no ...
Orellana, Arturo +3 more
core +1 more source
, 2021 Background: Overactivation of P/Q type of calcium channels leads to neurological disorders. The venom of Agelena labyrinthica consists of substances which can inhibit this channel. One of the most important compounds is agatoxin.
Hosseini-Sharifabad, A. +3 more
core +1 more source
Bruce/apollon promotes hippocampal neuron survival and is downregulated by kainic acid
, 2005 Prolonged or excess stimulation of excitatory amino acid receptors leads to seizures and the induction of excitotoxic nerve cell injury. Kainic acid acting on glutamate receptors produces degeneration of vulnerable neurons in parts of the hippocampus and
Korhonen, Laura, +5 more
core +2 more sources
Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice
Scientific Reports, 2021 MicroRNAs are short non-coding RNAs that negatively regulate protein levels and perform important roles in establishing and maintaining neuronal network function.
Aoife Campbell +9 more
doaj +1 more source