Results 71 to 80 of about 15,680 (217)

Do Fits Really Beget Fits? The Effect of Previous Epileptic Activity on the Subsequent Induction of the Tetanus Toxin Model of Limbic Epilepsy in the Rat

Neurobiology of Disease, 2001
The effect of pretreatment with either tetanus toxin (in ventral hippocampus) or kainic acid (into dorsal hippocampus, with or without suppression of seizures by phenobarbital) on the subsequent development of epilepsy in rats injected with tetanus toxin
J. Mellanby, A.J. Milward
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Prosaposin overexpression following kainic acid-induced neurotoxicity.

PLoS ONE, 2014
Because excessive glutamate release is believed to play a pivotal role in numerous neuropathological disorders, such as ischemia or seizure, we aimed to investigate whether intrinsic prosaposin (PS), a neuroprotective factor when supplied exogenously in ...
Hiroaki Nabeka, Keigo Uematsu, Hiroko Takechi, Tetsuya Shimokawa, Kimiko Yamamiya, Cheng Li, Takuya Doihara, Shouichiro Saito, Naoto Kobayashi, Seiji Matsuda   +9 more
doaj   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

Total Synthesis of (−)-α-Kainic Acid by (−)-Sparteine-Mediated Asymmetric Deprotonation−Cycloalkylation^†

, 2016
We report a new enantioselective synthesis of (−)-α-kainic acid from d-serine methyl ester hydrochloride, based on a (−)-sparteine-mediated asymmetric deprotonation of an intermediate carbamate that, by stereospecific anti SN‘SE‘ intramolecular ...
Dieter Hoppe (2274349), M. Montserrat Martinez (2705458)   +1 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Calmidazolium (CMZ) differentially bocks NMDA-, and kainic acid (KA)-induced pain-responses.

, 2013
NMDA and kainic acid were iontophoresed, sequentially, 2 min apart using −85 nA and −30 nA, respectively, then calmidazolium was ejected as shown, which markedly inhibited the initial pain signals at the levels of dorsal horn neurons.
Katalin Jósvay (31409), László Pecze (31410), Ferenc Ötvös (31414), Csaba Vizler (31416), Dénes Budai (31413), Zoltán Oláh (31408), Tamás Letoha (31411), Norbert Babai (31412), Sándor Szalma (31415)   +8 more
core   +1 more source

1 Hz Low‐Frequency Repetitive Transcranial Magnetic Stimulation Ameliorates Epilepsy by Suppressing Interferon‐γ Signaling‐Dependent Microglial Synaptic Phagocytosis in Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
In a mouse model of recurrent seizures, 1 Hz rTMS exerted neuroprotective effects by enhancing IFN‐γ‐dependent STAT2 activation in microglia and reducing CADM1/2/3 expression, thereby limiting excessive synaptic phagocytosis. Notably, co‐treatment with a neutralizing antibody against IFN‐γ abolished the 1 Hz rTMS‐induced STAT2 activation and the ...
Donghui Lin, Duan Wang, Nong Xiao
wiley   +1 more source

Immunomorphologic assessment of changes in functional astroglial proteins in a kainate-induced hippocampal sclerosis model [PDF]

Анналы клинической и экспериментальной неврологии
Introduction. Astrocytes are involved in mediator metabolism, neuroplasticity, energy support of neurons and neuroinflammation, and this determines their pathogenetic role in epilepsy. Aim. This study aimed at evaluating region-specific changes in the
Dmitry N. Voronkov, Anna V. Egorova, Evgenia N. Fedorova, Alla V. Stavrovskaya, Ivan A. Potapov, Anastasiya K. Pavlova, Vladimir S. Sukhorukov   +6 more
doaj   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, Volume 11, Issue 3, Page 1036-1045, June 2026.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source