Results 81 to 90 of about 15,680 (217)

Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed, Yilin Wang, Yangping Li, Guoku Hu, Jingjing Yang, Bing Yao, Andrew Escayg   +6 more
wiley   +1 more source

Kainic Acid and Nitrergic Neurons Kainic Acid and Nitrergic Neurons in Immature Hippocampus

, 2020
Jandová K.; Riljak V.; Pokorný J.; Langmeier M. Abstract: Using histochemical analysis the effect of intraperitoneal administration of kainic acid on hippocampal neurons was studied. 18-day-old male rats of the Wistar strain received kainic acid (10mg/kg)
MD Kateřina Jandová, Riljak V, Jandová K, Langmeier M, Pokorný J   +4 more
core  

The Effect of Alpha-Lipoic Acid on Learning and Memory Deficit in a Rat Model of Temporal Lobe Epilepsy

Basic and Clinical Neuroscience, 2012
Introduction: Epilepsy is a chronic neurological disorder in which patients experience spontaneous recurrent seizures and deficiency in learning and memory.
Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Mitra Kamran, Narges Karimi   +3 more
doaj   +2 more sources

Neuronal protective effect of Songling Xuemaikang capsules alone and in combination with carbamazepine on epilepsy in kainic acid-kindled rats

Pharmaceutical Biology, 2019
Context: Epilepsy is a common life-threatening neurological disorder that is often drug-resistant and associated with cognitive impairment. The traditional Chinese patent medicine Songling Xuemaikang capsules (SXC) is clinically used for epilepsy therapy
Haiyan Yang, Rui Zhang, Chen Jia, Mengyu Chen, Wen Yin, Liming Wei, Haisheng Jiao   +6 more
doaj   +1 more source

Differential roles of cyclooxygenase isoforms after kainic acid-induced prostaglandin E2 production and neurodegeneration in cortical and hippocampal cell cultures

, 2001
Prostaglandins, which are cyclooxygenase (COX) products, are pathologically up-regulated, and have been proven to be closely associated with neuronal death.
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core   +1 more source

The effects of glycemic control on seizures and seizure-induced excitotoxic cell death

BMC Neuroscience, 2012
Background Epilepsy is the most common neurological disorder after stroke, affecting more than 50 million persons worldwide. Metabolic disturbances are often associated with epileptic seizures, but the pathogenesis of this relationship is poorly ...
Schauwecker Paula
doaj   +1 more source

Enantioselective Total Synthesis of (−)-α-Kainic Acid

, 2016
An enantioselective total synthesis of (−)-α-kainic acid is described. Key steps are an Ir-catalyzed allylic amination with a propargylic amine to provide an enyne and a diastereoselective intramolecular Pauson−Khand reaction.
Günter Helmchen (1852765), Andreas Farwick (2250016)   +1 more
core   +1 more source

The Effect of long-term rapamycin administration on intracellular calcium quantification and RhoA activity in kainic acid epilepsy model [PDF]

Brazilian Journal of Pharmaceutical Sciences
Epilepsy affects around 50 million people worldwide, with 30% of them being refractory epilepsy. This shows that there is still a need for novel anti-seizure medication that have different mechanisms.
Machlusil Husna, Kusworini Handono, Hidayat Sujuti, Aulanni’am Aulanni’am, Rumman Karimah, Afiyfah Kiysa Waafi, Alya Satira   +6 more
doaj   +1 more source

In vivo measurement of hippocampal GABAA/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy.

PLoS ONE, 2014
PurposeImbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE). This study aimed to investigate whether [(18)F]-flumazenil ([(18)F]-FMZ) PET could be used to non-invasively ...
Lucy Vivash, Marie-Claude Gregoire, Viviane Bouilleret, Alexis Berard, Catriona Wimberley, David Binns, Peter Roselt, Andrew Katsifis, Damian E Myers, Rodney J Hicks, Terence J O'Brien, Stefanie Dedeurwaerdere   +11 more
doaj   +1 more source

Hippocampal sclerosis and upregulation of inflammatory markers in the hippocampus of kainic acid-treated rats.

, 2013
A. Haematoxylin-eosin staining showing typical hippocampal sclerosis in kainic acid-treated rats (KA) (left) as compared to controls (right). Bar represents 200 µm. B. Comparison of the intensity of the GFAP astrocytic marker staining in kainic acid- and
Abdelwahed Chtarto (290728), Catherine Pythoud (290734), Ralph Clinkers (290737), Liliane Tenenbaum (290738), Marc Levivier (290735), Elias Gebara (290730), Katia Vermoesen (290731), Catherine Melas (290733), Ruth Luthi-Carter (18698), Olivier De Witte (290736), Olivier Bockstael (290729)   +10 more
core   +1 more source