Results 91 to 100 of about 15,680 (217)

Kainic acid-induced eye enlargement in chickens: differential effects on anterior and posterior segments [PDF]

, 1988
Intravitreal injections of kainic acid were used to examine the significance of normal retinal activity for eye growth in chickens, this acid being chosen because of its known, selective neurotoxic effects on cells in the chicken retina.
Wildsoet, C. F., Pettigrew, J. D.
core  

Stereocontrolled Total Synthesis of (−)-Kainic Acid

, 2016
A stereocontrolled total synthesis of (−)-kainic acid is described. A fully functionalized trisubstituted pyrrolidine ring was constructed by ring-closing metathesis of an acrylate derivative followed by an intramolecular Michael addition of the ...
Hiroshi Sakaguchi (2249122), Tohru Fukuyama (1508317), Hidetoshi Tokuyama (1748674)   +2 more
core   +1 more source

Outer hair cells stir cochlear fluids

eLife
We hypothesized that active outer hair cells drive cochlear fluid circulation. The hypothesis was tested by delivering the neurotoxin, kainic acid, to the intact round window of young gerbil cochleae while monitoring auditory responses in the cochlear ...
Choongheon Lee, Mohammad Shokrian, Kenneth S Henry, Laurel H Carney, J Christopher Holt, Jong-Hoon Nam   +5 more
doaj   +1 more source

Autoradiographic analysis of [3H]kainic acid binding in primate brain.

, 1987
The distribution of [3H]kainic acid binding sites was studied in the primate brain using semiquantitative autoradiography. The highest levels of binding were observed in the hippocampal area CA3 and the dentate gyrus.
Crossman, AA.R., Slater, P, Cross, A, Mitchell, I, Skan, W   +4 more
core   +1 more source

The effect of intrahippocampal injection of kainic acid on corticosterone release in rats

, 1990
The aim of the present study was to investigate whether the hippocampus exerts a modulatory effect on the activity of the hypothalamic-pituitary-adrenal (HPA) axis.
Taljaard J.J.F., Daniels W.M.U., Russell V.A., Engelbrecht A.H., Jaffer A.   +4 more
core   +1 more source

Synthetic Studies Toward Kainic acid and Lycorane

, 2007
We have developed an one-pot reaction procedure to polysubstituted pyroglutamates with three contiguous chiral centers.
Liu, Yen-ting
core  

Stereocontrolled Synthesis of 4-Substituted (±)-Kainic Acids

, 2016
Racemic 4-substituted kainic acids 4a,b have been synthesized from ethyl (1SR,2SR,5RS,6RS)-N-(benzyloxycarbonyl)-3-aza-6-hydroxy-6-methylbicyclo[3.3.0]octane-2-carboxylate (7) after its transformation in the pyroglutamate derivative 6.
Jesús Ezquerra (3024915), Almudena Rubio (3015786), Iván Collado (2674261), Ana I. Mateo (3024924)   +3 more
core   +1 more source

Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus

, 2013
The neuroprotective role of 17β-estradiol in the hippocampal dentate gyrus of adult rats treated with kainic acid has been investigated. The systemic injection of a single low dose (7 mg/kg) of kainic acid to ovariectomized rats produced a marked loss of
Azcoitia, I., García-Segura, Luis M., Sierra, Amanda   +2 more
core   +1 more source

Syntheses of aza analogues of kainic acid

, 2008
The kainate receptors are one of the three major groups of ionotropic glutamate receptors in the mammalian central nervous system. They are so named after their most potent agonist, kainic acid (KA), a natural product isolated from the seaweed Diginea ...
Simovic, Dragan
core  

Kainic acid on the rostral ventrolateral medulla inhibits phrenic output and CO2 sensitivity

, 1988
We used the neurotoxin, kainic acid, which is known to stimulate neuronal cell bodies as opposed to axons of passage by binding to specific amino acid receptors to determine whether cells with such receptors have access to the ventrolateral medullary ...
J. W. Mills, E. E. Nattie, L. C. Ou, W. M. St John   +3 more
core   +1 more source