Results 61 to 70 of about 15,707 (217)

3,4-Methylenedioxymethamphetamine enhances kainic acid convulsive susceptibility [PDF]

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2014
Kainic acid (KA) causes seizures and neuronal loss in the hippocampus. The present study investigated whether a recreational schedule of 3,4-methylenedioxymethamphetamine (MDMA) favours the development of a seizure state in a model of KA-induced epilepsy and potentiates the toxicity profile of KA (20 or 30mg/kg).
Sónia Abad, Fèlix Junyent, Carme Auladell, David Pubill, Mercè Pallàs, Jorge Camarasa, Elena Escubedo, Antonio Camins   +7 more
openaire   +3 more sources

Epilepsy surgery: From bench to the clinics

Epilepsia Open, EarlyView.
Abstract Objective Recent advances in epilepsy surgery in patients with intractable epilepsy make it possible to study the mechanism of epilepsy in human brains. However, the true extent and propagation of each epileptogenic area from the epileptogenic focus in each patient is still difficult to perform “epilepsy cure” by surgery.
Tatsuya Tanaka
wiley   +1 more source

Antagomir-mediated suppression of microRNA-134 reduces kainic acid-induced seizures in immature mice

Scientific Reports, 2021
MicroRNAs are short non-coding RNAs that negatively regulate protein levels and perform important roles in establishing and maintaining neuronal network function.
Aoife Campbell, Gareth Morris, Janosch P. Heller, Elena Langa, Elizabeth Brindley, Jesper Worm, Mads Aaboe Jensen, Meghan T. Miller, David C. Henshall, Cristina R. Reschke   +9 more
doaj   +1 more source

Protective effect of pantothenic acid in kainic acid-induced status eilepticus and associated neurodegeneration in mice [PDF]

, 2022
Souravh Bais, Renu Kumari Rana, Nirmal Dongre, Gaurav Goyanar, Aakash Singh Panwar, Alok Kumar Soni, Shanti Lal Singune   +6 more
openalex   +1 more source

Neonatal seizures and GABAergic drugs: Scylla and Charybdis?

Epilepsia Open, EarlyView.
Abstract Neonates have a high incidence of seizures that are frequently difficult to control with conventional first‐line anti‐seizure medications, which are gamma‐aminobutyric acid (GABA) agonists. The reasons for this clinical problem are multifold but are likely related to the unique physiology of the immature nervous system. Specifically, the early
Kerry W. Thompson, Lucie Suchomelova, Claude G. Wasterlain   +2 more
wiley   +1 more source

Protective effect of Co-enzyme Q10 on seizure, short term spatial memory and oxidative stress in induced-epileptic rats

مجله دانشگاه علوم پزشکی گرگان, 2014
Background and Objective: Temporal lobe epilepsy is the most common type of epilepsy in human. Patients suffer from spontaneous seizures and memory deficiency.
Baluchnejadmojarad T, Roghani M
doaj  

Marine Excitatory Amino Acids: Structure, Properties, Biosynthesis and Recent Approaches to Their Syntheses

Molecules, 2020
This review considers the results of recent studies on marine excitatory amino acids, including kainic acid, domoic acid, dysiherbaine, and neodysiherbaine A, known as potent agonists of one of subtypes of glutamate receptors, the so-called kainate ...
Valentin A. Stonik, Inna V. Stonik
doaj   +1 more source

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome

Epilepsia Open, EarlyView.
Abstract Glut1 deficiency syndrome (Glut1DS) leads to neurological and cognitive symptoms and is primarily treated using carbohydrate‐restricted ketogenic diets. However, a recent clinical trial of a less restrictive, non‐ketogenic, medium chain triglyceride (MCT) diet with a high decanoic acid content suggests efficacy in Glut1DS treatment.
Erwann Pain, Yatra Kapatel, Pankaj K. Singh, Katie Lloyd Jones, Jamuna Selvakumaran, Alberto Malerba, Walter Lucchesi, Tricia Rutherford, Christina A. Gurnett, Matthew C. Walker, Robin S. B. Williams   +10 more
wiley   +1 more source

Proenkephalin Derived Peptides Are Involved in the Modulation of Mitochondrial Respiratory Control During Epileptogenesis

Frontiers in Molecular Neuroscience, 2018
Epilepsies are a group of common neurological diseases exerting a strong burden on patients and society, often lacking clear etiology and effective therapeutical strategies.
Johannes Burtscher, Camilla Bean, Camilla Bean, Luca Zangrandi, Iwona Kmiec, Alexandra Agostinho, Luca Scorrano, Luca Scorrano, Erich Gnaiger, Erich Gnaiger, Christoph Schwarzer   +10 more
doaj   +1 more source

Glycolysis inhibition partially resets epilepsy-induced alterations in the dorsal hippocampus-basolateral amygdala circuit involved in anxiety-like behavior

Scientific Reports, 2023
Pharmacoresistant temporal lobe epilepsy affects millions of people around the world with uncontrolled seizures and comorbidities, like anxiety, being the most problematic aspects calling for novel therapies.
Vahid Ahli Khatibi, Morteza Salimi, Mona Rahdar, Mahmoud Rezaei, Milad Nazari, Samaneh Dehghan, Shima Davoudi, Mohammad Reza Raoufy, Javad Mirnajafi-Zadeh, Mohammad Javan, Narges Hosseinmardi, Gila Behzadi, Mahyar Janahmadi   +12 more
doaj   +1 more source