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Results 131 to 140 of about 31,265 (333)

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng +3 more
wiley +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos +16 more
wiley +1 more source

Kallikrein immobilized on magnetic beads for activity-based assays using mass spectrometry

Frontiers in Analytical Science
A crucial step in drug discovery involves identifying active molecules, which depends on fast and efficient screening assay methods. Kallikreins a family of serine protease enzymes, play a pivotal role in biological fluids and tissues.
Camila Loreta Rocha, Carmen Lúcia Cardoso +1 more
doaj +1 more source

Expression and Distribution of Kallikrein-related Peptidases 5, 7, 8 and 10 in Normal Apocrine Gland of Canine Skin [PDF]

, 2023
Pamela Ehrenfeld +6 more
openalex +1 more source

Human α2‐Macroglobulin: Architecture, Mechanisms, and Functional Implications

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Visual representation of human α2‐macroglobulin in its native and induced conformations. General functions associated with the native form (green), the induced form (white), and both conformations (light red) are indicated. ABSTRACT α2‐Macroglobulin (α2M) is a large glycoprotein and one of the most abundant proteins found in the plasma of vertebrates ...
Pietro de Carvalho Andrade +2 more
wiley +1 more source

A critical appraisal of the intrinsic pancreatic angiotensin-generating system [PDF]

, 2001
The pancreas is a relative newcomer to the stable of tissues with an intrinsic angiotensin-generating system. The involvement of this system in pancreatic activity will be dependent on the angiotensin-generating paths present in the pancreas and their ...
Sernia, Conrad
core

Expression and Androgenic Regulation of Human Prostate‐Specific Kallikreins [PDF]