Results 261 to 270 of about 31,265 (333)

Specificity of potato kallikrein inhibitors for kallikreins

Experientia, 1970
Two polyvalent protease inhibitors, acting especially on plasma kallikrein, were isolated from potatoes. Some of their physicochemical and biological properties were investigated.
H, Moriya, Y, Hojima, C, Moriwaki, T, Tajima   +3 more
openaire   +2 more sources

Human tissue kallikreins: The cancer biomarker family

Cancer Letters, 2007
Miltiadis Paliouras, Eleftherios P Diamandis   +1 more
exaly   +2 more sources

Mesenchymal stem cells differentiate into keratinocytes and express epidermal kallikreins: Towards an in vitro model of human epidermis

Journal of Cellular Biochemistry, 2019
Epidermal differentiation is a complex process in which keratinocytes go through morphological and biochemical changes in approximately 15 to 30 days. Abnormal keratinocyte differentiation is involved in the pathophysiology of several skin diseases.
Jeniffer Farias dos Santos, Nathália Ruder Borçari, Mariana da Silva Araújo, V. A. Nunes   +3 more
semanticscholar   +1 more source

Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.

Journal of Medicinal Chemistry, 2015
The inhibition of kallikreins 5 and 7, and possibly kallikrein 14 and matriptase, (that initiates the kallikrein proteolytic cascade) constitutes an innovative way to treat some skin diseases such as Netherton syndrome.
Xiao Tan, Feryel Soualmia, L. Furio, J. Renard, I. Kempen, L. Qin, M. Pagano, B. Pirotte, C. El Amri, A. Hovnanian, M. Reboud-Ravaux   +10 more
semanticscholar   +1 more source

Cellular distribution of human tissue kallikreins: immunohistochemical localization

Biological Chemistry, 2006
Vassiliki N Karavana, Eleftherios P Diamandis   +1 more
exaly   +2 more sources

Active Kallikrein, Preprokallikrein, and Kallikrein-Inhibitor Complex

1986
Active kallikreins isolated from various exocrine and endocrine tissues were identified by a monoclonal antibody in Western blot analyses to be approximately 38,000 dalton proteins. Kallikreins isolated from rat pancreas, kidney, submandibular gland, brain, spleen and urine were indistinguishable with respect to molecular weight and immunological ...
J, Chao, L, Chao, C M, Woodley, W, Gerald, H S, Margolius   +4 more
openaire   +2 more sources

The Kallikrein-Kinin System

2011
Emerging evidence suggests a role of the kallikrein-kinin system (KKS) in the pathogenesis of diabetic nephropathy (DN). Tissue kallikrein 1 is a member of the tissue kallikrein family that is mainly responsible for the generation of kinins, and bradykinin (BK) is the principal kinin responsible for the biologic actions of the KKS that acts through the
Leung, JCK, Lai, KN, Tang, SCW
openaire   +4 more sources

Kallikrein-related peptidases

Cellular and Molecular Life Sciences, 2008
Kallikrein 1 (KLK1), a key component of the kallikrein-kinin system, originates from a locus on the long arm of chromosome 19 that contains several related serine endopeptidases. The biological role of these kallikrein-related peptidases is not clear, but emerging evidence suggests that they might be important in several physiological systems, e.g., in
A, Lundwall, M, Brattsand
openaire   +2 more sources

Cloning of a kallikrein pseudogene

Clinical Biochemistry, 2004
Kallikreins are a group of serine proteases clustered together on a small region of chromosome 19q13.4. Recent reports suggest that kallikreins are differentially expressed in malignancy and have potential as cancer biomarkers. The human kallikrein gene locus has now been fully characterized and 15 functional kallikreins were identified.
George M, Yousef, Carla A, Borgono, Iacovos P, Michael, Eleftherios P, Diamandis   +3 more
openaire   +2 more sources

Immunological properties of the kallikreins

Biochemical Pharmacology, 1963
Abstract Rabbits immunized with crude or partially purified human urinary and pancreatic kallikreins developed antibodies which inhibited the vasodilator activity of the kallikreins in dogs. The antigenic heterogeneity of the kallikreins was shown by the presence of multiple precipitin bands in agar gel.
M E, WEBSTER, E W, EMMART, W A, TURNER, H, MORIYA, J V, PIERCE   +4 more
openaire   +2 more sources