Results 21 to 30 of about 545,384 (139)

Calcium requirements during mitotic cdc2 kinase activation and cyclin degradation in Xenopus egg extracts. [PDF]

, 1995
Activation of p34cdc2 kinase is essential for entry into mitosis while subsequent deactivation and cyclin degradation are associated with exit. In Xenopus embryos, both of these phases are regulated by post-translational modifications and occur ...
Whitaker, Michael J., Lindsay, Howard D., Ford, Christopher C.   +2 more
core   +4 more sources

Kanamycin biosynthetic gene cluster and proposed kanamycin biosynthetic pathways.

, 2018
(a) Kanamycin biosynthetic gene cluster. (b) Proposed parallel and linear kanamycin biosynthetic pathways.
Zheng Wu (344022), Huanzhang Xia (561060), Xianpu Ni (3491882), Junyang Sun (4285090), Wenli Gao (245749)   +4 more
core   +1 more source

Flavopiridol Protects Against Inflammation by Attenuating Leukocyte-Endothelial Interaction via Inhibition of Cyclin-Dependent Kinase 9 [PDF]

, 2011
Objective: The cyclin-dependent kinase (CDK) inhibitor flavopiridol is currently being tested in clinical trials as anticancer drug. Beyond its cell death–inducing action, we hypothesized that flavopiridol affects inflammatory processes.
Mayer, Bettina A., Nina Berberich, Stefan Zahler, Sass, Gabriele, Fritz Krombach, Vollmar, Angelika M., Tiegs, Gisa, Krombach, Fritz, Fürst, Robert, Robert Fürst, Totzke, Frank, Angelika M. Vollmar, Jos Joore, Gisa Tiegs, Berberich, Nina, Alexander G. Khandoga, Bettina A. Mayer, Joore, Jos, Ulrike K. Schmerwitz, Gabriele Sass, Zahler, Stefan, Frank Totzke, Schmerwitz, Ulrike K., Khandoga, Alexander G.   +23 more
core   +1 more source

Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4 [PDF]

, 2011
Background: cyclin-dependent kinases 2, 4 and 6 (Cdk2, Cdk4, Cdk6) are closely structurally homologous proteins which are classically understood to control the transition from the G1 to the S-phases of the cell cycle by combining with their appropriate ...
Maurer, RI, Jon W Essex, Warenius Hilmar M, Kilburn, Jeremy D., Richard I Maurer, Seabra, LA, Usha Agarwala, Laurence A Seabra, Warenius, Hilmar M., Warenius, HM, Blaydes, JP, Seabra Laurence A, Jeremy D Kilburn, Essex, JW, Agarwala, U, Essex Jon W, Agarwala, Usha, Blaydes Jeremy P, Essex, Jon W., Jeremy P Blaydes, Maurer, Richard I., Agarwala Usha, Seabra, Laurence A., Kilburn Jeremy D, Hilmar M Warenius, Blaydes, Jeremy P., Maurer Richard I, Kilburn, Jeremy D, Kilburn, JD   +28 more
core   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Nitric oxide-induced activation of the AMP-activated protein kinase alpha2 subunit attenuates IKappaB kinase activity and inflammatory responses in endothelial cells [PDF]

, 2011
Background: In endothelial cells, activation of the AMP-activated protein kinase (AMPK) has been linked with anti-inflammatory actions but the events downstream of kinase activation are not well understood.
Timo Frömel, Ingrid Fleming, Beß, Elke, Fißlthaler, Beate, Elke Bess, Fleming, Ingrid, Frömel Timo, Bess Elke, Fisslthaler Beate, Beate Fisslthaler, Frömel, Timo, Fleming Ingrid   +11 more
core   +2 more sources

Hearing modulation affects Alzheimer’s disease progression linked to brain inflammation: a study in mouse models

Molecular Medicine
Background Recent studies have identified hearing loss (HL) as a primary risk factor for Alzheimer’s disease (AD) onset. However, the mechanisms linking HL to AD are not fully understood. This study explored the effects of drug-induced hearing loss (DIHL)
Yoo-Seung Ko, Young-Kyoung Ryu, Sujin Han, Hyung Joon Park, Munyoung Choi, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang, Jihoon Jo, Sungsu Lee, Won-Seok Choi, Hyong-Ho Cho   +11 more
doaj   +1 more source

The Mitogen‐Activated Protein Kinase GhNTF3 Modulates the Arbuscular Mycorrhizal Symbiosis‐Immunity Trade‐Off in Cotton by Regulating Salicylic Acid Biosynthesis

Advanced Science, EarlyView.
AM symbiosis induces GhWAK13 to promote fungal colonization. GhNTF3 negatively regulates symbiosis by promoting SA biosynthesis. GhWAK13 sequesters GhNTF3 at the membrane, limiting its nuclear translocation and relieving SA‐mediated suppression. Under Verticillium stress, GhNTF3 enters the nucleus and interacts with GhJAZ6 to activate SA signaling ...
Shuangjie Jia, Jingshang Wen, Jihang Li, Meina Feng, Yiming He, Ruojun Liu, Qian Liu, Junli Zhang, Kai Cheng, Xiangyu Zhang, Xiao Zhang   +10 more
wiley   +1 more source

Karakteristik Fisikokimia Kit Kering Kanamycin [PDF]

, 2013
KARAKTERISTIK FISIKOKIMIA KIT KERING KANAMYCIN. Kanamycin merupakanantibiotik yang berspektrum luas dan biasa digunakan untuk pengobatan infeksi jika antibiotikyang kurang kuat seperti penisilin tidak dapat diberikan.
Nuraeni, W. (Witri), Nuraeni, Witri, W, T. A. (Teguh), Misyetti, M. (Misyetti), Widyasari, Eva Maria, Widyasari, E. M. (Eva), ., Misyetti, W, Teguh Ambar   +7 more
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source