Results 41 to 50 of about 238,231 (259)

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

Genetic modifiers of Duchenne muscular dystrophy and dilated cardiomyopathy [PDF]

, 2015
OBJECTIVE: Dilated cardiomyopathy (DCM) is a major complication and leading cause of death in Duchenne muscular dystrophy (DMD). DCM onset is variable, suggesting modifier effects of genetic or environmental factors.
Angelini, Corrado, Barp, Andrea, Bello, Luca, Calore, Chiara, Calvo, Vincenzo, Comi, Gp, Ermani, Mario, Gorni, K, Hoffman, Ep, Magri, F, Melacini, Paola, Messina, S, Pantic, Boris, Pegoraro, Elena, Picillo, E, Politano, L, Polo, Angela, Semplicini, Claudio, Soraru', Gianni, Taglia, A, Vianello, Sara, Vita, G, Vita, Gl   +22 more
core   +4 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Comparison of nonparametric estimators versus parametric for reliability function

Ingeniería Investigación y Desarrollo, 2015
One of the main objectives of the area of realiability is to estimate the function of reliability, where traditionally are used non parametric estimators, being more efficient in sample of big sizes.
Javier Ramírez-Montoya
doaj   +1 more source

Comparisons Between the Kaplan-Meier Complement and the Cumulative Incidence for Survival Prediction in the Presence of Competing Events [PDF]

, 2013
Estimating cumulative event probabilities in time-to-event data can be complicated by competing events. Competing events occur when individuals can experience events other than the primary event of interest.
Borrebach, Jeffrey D.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Survival Analysis and its Associated Factors of Beta Thalassemia Major in Hamadan Province

Iranian Journal of Medical Sciences, 2015
Background: There currently is a lack of knowledge about the long-term survival of patients with beta thalassemia (BT), particularly in regions with low incidence of the disease.
Reza Zamani, Salman Khazaei, Shahab Rezaeian   +2 more
doaj  

Estimating the Survival Distribution for Right-Censored Data with Delayed Ascertainment [PDF]

, 2012
In many clinical trials, patients are not followed continuously. This means their vital status may not be immediately recorded. In such cases, the results from the Kaplan-Meier estimator or the log rank test, popular methods used for survival analysis ...
Kim, Eun-Jin
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Association between homocysteine levels and hyperlipidemia prevalence as well as all-cause mortality of hyperlipidemia patients in the US population: results from NHANES database

Frontiers in Cardiovascular Medicine
ObjectiveSeveral studies have investigated the correlation between blood lipids and homocysteine, but no clear conclusions have been defined yet. Therefore, we utilized data from National Health and Nutrition Examination Survey (NHANES) to explore the ...
Jia Wei, Qiang Yang, Xiaofang Wang, Xin He, Wenjing Zhu, Lin Lin, Chang Liu, Canzhan Zhu, Mingjuan Zhang   +8 more
doaj   +1 more source