Results 71 to 80 of about 730,949 (275)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Nonparametric survival analysis of epidemic data

, 2011
This paper develops nonparametric methods for the survival analysis of epidemic data based on contact intervals. The contact interval from person i to person j is the time between the onset of infectiousness in i and infectious contact from i to j, where
Aalen, Aalen, Altshuler, Becker, Becker, Carcione, Cauchemez, Cox, Dempster, Donnelly, Ferguson, Ferguson, Fine, France, Fraser, Kalbfleisch, Kaplan, Kenah, Kenah, Lee, Lipsitch, McBryde, Mills, Morgan, Müller, Nelson, Rampey, Rhodes, Roberts, Sinha, Sugimoto, Svensson, Van der Vaart, Wallinga, Wallinga, Watts, Wegman, White, Yang   +38 more
core   +1 more source

Determination of the most appropriate method for extrapolating overall survival data from a placebo-controlled clinical trial of lenvatinib for progressive, radioiodine-refractory differentiated thyroid cancer [PDF]

, 2016
Background: Cost-effectiveness models for the treatment of long-term conditions often require information on survival beyond the period of available data.
Briggs, Andrew, Crowe, Lydia, Kapetanakis, Venediktos, Livings, Christopher, Tremblay, Gabriel   +4 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Incidence and risk factors of surgical site infection following cesarean section: a prospective cohort study at Jimma university medical center

BMC Infectious Diseases
Background Surgical site infection (SSI) after cesarean section (CS) is one of the contributors for high maternal mortality and morbidity rates. Aim This prospective cohort analysis assessed the incidence rate and risk factors of time to SSI following CS
Etagegn Shacho, Daniel Yilma, Ayele Taye Goshu, Argaw Ambelu   +3 more
doaj   +1 more source

Survival analysis of A.C. machines in the diamond industry using the Kaplan-Meier estimator

MATEC Web of Conferences, 2017
The article deals with the survival analysis of a.c. machines operating under the conditions of the underground mine “Mir” (Yakutia). The estimation of their survival is carried out using the Kaplan-Meier estimator.
Shevchuk Vladislav A., Muravlev Oleg P., Stolyarova Olga O.   +2 more
doaj   +1 more source

Crude Cumulative Incidence in the form of a Horvitz-Thompson like and Kaplan-Meier like Estimator [PDF]

, 2006
The link between the nonparametric estimator of the crude cumulative incidence of a competing risk and the Kaplan-Meier estimator is exploited. The equivalence of the nonparametric crude cumulative incidence to an inverse-probability-of-censoring ...
Antolini, Laura, Biganzoli, Elia Mario, Boracchi, Patrizia   +2 more
core   +1 more source

Life expectancy inequalities in the elderly by socioeconomic status. Evidence from Italy [PDF]

, 2018
Background: life expectancy considerably increased in most developed countries during the twentieth century. However, the increase in longevity is neither uniform nor random across individuals belonging to various socioeconomic groups. From an economic
Lallo, Carlo, Raitano, Michele
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source