Results 61 to 70 of about 7,810 (157)

KSHV and Human Diseases: Beyond KS, PEL and MCD

Microorganisms
Kaposi’s Sarcoma-associated herpesvirus (KSHV) has been etiologically linked to several human cancers, including Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease (MCD). However, recent studies suggest that KSHV
Caroline Grace Firmin, Lu Dai, Zhiqiang Qin   +2 more
doaj   +1 more source

CRISPR-Cas9 Screening of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Cells Identifies XPO1 as a Vulnerable Target of Cancer Cells

mBio, 2019
The abnormal proliferation of cancer cells is driven by deregulated oncogenes or tumor suppressors, among which the cancer-vulnerable genes are attractive therapeutic targets.
Marion Gruffaz, Hongfeng Yuan, Wen Meng, Hui Liu, Sangsu Bae, Jin-Soo Kim, Chun Lu, Yufei Huang, Shou-Jiang Gao   +8 more
doaj   +1 more source

Cells of the Innate and Adaptive Immune Systems in Kaposi’s Sarcoma

Journal of Immunology Research, 2020
Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is considered an AIDS ...
Owen Ngalamika, Sody Munsaka
doaj   +1 more source

Asymptomatic Violaceous Papules of the Penis in a Patient With HIV

JEADV Clinical Practice, EarlyView.
Jhon Edwin Rodríguez‐Vásquez, Gadwyn Sánchez‐Félix, Joseph Luigi Arzapalo‐Benavides, Adeliza Mariely Manrique‐Vera, Reynaldo Alberto Pomar‐Morante, Celia Betzabet Moisés‐Alfaro   +5 more
wiley   +1 more source

Potato Virus Y Coat Protein Interacts With Cytosolic Phosphoglucomutase and Reprogrammes Host Primary Metabolism During Disease Development

Molecular Plant Pathology, Volume 27, Issue 11, November 2026.
Potato virus Y (PVY) coat protein (CP) interacts with cytosolic phosphoglucomutase (cPGM) in the cytosol, redirecting carbohydrate flux towards respiratory and pentose phosphate pathways. Consequently, the plant cell can meet the increased ATP, NADPH and biosynthetic precursor requirements for viral RNA synthesis, thereby promoting PVY accumulation and
Prabu Gnanasekaran, Ying Zhai, Hanu R. Pappu   +2 more
wiley   +1 more source

Development of KSHV vaccine platforms and chimeric MHV68-K-K8.1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates

mBio
Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8 is an etiological agent of Kaposi’s Sarcoma, multicentric Castleman’s disease, and primary effusion lymphoma. Considering the high seroprevalence reaching up to 80% in sub-Saharan Africa,
Wan-Shan Yang, Dokyun Kim, Soowon Kang, Chih-Jen Lai, Inho Cha, Pei-Ching Chang, Jae U. Jung   +6 more
doaj   +1 more source

Immune reconstitution inflammatory syndrome, human herpesvirus 8 viremia, and HIV-associated multicentric Castleman disease

International Journal of Infectious Diseases, 2016
Kaposi's sarcoma and multicentric Castleman Disease are HIV-related disease processes that are associated with human herpesvirus 8 (HHV-8) infection.
Marc O. Siegel, Sanaz Ghafouri, Ravi Ajmera, Gary L. Simon   +3 more
doaj   +1 more source

Overview on Epstein–Barr Virus–Host Interactions With a Focus on Host Cell Transcriptome Alterations

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT The Epstein–Barr virus (EBV) belongs to the gamma subgroup of human herpesviruses. EBV is particularly lymphotropic regarding its latency, meaning that it preferentially targets lymphocytes as its immunological niche. During the establishment of the complex virus–host relationships, the virus influences the human host cell transcriptome ...
Louise Wallot, Tim Hohmann, Urszula Hohmann, Faramarz Dehghani, Olaf Grisk, Simon Jasinski‐Bergner   +5 more
wiley   +1 more source

Novel Virus Related to Kaposi’s Sarcoma–Associated Herpesvirus from Colobus Monkey

Emerging Infectious Diseases, 2019
We determined the complete genome sequence of a virus isolated from a mantled guereza that died of primary effusion lymphoma. The virus is closely related to Kaposi’s sarcoma–associated herpesvirus (KSHV) but lacks some genes implicated in KSHV ...
Akshay Dhingra, Tina Ganzenmueller, Elias Hage, Nicolás M. Suárez, Kerstin Mätz-Rensing, Dimitri Widmer, Stefan Pöhlmann, Andrew J. Davison, Thomas F. Schulz, Artur Kaul   +9 more
doaj   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source