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Evaluating the Role of the Kappa Opioid Receptor Nalfurafine in Preclinical Models of Demyelination [PDF]
Kendra Michelle Boyes
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Kappa Opioid Receptor Antagonists as Potential Therapeutics for Stress-Related Disorders.
Annual Review of Pharmacology and Toxicology, 2020Exposure to stressful stimuli activates kappa opioid receptor (KOR) signaling, a process known to produce aversion and dysphoria in humans and other species. This endogenous opioid system is dysregulated in stress-related disorders, specifically in major
Moriah L. Jacobson, C. Browne, I. Lucki
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Antagonists of the kappa opioid receptor
Bioorganic & Medicinal Chemistry Letters, 2014The research community has increasingly focused on the development of OPRK antagonists as pharmacotherapies for the treatment of depression, anxiety, addictive disorders and other psychiatric conditions produced or exacerbated by stress. Short-acting OPRK antagonists have been recently developed as a potential improvement over long-acting prototypic ...
Mariangela, Urbano +3 more
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ACS Chemical Neuroscience, 2019
Biased ligands preferentially activate certain signaling pathways downstream of their target receptor, leading to differential physiological or behavioral responses downstream.
Amelia D. Dunn +4 more
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Biased ligands preferentially activate certain signaling pathways downstream of their target receptor, leading to differential physiological or behavioral responses downstream.
Amelia D. Dunn +4 more
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Specific kappa opioid receptor agonists.
Farmaco (Societa chimica italiana : 1989), 2000The results of studies on the design of a heterocyclic scaffold for the dynorphin A pharmacophore and on structure-affinity relationships in the MPCB/CCB series are described. The representative ligands provide insights to binding modes of benzomorphan derivatives to the kappa opioid receptor.
RONSISVALLE, Giuseppe +5 more
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TENA, a selective kappa opioid receptor antagonist
Life Sciences, 1985A number of opioid antagonists (TENA, naloxone, Mr 2266, WIN 44441) were evaluated for their selectivity in antagonizing the effect of mu, kappa, and delta agonists in the guinea pig ileum (GPI) and mouse vas deferens (MVD) preparations. Among these four antagonists, TENA was the most potent and the only ligand which was selective for kappa receptors ...
P S, Portoghese, A E, Takemori
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Involvement of dynorphin and the kappa opioid receptor in feeding
Peptides, 1983Dynorphin-(1-17) produces a highly specific increase in food ingestion. Similar enhancement of food ingestion is found with dynorphin fragments (1-10), (1-11), (1-13) and (3-13) but not with (1-8) and (1-9). Dynorphin B (rimorphin) also enhances food intake.
J E, Morley, A S, Levine
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The kappa-opioid receptor: Evidence for the different subtypes
Life Sciences, 1993Classification of drugs acting on the kappa-opioid receptors seems to be difficult, since some of these ligands are also sigma agonists and/or display non-opioid actions as well. Furthermore, certain benzomorphans having kappa-agonistic character, are shown to be mu-antagonists too.
M, Wollemann, S, Benyhe, J, Simon
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PARTICIPATION OF CENTRAL KAPPA-OPIOID RECEPTOR IN ARRHYTHMOGENESIS
Life Sciences, 1997The effect of kappa receptors agonists and antagonists was studied in the model of epinephrine induced arrhythmias. Kappa receptor agonists U-50,488 and [D-Ala2]-Dynorphin A (1-13) administered I.C.V. potentiate the arrhythmogenic effect of epinephrine.
Y B, Lishmanov +3 more
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