The article describes the history, clinical picture and anatomopathological changes of Kashin-Beck disease with reference to the stages of the disease which are at present agreed upon. Specific reference is made to the occurrence of the disease in Tibet. An overview is given of the different proposed etiologies.
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Background: Kashin-Beck disease (KBD) is an endemic osteoarthropathy characterized by excessive chondrocytes apoptosis. T-2 toxin exposure has been proved to be its etiology. Connective tissue growth factor (CTGF) exerts a profound influence on cartilage
Xuena Yang +14 more
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Beijing conference reviews Kashin-Beck disease
Life is hard for Tibetan farmers in the impoverished, remote regions of the Himalayan plateau, and a little understood, disabling osteoarticular disorder-Kashin-Beck disease-is causing even greater economic difficulties for some rural inhabitants. A recent international symposium in Beijing, organised by Medecins Sans Frontiares (MSF) and the Chinese ...
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WISP1 Is Involved in the Pathogenesis of Kashin-Beck Disease via the Autophagy Pathway. [PDF]
Li P +16 more
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A Metabolomics Study of Feces Revealed That a Disturbance of Selenium-Centered Metabolic Bioprocess Was Involved in Kashin-Beck Disease, an Osteoarthropathy Endemic to China. [PDF]
Wen Y +7 more
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Health-related quality of life in patients with Kashin-Beck disease is lower than in those with osteoarthritis: a cross-sectional study. [PDF]
Jin Z +10 more
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Dietary and drinking water intake of essential trace elements in a typical Kashin-Beck disease endemic area of Tibet, China. [PDF]
Zha X, An J, Gao X, Tian Y.
europepmc +1 more source
Comprehensive comparative analysis of histopathology and gene expression in subchondral bone between kashin-beck disease and primary osteoarthritis. [PDF]
Yang L, Sun J, Zhang Y, Guo X, Zhao G.
europepmc +1 more source
Differences in Major Causes of Death and Disease Burden Among Residents of Kashin-Beck Disease Endemic and Non-Endemic Areas - Heilongjiang Province, China, 2024. [PDF]
Xing Z +8 more
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