Results 61 to 70 of about 1,061 (155)

Proteoglycan metabolism, cell death and Kashin-Beck Disease [PDF]

Glycoconjugate Journal, 2012
Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan ...
Li, Siyuan, Cao, Junling, Caterson, Bruce, Hughes, Clare E.   +3 more
openaire   +2 more sources

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim   +6 more
wiley   +1 more source

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 6, Page 1604-1619, June 2025.
(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen   +8 more
wiley   +1 more source

Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis

International Journal of Endocrinology, 2014
Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon-γ-inducible protein of 10 kDa (IP-10) in thyroid ...
Si-lu Cui, Jun Yu, Liu Shoujun
doaj   +1 more source

Geographical Patterns and Determinants of Selenium Deficiency in Tibet: A Cross‐Sectional Study Based on Urinary Selenium Analysis

Earth's Future, Volume 13, Issue 2, February 2025.
Abstract Selenium is an essential micronutrient, yet its deficiency poses severe health risks, including Kashin‐Beck disease, a debilitating disorder endemic to selenium‐deficient regions like Tibet. Despite the known risks, the extent and drivers of selenium deficiency in Tibetan populations remain poorly characterized.
Yi Yang, Ru Zhang, Yangzong Deji, You Li, Yonghua Li   +4 more
wiley   +1 more source

Arthroscopic Ankle Arthrodesis for Treating Osteoarthritis in a Patient with Kashin-Beck Disease

Case Reports in Medicine, 2014
Kashin-Beck disease (KBD) is an endemic degenerative osteoarthritis. Death of cartilage and growth plate is the pathologic feature; therefore, KBD involves skeletal deformity and often results in osteoarthritis.
Kenjiro Iwasa, Noriyuki Kanzaki, Takaaki Fujishiro, Shinya Hayashi, Shingo Hashimoto, Ryosuke Kuroda, Masahiro Kurosaka   +6 more
doaj   +1 more source

Dysregulation of Cells Cycle and Apoptosis in Human Induced Pluripotent Stem Cells Chondrocytes Through p53 Pathway by HT-2 Toxin: An in vitro Study

Frontiers in Genetics, 2021
Kashin–Beck disease (KBD) mainly damages growth plate of adolescents and is susceptible to both gene and gene–environmental risk factors. HT-2 toxin, which is a primary metabolite of T-2 toxin, was regarded as one of the environmental risk factors of KBD.
Yanan Zhang, Yanan Zhang, Huan Liu, Huan Liu, Xialu Lin, Xialu Lin, Feng’e Zhang, Feng’e Zhang, Peilin Meng, Peilin Meng, Sijia Tan, Sijia Tan, Mikko J. Lammi, Mikko J. Lammi, Xiong Guo, Xiong Guo   +15 more
doaj   +1 more source

Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis

Scientific Reports, 2017
Kashin-Beck disease (KBD) is a chronic osteochondropathy with unclear pathogeny. In this study, we compared the microRNA expression profiles of 16 KBD patients, 16 osteoarthritis (OA) patients and 16 rheumatoid arthritis (RA) patients and 16 healthy ...
Wenhong Wu, Awen He, Yan Wen, Xiao Xiao, Jingcan Hao, Feng Zhang, Xiong Guo   +6 more
doaj   +1 more source

Association study of polymorphisms in selenoprotein genes and Kashin-Beck disease and serum selenium/iodine concentration in a Tibetan population.

PLoS ONE, 2013
BackgroundKashin-Beck disease is a kind of degenerative osteoarthropathy. Genetic factors may play an important role in the pathogenesis of KBD.ObjectiveTo investigate the association of the selenoprotein genes GPX1 (rs1050450, rs1800668, and rs3811699),
Lulin Huang, Yi Shi, Fang Lu, Hong Zheng, Xiaoqi Liu, Bo Gong, Jiyun Yang, Ying Lin, Jing Cheng, Shi Ma, He Lin, Zhenglin Yang   +11 more
doaj   +1 more source

Evaluation of Soil Samples Preparation Techniques for Detecting Selenium by Using Atomic Fluorescence Spectroscopy‐Based Detection

Journal of Analytical Methods in Chemistry, Volume 2025, Issue 1, 2025.
Selenium (Se) can cause poisoning in the human body, including dry, brittle, and easy‐to‐fall‐off hair, white spots and longitudinal lines of nails, skin damage, nervous system abnormalities, and even death. In order to optimize the experimental process for the sensitive detection of Se in samples by atomic fluorescence spectrometry (AFS), an excellent
Lin Zhu, Zheng-he Hu, Xiu-long Chen, Surat Hongsibsong, Tulika Banerjee   +4 more
wiley   +1 more source