Results 51 to 60 of about 5,423,374 (131)

DNA regulatory motif selection based on support vector machine (SVM) and its application in microarray experiment of Kashin-Beck disease [PDF]

, 2013
Conserved DNA sequences are essential to investigate the regulation and expression of nearby genes. The conserved regions can interact with certain proteins and can potentially determine the transcription speed and amount of the corresponding mRNA in ...
Wang, X, Du, JQ, Zhang, M, Guo, X, Wu, XM, Wang, S   +5 more
core   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Extracellular vesicles derived from engineered BMSCs improve damaged cartilage in mice with osteoarthritis by delivering PBX1

Stem Cell Research & Therapy
Background The beneficial effects of bone marrow mesenchymal stem cells (BMSCs) have been linked to their secreted extracellular vesicles (EVs). These EVs can suppress cartilage degradation and prevent apoptosis in articular cells.
Yunqi Zhang, Fusen Wang, Huan Yu, Changqing Jiang, Zhong Li, Rongqiang Bu, Jun Yu   +6 more
doaj   +1 more source

Epidemiological Support for a Multifactorial Aetiology of Kashin-Beck Disease in Tibet. [PDF]

, 2001
We carried out a cross-sectional study in 12 rural villages in order to identify the risk factors for Kashin-Beck disease in Tibet. Children aged 5-15 years (n=575) were examined and their corresponding houses were visited.
R. Moreno-Reyes, Vanderpas, J, Mathieu, F, Durand, M. C., Haubruge, Eric, E. Haubruge, Suetens, C, F. Begaux, Haubruge, E, Moreno-Reyes, R, Chasseur, C., Chasseur, C, Nève, J, Moreno-Reyes, R., Durand, M, Begaux, F., F. Mathieu, Suetens, C., Mathieu, F., Neve, J., J. Nève, M.C. Durand, Begaux, F, C. Chasseur, Vanderpas, J., J. Vanderpas, C. Suetens   +26 more
core   +1 more source

Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis

International Journal of Endocrinology, 2014
Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon-γ-inducible protein of 10 kDa (IP-10) in thyroid ...
Si-lu Cui, Jun Yu, Liu Shoujun
doaj   +1 more source

The role of humic substances in drinking water in Kashin-Beck disease in China

, 1999
We conducted in vitro and in vivo assays in a selenium-deficient system to determine if organic matter (mainly fulvic acid; FA) is involved in a free radical mechanism of action for Kashin-Beck disease.
Z W Yang, C X Wang, Yang, ZW, Wang, WZ, Wang, ZJ, H F Rui, W H Wang, Peng, A, Rui, HF, Wang, CX, Z J Wang, A Peng, Wang, WH, W Z Wang   +13 more
core   +1 more source

Comparison of microRNA expression profiles of Kashin-Beck disease, osteoarthritis and rheumatoid arthritis

Scientific Reports, 2017
Kashin-Beck disease (KBD) is a chronic osteochondropathy with unclear pathogeny. In this study, we compared the microRNA expression profiles of 16 KBD patients, 16 osteoarthritis (OA) patients and 16 rheumatoid arthritis (RA) patients and 16 healthy ...
Wenhong Wu, Awen He, Yan Wen, Xiao Xiao, Jingcan Hao, Feng Zhang, Xiong Guo   +6 more
doaj   +1 more source

Radiological Abnormalities and Clinical Characteristics for Children with Kashin-Beck Disease in Tibet

, 2011
A radiological study and clinical characteristics in Kashin-Beck Disease (KBD) was undertaken on the appendicular skeleton in 213 patients with KBD in Tibet , in 134 healthy subjects living in an endemic area and in 61 healthy subjects living in a non ...
Min Zhang, Wen Hua Li, Zhong Liu
core   +1 more source

Supplementary files of a manuscript entiled "Comprehensive expression profiles of mRNAs, lncRNAs and miRNAs in Kashin-Beck Disease identified by RNA-sequencing"

, 2021
These part of the content are some supplementary files of a manuscript entitled " Comprehensive expression profiles of mRNAs, lncRNAs and miRNAs in Kashin-Beck Disease identified by RNA-sequencing " Abstract: Kashin-Beck disease (KBD) is a chronic ...
Dai Yu
core   +1 more source

Genetic variants in the ITPR2 gene are associated with Kashin‐Beck Disease in Tibetan

Molecular Genetics & Genomic Medicine, 2019
Background Kashin‐Beck Disease (KBD) is a chronic, endemic osteoarthropathy. Inositol 1,4,5‐triphosphate receptor type 2 (ITPR2) gene is involved in chondrocytes.
Xue He, Mei Bai, Ming Liu, Li Wang, Yongjun He, Hao Rong, Dongya Yuan, Tianbo Jin   +7 more
doaj   +1 more source