Results 51 to 60 of about 1,047 (156)

The Silent Shift: Investigating Selenium Biovolatilization in Natural Environments

Reviews of Geophysics, Volume 63, Issue 4, December 2025.
Abstract Selenium (Se) is essential for human health. Organisms produce volatile Se through metabolism, which is an essential but hidden component of the Se geochemical cycle. Understanding this natural cycle is vital for sustainable development and ecosystem protection, thereby preserving planetary health and fostering harmonious coexistence between ...
Ruixuan Zhang, Xiaoping Wang, Yunqiao Zhou, Lei Chai, Jiamin Zeng, Li Xu   +5 more
wiley   +1 more source

Association study of candidate genes for susceptibility to Kashin-Beck disease in a Tibetan population

BMC Medical Genetics, 2017
Background Many osteoarthritis (OA) susceptibility genes have been identified in recent years. Given the overlap in the phenotype of joint inflammation between OA and Kashin-Beck disease (KBD), the aim of this study is to explore whether the reported OA ...
Zhengfu Tai, Lulin Huang, Fang Lu, Yi Shi, Shi Ma, Jing Cheng, He Lin, Xin Liu, Yuanfeng Li, Zhenglin Yang   +9 more
doaj   +1 more source

Investigation of selenium nutritional status and dietary pattern among children in Kashin-Beck disease endemic areas in Shaanxi Province, China using duplicate portion sampling method

Environment International, 2022
Background and objectives: Selenium deficiency is a primary risk factor of Kashin-Beck disease (KBD). This study aimed to investigate whether children in endemic areas could maintain sufficient selenium intake after termination of selenium supplement ...
Yujie Ning, Minhan Hu, Sijie Chen, Feiyu Zhang, Xiaodong Yang, Qingping Zhang, Yi Gong, Ruitian Huang, Yanli Liu, Feihong Chen, Leilei Pei, Xiong Guo, Lianke Kang, Xinyi Wang, Yan Zhang, Xi Wang   +15 more
doaj   +1 more source

Proteoglycan metabolism, cell death and Kashin-Beck Disease [PDF]

Glycoconjugate Journal, 2012
Kashin-Beck Disease (KBD) is an endemic, chronic and degenerative osteoarthropathy principally occurring in children. The characteristic pathological change of KBD is chondrocyte necrosis in hyaline articular cartilage. Proteoglycans are one of the major components in the extracellular matrix of articular cartilage, and disrupted proteoglycan ...
Li, Siyuan, Cao, Junling, Caterson, Bruce, Hughes, Clare E.   +3 more
openaire   +2 more sources

Ictal Asystole in a Patient With DEE due to an FGF12 Pathogenic Variant: A Reminder to Monitor Cardiac Function

Clinical Genetics, Volume 108, Issue 4, Page 486-487, October 2025.
We report the first known case of a 9‐year‐old male with early‐onset epilepsy, syncope, and ictal asystole–requiring pacemaker implantation at the age of seven–associated with a pathogenic variant in FGF12.
Johanne Piotrowski, Élise Schaefer, Michael Kuntz, Virginie Bois, Franz Schieffer, Laurence Jesel, Margaux Biehler, Anne De Saint Martin, Sarah Baer   +8 more
wiley   +1 more source

COL9A1 gene polymorphism is associated with Kashin-Beck disease in a northwest Chinese Han population. [PDF]

PLoS ONE, 2015
OBJECTIVE: We sought to determine whether genomic polymorphism in collagen IX genes (COL9A) was associated with Kashin-Beck disease (KBD). METHODS: Twenty seven single nucleotide polymorphisms (SNPs) in COL9AI, COL9A2 and COL9A3 were genotyped in 274 KBD
Xiaowei Shi, Feng Zhang, Aili Lv, Yan Wen, Xiong Guo   +4 more
doaj   +1 more source

New Glycoconjugates Containing Selenium and Polyphenols. Stereoselective Synthesis by Pummerer‐like Rearrangement.

European Journal of Organic Chemistry, Volume 28, Issue 26, July 12, 2025.
Two series of novel six‐membered Se‐glycoconjugates containing hydroxycinnamic acids marked by well‐known antioxidant properties are synthesized, exploiting a Mitsunobu reaction and a Pummerer‐like rearrangement. A first example of six‐membered selenosugar with selenium in the ring and bearing an acetal‐like functional group at C‐1 was reported, which ...
Claudia González, Mauro De Nisco, Reinier Lemos, Giovanna Cimmino, Yoana Pérez‐Badell, Severina Pacifico, Silvana Pedatella   +6 more
wiley   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim   +6 more
wiley   +1 more source

LRP1 Mediates Endocytosis Activity and Is a Potential Therapeutic Target in Osteoarthritis

Orthopaedic Surgery, Volume 17, Issue 6, Page 1604-1619, June 2025.
(A) The risk factors associated with OA development. (B) Exosomes derived from TNF‐α stimulate upregulation of LRP1 levels in IPFP‐MSC‐derived exosomes, thereby exerting chondroprotective effects. (C) The regulation of endocytosis by LRP1, which impacts chondrocyte proliferation and apoptosis.
Yuangang Wu, Kaibo Sun, Mingyang Li, Yang Yang, Yuan Liu, Limin Wu, Yang Ding, Yi Zeng, Bin Shen   +8 more
wiley   +1 more source