Results 161 to 170 of about 14,110 (214)

Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and K_ATP channel function in the atrium from patients with atrial fibrillation. [PDF]

Cell Commun Signal
Hou HT, Wang XC, Chen HX, Wang J, Yang Q, He GW.   +5 more
europepmc   +1 more source

Expression levels of K_ATP channel subunits and morphological changes in the mouse liver after exposure to radiation. [PDF]

World J Exp Med
Zhou M, Li TS, Abe H, Akashi H, Suzuki R, Bando Y.   +5 more
europepmc   +1 more source

Regulation of mitochondrial KATP channels

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
openaire   +1 more source

Binding of sulphonylureas to plasma proteins - A KATP channel perspective. [PDF]

PLoS One, 2018
Proks P, Kramer H, Haythorne E, Ashcroft FM.   +3 more
europepmc   +1 more source

Nature's KATP-Channel Knockout

Physiology, 1997
We describe here how ion-channel dysfunction in b-cells is associated with the pathogenesis of a potentially lethal condition in newborn children and early infancy. We review how nature's KATP-channel knockout has important medical implications and how key lessons in physiology can be learned from studies of rare diseases.
MJ Dunne, A Aynsley-Green, KJ Lindley
openaire   +2 more sources

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KATP channels and memory of ischemic preconditioning in dogs: synergism between adenosine and KATP channels

American Journal of Physiology-Heart and Circulatory Physiology, 1997
Results from numerous studies have shown that there is an important link between adenosine A1 receptors and ATP-sensitive potassium (KATP) channels in mediating the cardioprotective effects of ischemic preconditioning (PC). The major aim of the present study was to determine whether occupation of A1 receptors and/or the opening of KATP channels is ...
Z, Yao, T, Mizumura, D A, Mei, G J, Gross   +3 more
openaire   +2 more sources

Modulation of vascular KATP channels in hypothyroidism

European Journal of Pharmacology, 1996
The role of vascular KATP channels in hypothyroidism-induced decrease in myogenic activity of rat portal vein was examined by using pharmacologically relevant concentrations of K+ channel ligands. As compared to controls, a significant decrease in the myogenic tone and noradrenaline (10(-9)-10(-5) M)-induced contractions was observed in portal veins ...
M, Jagadish, V, Raviprakash, A G, Telang, S K, Mishra   +3 more
openaire   +2 more sources

KATP channel mutations in congenital hyperinsulinism

Seminars in Pediatric Surgery, 2011
Adenosine triphosphate (ATP)-sensitive potassium channels (K(ATP) channels) have a central role in the regulation of insulin secretion in pancreatic β cells. They are octameric complexes organized around the central core constituted by the Kir6.2 subunits. The regulation of the channel itself takes place on the sulfonylurea receptor-1 subunit.
Cécile, Saint-Martin, Jean-Baptiste, Arnoux, Pascale, de Lonlay, Christine, Bellanné-Chantelot   +3 more
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KATP channels in vascular smooth muscle

Cardiovascular Research, 1994
ATP sensitive potassium channels (KATP channels) appear widely distributed in the vascular system. At the single channel level, channels with both small and large conductance have been described, though the former appear to be activated by potassium channel openers or ATP depletion in whole cell studies.
J M, Quayle, N B, Standen
openaire   +2 more sources

Pharmacological modulation of KATP channels

Biochemical Society Transactions, 2001
Pharmacological modulation of ATP-sensitive K+ (KATP) channels is used in the treatment of a number of clinical conditions, including type 2 diabetes and angina. The sulphonylureas and related drugs, which are used to treat type 2 diabetes, stimulate insulin secretion by closing KATP channels in pancreatic β-cells.
F. M. Gribble, F. Reimann
openaire   +1 more source