Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain
Cell Reports, 2016 Summary: Chronic neuropathic pain is a debilitating condition that remains difficult to treat. Diminished synaptic inhibition by GABA and glycine and increased NMDA receptor (NMDAR) activity in the spinal dorsal horn are key mechanisms underlying ...
Lingyong Li +6 more
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Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice [PDF]
, 2023 Rebecca M. Jarvis +21 more
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Inflammation alters cation chloride cotransporter expression in sensory neurons
Neurobiology of Disease, 2004 Cation chloride cotransporters have been proposed to play a role in the modulation of neuronal responses to γ-aminobutyric acid (GABA). In conditions of neuronal damage, where neuronal excitability is increased, the expression of the KCC2 transporter is ...
Begonia M. Morales-Aza +3 more
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Research on ionic homeostatic equilibrium may change our view about epilepsy [PDF]
, 2013 Universidade Federal de Sao Joao Del Rei (UFSJ) Departamento de Engenharia de Biossistemas (DEPEB) Laboratorio de Neurociencia Experimental e Computacional Dr Aristides Azevedo Pacheco LeaoUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de ...
Almeida, Antonio Carlos G. de +4 more
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Hippocampe et épilepsie : données issues des tissus humains [PDF]
, 2015 International audienceSurgical removal of the epileptogenic zone provides an effective therapy for several focal epileptic syndromes. This surgery offers the opportunity to study pathological activity in living human tissue for pharmacoresistant partial ...
Blauwblomme, Thomas +2 more
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iScienceSummary: LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk factor for autism and epilepsy, its physiological significance is ...
Noell Cho +11 more
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Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
Frontiers in Cellular Neuroscience, 2014 In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i).
Igor eMedina +13 more
doaj +1 more source
Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain [PDF]
, 2015 Aline Winkelmann +2 more
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Silencing KCC2 in mouse dorsal hippocampus compromises spatial and contextual memory [PDF]
, 2022 Clémence Simonnet +5 more
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The Kainate Receptor Subunit GluK2 Interacts With KCC2 to Promote Maturation of Dendritic Spines
, 2020 Sebnem Kesaf +9 more
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