Hippocampe et épilepsie : données issues des tissus humains [PDF]
, 2015 International audienceSurgical removal of the epileptogenic zone provides an effective therapy for several focal epileptic syndromes. This surgery offers the opportunity to study pathological activity in living human tissue for pharmacoresistant partial ...
Blauwblomme, Thomas +2 more
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The Neuron-specific K-Cl Cotransporter, KCC2 [PDF]
, 1999 Jeffery Williams +4 more
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KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients
Acta Neuropathologica Communications, 2019 Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the Methyl CpG binding protein 2 (MECP2) gene. Deficient K+-Cl—co-transporter 2 (KCC2) expression is suggested to play a key role in the neurodevelopmental delay in RTT patients’
Lisa Hinz +2 more
doaj +1 more source
General anaesthetics do not impair developmental expression of the KCC2 potassium-chloride cotransporter in neonatal rats during the brain growth spurt [PDF]
, 2017 Background The developmental transition from depolarizing to hyperpolarizing γ-aminobutyric acid-mediated neurotransmission is primarily mediated by an increase in the amount of the potassium-chloride cotransporter KCC2 during early postnatal life ...
Bodogan, T. +6 more
core
Heterogeneous Expression of the Potassium-Chloride Cotransporter KCC2 in Gonadotropin-Releasing Hormone Neurons of the Adult Mouse [PDF]
, 2003 Sarah Leupen +3 more
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Pathophysiological role of extrasynaptic GABAA receptors in typical absence epilepsy [PDF]
, 2011 GABA is the principal inhibitory neurotransmitter in the mammalian CNS. It acts via two classes of receptors, the GABAA, a ligand gated ion channel (ionotropic receptor) and the metabotropic G-protein coupled GABAB receptor.
Crunelli, Vincenzo +2 more
core
Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity. [PDF]
, 2015 BACKGROUND: Voltage-sensitive dye (VSD) imaging and intrinsic optical signals (IOS) are widely used methods for monitoring spatiotemporal neural activity in extensive networks.
Dobolyi, Arpád +3 more
core +1 more source
Differential distribution of the KCl cotransporter KCC2 in thalamic relay and reticular nuclei [PDF]
, 2004 Péter Barthó +3 more
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Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
Frontiers in Cellular Neuroscience, 2012 The K-Cl co-transporter KCC2 plays multiple roles in the physiology of central neurons and alterations of its function and/or expression are associated with several neurological conditions.
Ingrid eChamma +3 more
doaj +1 more source
Mechanism of Activity-Dependent Downregulation of the Neuron-Specific K-Cl Cotransporter KCC2 [PDF]
, 2004 Claudio Rivera +9 more
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