WNK Kinase Signaling in Ion Homeostasis and Human Disease [PDF]
This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters
Delpire, Eric+5 more
core +3 more sources
Brain‐derived neurotrophic factor (BDNF) is not only the main neurotrophic signal in the human body but also an important neuromodulator. BDNF and its receptors are widely distributed throughout the central nervous system. They promote neuronal survival and growth and protect neurons.
Min Lei+7 more
wiley +1 more source
GABAA receptors mediate inhibitory neurotransmission and are key for maintaining the excitatory/inhibitory balance throughout the brain. Genetic variants in GABAA receptor subunits were among the earliest to be associated with epilepsy, and several hundreds of variants have since been linked to epileptic syndromes.
Nathan L. Absalom+6 more
wiley +1 more source
Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing [PDF]
In chronic pain states, the neurotrophin brain-derived neurotrophic factor (BDNF) transforms the output of lamina I spinal neurons by decreasing synaptic inhibition.
Beggs, S+7 more
core +1 more source
KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders.
Marie Goutierre+7 more
doaj
Symptomatic seizures in preterm newborns: a review on clinical features and prognosis [PDF]
Neonatal seizures are the most common neurological event in newborns, showing higher prevalence in preterm than in full-term infants. In the majority of cases they represent acute symptomatic phenomena, the main etiologies being intraventricular ...
Corsello G+4 more
core +2 more sources
Summary: It is generally thought that hippocampal neurons of perinatal rats and mice lack transport-functional K-Cl cotransporter KCC2, and that Cl− regulation is dominated by Cl− uptake via the Na-K-2Cl cotransporter NKCC1. Here, we demonstrate a robust
Inkeri Spoljaric+5 more
doaj
Development of GABAergic and glycinergic transmission in the neonatal rat dorsal horn [PDF]
Cutaneous spinal sensory transmission appears to lack inhibitory control in the newborn spinal cord, but the properties of GABAergic and glycinergic synapses in the neonatal dorsal horn have not been characterized.
Baccei, ML, Fitzgerald, M
core +1 more source
Current view on the functional regulation of the neuronal K+-Cl- cotransporter KCC2
In the mammalian central nervous system, the inhibitory strength of chloride (Cl-)-permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular Cl- concentration ([Cl-]i).
Igor eMedina+13 more
doaj +1 more source
Interleukin-1 receptor type 1 is over-expressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant induced inflammatory pain [PDF]
K
Antal, Miklós+10 more
core +1 more source