Results 71 to 80 of about 3,487 (142)

NMDA‐Type Glutamate Receptor Activation Promotes Ischemic Arrhythmias by Targeting the AKT1–TBX3–Nav1.5 Axis

Acta Physiologica, Volume 241, Issue 9, September 2025.
ABSTRACT Aim The aim of this study is to determine the possible role of N‐methyl‐D‐aspartate receptor (NMDAR) dysregulation in the ischemic electrical remodeling observed in patients with myocardial infarction (MI) and elucidate the underlying mechanisms.
Yuxian He, Han Zhang, Qinggang Zhang, Zewei Sun, Xingang Sun, Ling Xia, Liangrong Zheng, Lihong Wang   +7 more
wiley   +1 more source

A Lung Transcriptomic Analysis for Exploring Host Response in COVID-19

Journal of Pure and Applied Microbiology, 2020
Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) rose without precedent for Wuhan, China, in December 2019. It is a kind of exceptionally pathogenic human coronavirus (HCoV) which causes zoonotic sicknesses and represents a significant ...
Aditya Saxena, Uma Chaudhary, Alok Bharadwaj, Nitin Wahi, Jitender Reddy Kalli, Shravya Gupta, Sparsh Kumar, Somya Gupta, Utkarsh Raj   +8 more
doaj   +1 more source

The Utility of Notched P‐Wave on the Occurrence of Ventricular Fibrillation in Patients With Brugada Syndrome

Journal of Arrhythmia, Volume 41, Issue 4, August 2025.
Notched P‐waves on 12‐lead ECG are significantly associated with ventricular fibrillation in Brugada syndrome, suggesting their potential relevance in identifying patients at increased arrhythmic risk. ABSTRACT Background Risk stratification for ventricular fibrillation (VF) in patients with Brugada syndrome (BrS) remains a significant clinical ...
Keisuke Yonezu, Tetsuji Shinohara, Masaki Takahashi, Taisuke Harada, Kazuki Mitarai, Masayuki Takano, Kei Hirota, Ichitaro Abe, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Naohiko Takahashi   +12 more
wiley   +1 more source

Characterization of a novel KCNJ2 sequence variant detected in Andersen-Tawil syndrome patients

BMC Medical Genetics, 2017
Background Mutations in the KCNJ2 gene encoding the ion channel Kir2.1 have been linked to the Andersen-Tawil syndrome (ATS). Molecular genetic screening performed in a family exhibiting clinical ATS phenotypes unmasked a novel sequence variant (c.434A > 
Stefanie Scheiper, Brigitte Hertel, Britt-Maria Beckmann, Stefan Kääb, Gerhard Thiel, Silke Kauferstein   +5 more
doaj   +1 more source

Andersen-Tawil Syndrome

Indian Pacing and Electrophysiology Journal, 2006
Andersen-Tawil syndrome (ATS) is a rare condition consisting of ventricular arrhythmias, periodic paralysis, and dysmorphic features. In 2001, mutations in KCNJ2, which encodes the α subunit of the potassium channel Kir2.1, were identified in patients ...
Andrew H. Smith, Frank A. Fish, Prince J. Kannankeril   +2 more
doaj  

Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3.

PLoS ONE, 2013
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity, affecting around 2% of adolescents worldwide. Genetic factors play an important role in its etiology.
Atsushi Miyake, Ikuyo Kou, Yohei Takahashi, Todd A Johnson, Yoji Ogura, Jin Dai, Xusheng Qiu, Atsushi Takahashi, Hua Jiang, Huang Yan, Katsuki Kono, Noriaki Kawakami, Koki Uno, Manabu Ito, Shohei Minami, Haruhisa Yanagida, Hiroshi Taneichi, Naoya Hosono, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Toshiaki Kotani, Ikuho Yonezawa, Michiaki Kubo, Tatsuhiko Tsunoda, Kota Watanabe, Kazuhiro Chiba, Yoshiaki Toyama, Yong Qiu, Morio Matsumoto, Shiro Ikegawa   +30 more
doaj   +1 more source

Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7

Journal of Translational Medicine
Objective Long QT syndrome type 7 (Andersen–Tawil syndrome, ATS), which is caused by KCNJ2 gene mutation, often leads to ventricular arrhythmia, periodic paralysis and skeletal malformations.
Peipei Chen, Junyu Long, Tianrui Hua, Zhifa Zheng, Ying Xiao, Lianfeng Chen, Kang Yu, Wei Wu, Shuyang Zhang   +8 more
doaj   +1 more source

Exploring the transcriptomic landscape of moyamoya disease and systemic lupus erythematosus: insights into crosstalk genes and immune relationships

Frontiers in Immunology
BackgroundSystemic Lupus Erythematosus (SLE) is acknowledged for its significant influence on systemic health. This study sought to explore potential crosstalk genes, pathways, and immune cells in the relationship between SLE and moyamoya disease (MMD ...
Qingbao Guo, Qingbao Guo, Qingbao Guo, Yan-Na Fan, Manli Xie, Qian-Nan Wang, Jingjie Li, Jingjie Li, Jingjie Li, Simeng Liu, Simeng Liu, Simeng Liu, Xiaopeng Wang, Xiaopeng Wang, Xiaopeng Wang, Dan Yu, Zhengxing Zou, Gan Gao, Gan Gao, Gan Gao, Qian Zhang, Fangbin Hao, Fangbin Hao, Fangbin Hao, Jie Feng, Rimiao Yang, Minjie Wang, Minjie Wang, Minjie Wang, Heguan Fu, Xiangyang Bao, Lian Duan   +31 more
doaj   +1 more source

811-1 Frequency, spectrum, and phenotype of KCNJ2 mutations among patients referred for long QT (LQT) syndrome genetic testing: Is KCNJ2 LQT7?

Journal of the American College of Cardiology, 2004
Rodriguez, Esther H, Hammill, Daniel, Tester, David J, Ackerman, Michael J   +3 more
openaire   +1 more source

Congenital Short QT Syndrome

Indian Pacing and Electrophysiology Journal, 2010
The Short QT Syndrome is a recently described new genetic disorder, characterized by abnormally short QT interval, paroxysmal atrial fibrillation and life threatening ventricular arrhythmias. This autosomal dominant syndrome can afflict infants, children,
Lia Crotti, Erika Taravelli, Giulia Girardengo, Peter J. Schwartz   +3 more
doaj