Results 101 to 110 of about 3,925 (184)

Centipede KCNQ Inhibitor SsTx Also Targets K_V1.3

Toxins, 2019
It was recently discovered that Ssm Spooky Toxin (SsTx) with 53 residues serves as a key killer factor in red-headed centipede’s venom arsenal, due to its potent blockage of the widely expressed KCNQ channels to simultaneously and efficiently ...
Canwei Du, Jiameng Li, Zicheng Shao, James Mwangi, Runjia Xu, Huiwen Tian, Guoxiang Mo, Ren Lai, Shilong Yang   +8 more
doaj   +1 more source

An Epithelial Ca2+-Sensor Protein is an Alternative to Calmodulin to Compose Functional KCNQ1 Channels

Cellular Physiology and Biochemistry, 2015
Background/Aims: KCNQ channels transport K+ ions and participate in various cellular functions. The channels directly assemble with auxiliary proteins such as a ubiquitous Ca2+-sensor protein, calmodulin (CaM), to configure the physiological properties ...
Atsushi Inanobe, Chizuru Tsuzuki, Yoshihisa Kurachi   +2 more
doaj   +1 more source

Whole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss

Scientific Reports, 2018
Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked to a type of nonsyndromic hearing loss, deafness nonsyndromic autosomal dominant 2 (DFNA2).
Jinsei Jung, Hyun Been Choi, Young Ik Koh, John Hoon Rim, Hye Ji Choi, Sung Huhn Kim, Jae Hyun Lee, Jieun An, Ami Kim, Joon Suk Lee, Sun Young Joo, Seyoung Yu, Jae Young Choi, Tong Mook Kang, Heon Yung Gee   +14 more
doaj   +1 more source

Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current.

PLoS ONE, 2015
The hypothalamus is a key element of the neural circuits that control energy homeostasis. Specific neuronal populations within the hypothalamus are sensitive to a variety of homeostatic indicators such as circulating nutrient levels and hormones that ...
Dong Kun Lee, Jae Hoon Jeong, Seunghoon Oh, Young-Hwan Jo   +3 more
doaj   +1 more source

Ethanol sensitivity is similar between aged flies and KCNQ loss-of-function mutants.

, 2012
The sensitivity of flies to the sedative effect of 40% ethanol was compared between young (5 days) and aged (30 days, black bars) flies of the same genotype (n≥4, ∼100 flies per n).
James J. L. Hodge (116854), John M. Gillespie (116852), Sonia Cavaliere (116850)   +2 more
core   +1 more source

KCNQ Kanalak eta Parazetamola: Epilepsiaren Tratamendurako Aukera Bat?

EKAIA Euskal Herriko Unibertsitateko Zientzia eta Teknologia Aldizkaria
KCNQ kanalek, Kv7 kanal izenez ere ezagunak, funtsezko rola dute zelulen kitzikagarritasunaren erregulazioan eta mintz-potentzialaren mantentzean. Ioi-kanal hauek ezinbestekoak dira hainbat prozesu fisiologikotan, hala nola ekintza-potentzialen modulazioan eta neurotransmisoreen askapenean.
Eider Nuñez Viadero, Sara Alicante, Naia Sanchez, Janire Urrutia, Arantza Muguruza, Markel Ibarluzea, Alvaro Villarroel   +6 more
openaire   +1 more source

Electrophysiological, pharmacological and behavioural characterisation of the Drosophila KCNQ channel

, 2011
There are five KCNQ (Kv7) channels in humans. The cardiac KCNQl channel when assembled with KCNEl mediates the cardiac IKs current with mutations causing short and long QT cardiac arrhythmias.
Cavaliere, Sonia
core  

Electrophysiological characterisation of KCNQ channel modulators

, 2003
Potassium (K+) ion channels are ubiquitously expressed in mammalian cells, and each channel serves a precise physiological role due to its specific biophysical characteristics and expression pattern.
Schrøder, R.L
core  

K_V7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth. [PDF]

Commun Med (Lond)
Mansour YT, Mistry HD, Chin-Smith EC, Zaleska MK, Sekulich DC, Herington JL, Reese J, Patel R, Aaronson PI, Slater DM, England SK, Greenwood IA, Johnson MR, Taylor PD, Tribe RM.   +14 more
europepmc   +1 more source

Ionic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics. [PDF]

Int J Mol Sci
Seo Y.
europepmc   +1 more source