Results 91 to 100 of about 3,925 (184)
Muscle &Nerve, Volume 73, Issue 4, Page 668-674, April 2026.Pretreatment with an agonist of Kv7 potassium channels (XEN1101) protects the soleus muscle from a loss of force during a 2 mM K+ challenge, in a mouse model of hypokalemic periodic paralysis. ABSTRACT Introduction/Aims Effective management remains lacking for recurrent episodes of acute weakness in hypokalemic periodic paralysis (HypoPP).
Viktor Chanchykov +4 more
wiley +1 more source
Journal of Neurochemistry, Volume 170, Issue 4, April 2026.Seizures can trigger a surge in brain‐driven autonomic signals, causing dangerous changes in heart rhythm and breathing. This ‘storm’ increases stress on the heart, leading to prolonged QT intervals and arrhythmias, while also slowing breathing and causing low oxygen levels. When these effects occur together, they create a vicious cycle that can result
Hian M. Lee +5 more
wiley +1 more source
Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice
Annals of Neurology, Volume 99, Issue 3, Page 809-824, March 2026.A[Color figure can be viewed at www.annalsofneurology.org] Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone
Soudabeh Naderi +10 more
wiley +1 more source
KCNQ signalling is required for long-term memory.
, 2013 A.
James J. L. Hodge (116854) +2 more
core +1 more source
Direct neurotransmitter activation of voltage-gated potassium channels
Nature Communications, 2018 M-current is conveyed by voltage-sensitive KCNQ channels, which are enriched in GABAergic neurons and are activated by anticonvulsants such as retigabine.
Rían W. Manville +2 more
doaj +1 more source
KCNQ signalling is required in the mushroom body α and β neurons for short-term memory.
, 2013 A.–C. Adult brains containing a Gal4 enhancer trap (KCNQNP3423) in the KCNQ gene locus revealed broad neuronal expression of KCNQ (labelled by membrane bound GFP in green (B)) especially in the fly memory structures of the mushroom body α and β neurons ...
James J. L. Hodge (116854) +2 more
core +1 more source
The M-Channel Blocker Linopirdine Is an Agonist of the Capsaicin Receptor TRPV1
Journal of Pharmacological Sciences, 2010 .: Linopirdine is a well known blocker of voltage-gated potassium channels from the Kv7 (or KCNQ) family that generate the so called M current in mammalian neurons.
Cristian Neacsu, Alexandru Babes
doaj +1 more source
Beteiligung von KCNQ Kanälen an der myogenen Reaktion kleiner Skelettmuskelarterien [PDF]
, 2015 Es wurde die Hypothese überprüft, dass XE991 und Linopiridin durch Inhibition von KCNQ-Kanälen kleine Arterien kontrahieren und damit die myogene Reaktion beeinflussen.
Stavrakas, Eva (gnd: 1075739454)
core +1 more source
Glial KCNQ K+ Channels Control Neuronal Output by Regulating GABA Release from Glia in C. elegans
KCNQ channels are voltage-gated K+ channels that are evolutionarily conserved across species. Among the five genes responsible for encoding KCNQ channels in humans, four are expressed in the nervous system. KCNQs display a low threshold of activation and
Graziano, Bianca
core +4 more sources
Kv7 (KCNQ) potassium channels that are mutated in human diseases [PDF]
The Journal of Physiology, 2008 Kv7 channels are a small family of voltage-gated potassium channel subunits (Kv7.1–Kv7.5) that are encoded by the KCNQ genes (KCNQ1–5) (reviewed by Jentsch, 2000; and by Robbins, 2001). Structurally, they resemble other Kv channels, with six transmembrane domains, a voltage sensor in the fourth (S4) domain, and a pore loop between the S5 and S6 domains,
openaire +2 more sources