Results 71 to 80 of about 3,925 (184)
Pathophysiology of KCNQ Channels: Neonatal Epilepsy and Progressive Deafness [PDF]
Epilepsia, 2000 Over the past 10 years, an increasing number of inherited diseases were shown to be due to mutations in ion channels. Given the importance of ion channels for the signal transduction in nerve and muscle, many of these “channelopathies” affect the neuromuscular system.
T J, Jentsch +4 more
openaire +2 more sources
KCNQ in dopaminergic neurons regulates ethanol sensitivity behaviour.
, 2012 A. Ethidium-bromide-stained agarose gel containing products of semi-quantitative PCR, showing removal of KCNQ in the KCNQ mutant, reduced KCNQ from flies expressing KCNQ-RNAi in all neurons (Elav-Gal4) and increased KCNQ from flies overexpressing KCNQ in
James J. L. Hodge (116854) +2 more
core +1 more source
Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Molecular Brain, 2022 Previous immunohistochemical studies have shown the expression of KCNQ2 channels at nodes of Ranvier (NRs) of myelinated nerves. However, functions of these channels at NRs remain elusive.
Sotatsu Tonomura +2 more
doaj +1 more source
Structural Insight into KCNQ (Kv7) Channel Assembly and Channelopathy [PDF]
Neuron, 2007 Kv7.x (KCNQ) voltage-gated potassium channels form the cardiac and auditory I(Ks) current and the neuronal M-current. The five Kv7 subtypes have distinct assembly preferences encoded by a C-terminal cytoplasmic assembly domain, the A-domain Tail.
Howard, Rebecca J. +3 more
openaire +2 more sources
British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim +5 more
wiley +1 more source
Pinpointing Calmodulin on Functioning KCNQ Channels [PDF]
Biophysical Journal, 2011 Calmodulin (CaM) is a ubiquitous intracellular calcium sensor that associates with and modulates several different classes of ion channel complexes. Although crystallographic studies have provided molecular insight into CaM binding using isolated peptide fragments of ion channels, the location and orientation of CaM bound to fully folded channels in ...
Mruk, Karen +2 more
openaire +1 more source
Ghrelin signaling in the cerebellar cortex enhances GABAergic transmission onto Purkinje cells
Scientific Reports, 2023 Ghrelin, an orexigenic peptide ligand for growth hormone secretagogue receptor 1a (GHS-R1a), occurs not only in the stomach but also in the brain, and modulates neuronal activity and synaptic efficacy.
Moritoshi Hirono, Masanori Nakata
doaj +1 more source
The level of KCNQ sets neural excitability.
, 2012 A–F. KCNQ is expressed in the motor neurons that were measured in the GCaMP3 experiments. Larvae containing a Gal4 enhancer trap (KCNQNP3423) in the KCNQ gene locus show high expression of KCNQ (labelled by membrane bound GFP in green, B and E) in the ...
James J. L. Hodge (116854) +2 more
core +1 more source
From Retigabine to Azetukalner: Reviving Voltage‐Gated Potassium Channels for Epilepsy Therapy
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.From the withdrawal of retigabine to the breakthrough of azetukalner, this review explores how rational redesign of KV7.2/3 potentiators overcame toxicity hurdles. We detail the synthesis, improved metabolic stability, and robust clinical outcomes in epilepsy, highlighting a new era of targeted potassium channel therapy. ABSTRACT Heterotetrameric KV7.2/
Pascal Rosendahl +2 more
wiley +1 more source
Cholesterol and Cholesterol‐Derived Molecules Differentially Modulate Neuronal Kv7.2/7.3 Channels
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Cholesterol, steroid hormones, and cholesterol‐based imidazolium salts (CHIMs) inhibit Kv7.2/Kv7.3 channels. Notably, NBD‐tagged CHIM‐L enhances currents. These findings demonstrate that both chemical modifications and linker length differentially modulate Kv7 activity, revealing variant‐specific sensitivities and potential pharmacological targets for ...
Elif Karabatak +6 more
wiley +1 more source