Results 81 to 90 of about 3,925 (184)

Die Untersuchung der menschlichen Kaliumkanalfamilie KCNQ im Modelltier Zebrafisch [PDF]

, 2010
Die Anzahl der Genmutationen, die mit bestimmten Erkrankungen in Verbindung gebracht werden, steigt kontinuierlich. Um die Funktion der betroffenen Gene und daher auch die Pathomechanismen, welche durch deren Mutationen ausgelöst werden, besser zu ...
Klier, Ina
core   +1 more source

An Open‐Source Pipeline for Calcium Imaging and All‐Optical Physiology in Human Stem Cell‐Derived Neurons

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This work introduces an open‐source all‐optical platform for functional phenotyping of human stem cell‐derived neurons. The system integrates optogenetics, calcium imaging, automated acquisition, and analysis to resolve single‐cell and network activity, enabling longitudinal measurements, disease modeling, and pharmacological screening in preclinical ...
Wardiya Afshar‐Saber, Federico M. Gasparoli, Ziqin Yang, Nicole A. Teaney, Rachel Hobson, Lahin Lalani, Gayathri Srinivasan, Dosh Whye, Ranit Karmakar, Elizabeth D. Buttermore, Kellen D. Winden, Cidi Chen, Mustafa Sahin   +12 more
wiley   +1 more source

KCNQ gene expression in the murine vasculature

The FASEB Journal, 2007
KCNQ2‐5 are considered to be only expressed by neurones. Ohya et al. (Circ Res., 92, –1023, 2003) showed that full length KCNQ1 and a C‐terminal truncated variant were expressed in murine portal vein (mPV), where it contributed to ...
Shuk Yin Yeung, Prashanth Sathiagnanam, James Moffatt, Vladimir Pucovsky, Iain Greenwood   +4 more
openaire   +1 more source

Small Molecule Investigation of KCNQ Potassium Channels: A Dissertation [PDF]

, 2012
Voltage-gated K+ channels associate with multiple regulatory proteins to form complexes with diverse gating properties and pharmacological sensitivities.
Mruk, Karen
core   +1 more source

KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Nature Communications, 2016
Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes ...
Allyson K. Friedman, Barbara Juarez, Stacy M. Ku, Hongxing Zhang, Rhodora C. Calizo, Jessica J. Walsh, Dipesh Chaudhury, Song Zhang, Angel Hawkins, David M. Dietz, James W. Murrough, Maria Ribadeneira, Erik H. Wong, Rachael L. Neve, Ming-Hu Han   +14 more
doaj   +1 more source

GABAergic Neuron Activation in the RMTg‐VTA Pathway Modulates Dopaminergic Neuron Excitability and Social Stress Susceptibility in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
In susceptible mice, dopamine neurons in the VTA exhibit increased excitability along with upregulation of GABAA receptors. Administration of the GABAA receptor agonist muscimol reduces this neuronal hyperexcitability and reverses social avoidance behavior.
Guang‐Yue Ma, Jin‐Zhu Zhuang, Shu‐Feng Li, Yu‐E Zhang, Di Zhang, Jun Zhao, Zhen Peng, Liu Yang, Zhang Cao, Xin Xie, Rong Jiang, Hui Sun   +11 more
wiley   +1 more source

Activation of peripheral KCNQ channels relieves gout pain [PDF]

Pain, 2015
Intense inflammatory pain caused by urate crystals in joints and other tissues is a major symptom of gout. Among therapy drugs that lower urate, benzbromarone (BBR), an inhibitor of urate transporters, is widely used because it is well tolerated and highly effective. We demonstrate that BBR is also an activator of voltage-gated KCNQ potassium channels.
Zheng, Yueming, Xu, Haiyan, Zhan, Li, Zhou, Xindi, Chen, Xueqin, Gao, Zhaobing   +5 more
openaire   +2 more sources

The function of KCNQ ion channels in pain and somatosensation

, 2016
Der durch KCNQ (Kv7) Kanäle vermittelte M-Strom spielt eine wichtige Rolle für elektrische Eigenschaften von Zellen. Als intrinsische Spannungsklemme stabilisieren KCNQ Kanäle demnach das Ruhemembranpotential und verhindern Übererregbarkeit, wie ...
Schütze, Sebastian
core   +1 more source

Visceral hyperalgesia induced by forebrain-specific suppression of native Kv7/KCNQ/M-current in mice

Molecular Pain, 2011
Background Dysfunction of brain-gut interaction is thought to underlie visceral hypersensitivity which causes unexplained abdominal pain syndromes.
Bian Xiling, Cao Xu, Su Jun, Chen Hui, Bi Yeping, Wang KeWei   +5 more
doaj   +1 more source

Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats

Molecular Pain, 2010
Background Temporomandibular disorders (TMDs) are characterized by persistent orofacial pain and have diverse etiologic factors that are not well understood.
Xu Wen, Wu Yuwei, Bi Yeping, Tan Lei, Gan Yehua, Wang KeWei   +5 more
doaj   +1 more source