Results 11 to 20 of about 32,637 (272)

Isoindolinone ureas: a novel class of KDR kinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2004
A series of substituted isoindolinone ureas was prepared and evaluated for enzymatic and cellular inhibition of KDR kinase activity. Several of these analogs, such as 14c, are potent inhibitors of KDR both enzymatically (< 50 nM) and cellularly < or = 100 nM).
Michael L, Curtin, Robin R, Frey, H Robin, Heyman, Kathy A, Sarris, Douglas H, Steinman, James H, Holmes, Peter F, Bousquet, George A, Cunha, Maria D, Moskey, Asma A, Ahmed, Lori J, Pease, Keith B, Glaser, Kent D, Stewart, Steven K, Davidsen, Michael R, Michaelides   +14 more
openaire   +3 more sources

Performance assessment of Bayesian meta-analytic predictive model on kdr mutation in insecticide-resistant malarial vectors in sub-Saharan Africa. [PDF]

Malar J
Ahuekwe EF, Taiwo DI.
europepmc   +3 more sources

Global Pattern of kdr-Type Alleles in Musca domestica (L.)

Current Tropical Medicine Reports, 2022
Purpose of Review Houseflies, Musca domestica L., are an important sanitary pest that affects human and domesticated animals. They are mechanical carriers of more than 100 human and animal diseases including protozoan, bacterial, helminthic, and viral ...
G. Roca-Acevedo, Ivana Boscaro, A. Toloza   +2 more
semanticscholar   +1 more source

First report of F1534C kdr mutation in deltamethrin resistant Aedes albopictus from northern part of West Bengal, India

Scientific Reports, 2022
Dengue is the most rapidly spreading vector-borne disease with an estimated 100–400 million cases each year. Control of Dengue vectors largely depends upon synthetic pyrethroids.
Manas Pratim Modak, Dhiraj Saha
semanticscholar   +1 more source

Multiple origins of kdr-type resistance in the house fly, Musca domestica. [PDF]

PLoS ONE, 2012
Insecticide resistance is a model phenotype that can be used to investigate evolutionary processes underlying the spread of alleles across a global landscape, while offering valuable insights into solving the problems that resistant pests present to ...
Frank D Rinkevich, Shannon M Hedtke, Cheryl A Leichter, Sarah A Harris, Cathy Su, Seán G Brady, Vatan Taskin, Xinghui Qiu, Jeffrey G Scott   +8 more
doaj   +1 more source

Fitness costs of individual and combined pyrethroid resistance mechanisms, kdr and CYP-mediated detoxification, in Aedes aegypti

PLoS Neglected Tropical Diseases, 2021
Background Aedes aegypti is an important vector of many human diseases and a serious threat to human health due to its wide geographic distribution and preference for human hosts. A.
L. Smith, Juan J Silva, Connie Chen, L. Harrington, J. G. Scott   +4 more
semanticscholar   +1 more source

Analysis of endothelial progenitor cell subtypes as clinical biomarkers for elderly patients with ischaemic stroke

Scientific Reports, 2023
Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133) and endothelial maturity (KDR), may determine the extent of post-stroke vascular repair.
Rais Reskiawan A. Kadir, Kamini Rakkar, Othman A. Othman, Nikola Sprigg, Philip M. Bath, Ulvi Bayraktutan   +5 more
doaj   +1 more source

Micro-Organ Chip Deciphers Tumor-Derived G-CSF as Remote Commander of Lung Pre-Metastatic Niche via VEGFA-KDR Cascade. [PDF]

Adv Sci (Weinh)
Breast cancer reprograms the lung into a receptive pre‐metastatic niche via a novel G‐CSF–VEGFA–KDR signaling axis. Using a micro‐organ chip that enables contact‐independent coculture, this study uncovers how tumor‐secreted G‐CSF activates lung capillary KDR to drive angiogenesis and prime the soil for metastasis—without direct tumor contact.
Zhang J, Huang X, Ma L, Chen Z, Li T, Wang L, Guo Y, Xu H, Li J, Qin JJ, Wang X, Cao Y, Miao K.   +12 more
europepmc   +2 more sources

Status of insecticide susceptibility in Anopheles arabiensis and detection of the knockdown resistance mutation (kdr) concerning agricultural practices from Northern Sudan state, Sudan

Journal of Genetic Engineering and Biotechnology, 2021
Background Chemical control has been the most efficient method in mosquito control, the development of insecticide resistance in target populations has a significant impact on vector control.
M. Y. Korti, T. B. Ageep, A. I. Adam, K. B. Shitta, A. A. Hassan, A. A. Algadam, R. M. Baleela, H. A. Saad, S. A. Abuelmaali   +8 more
doaj   +1 more source

Presence of L1014F Knockdown-Resistance Mutation in Anopheles gambiae s.s. From São Tomé and Príncipe

Frontiers in Cellular and Infection Microbiology, 2021
Malaria, one of the most serious parasitic diseases, kills thousands of people every year, especially in Africa. São Tomé and Príncipe are known to have stable transmission of malaria.
Hongying Zhang, Hongying Zhang, Mingqiang Li, Ruixiang Tan, Changsheng Deng, Changsheng Deng, Bo Huang, Zhibin Wu, Shaoqing Zheng, Wenfeng Guo, Wenfeng Guo, Fei Tuo, Yueming Yuan, Carlos Alberto Bandeira, D’almeida Herodes Rompão, Qin Xu, Qin Xu, Jianping Song, Jianping Song, Qi Wang, Qi Wang   +20 more
doaj   +1 more source