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Keratan Sulfate Biosynthesis [PDF]
IUBMB Life, 2002 AbstractKeratan sulfate was originally identified as the major glycosaminoglycan of cornea but is now known to modify at least a dozen different proteins in a wide variety of tissues. Despite a large body of research documenting keratan sulfate structure, and an increasing interest in the biological functions of keratan sulfate, until recently little ...
James L Funderburgh
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Keratan sulfate: An up-to-date review
International Journal of Biological Macromolecules, 2015Keratan sulfate (KS) is a glycosaminoglycan (GAG) type consisted of a sulfated poly-N-acetyl lactosamine chain. Besides acting as a constitutive molecule of the extracellular matrices, this GAG also plays a role as a hydrating and signaling agent in cornea and cartilage tissues. Inasmuch, KS is widely explored in the pharmaceutical industry.
Vitor H Pomin
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Synthesis of biotinylated keratan sulfate repeating disaccharides [PDF]
Bioscience, Biotechnology and Biochemistry, 2014 Abstract We synthesized four types of keratan and keratan sulfate repeating disaccharides containing non-sulfate, Galβ1-4GlcNAcβ, and three types of sulfates, Gal6Sβ1-4GlcNAcβ, Galβ1-4GlcNAc6Sβ, and Gal6Sβ1-4GlcNAc6Sβ in an efficient and stereo-controlled manner. These disaccharides were conjugated with biotin via a hydrophilic linker at
Jun-Ichi Tamura, Tamura Jun-Ichi
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Expression of low-sulfated keratan sulfate in non-mucinous ovarian carcinoma
Glycobiology, 2023Abstract Keratan sulfate glycosaminoglycan is composed of repeating N-acetyllactosamine (LacNAc) disaccharide units consisting of galactose (Gal) and N-acetylglucosamine (GlcNAc), both often 6-O-sulfated. Sulfate contents of keratan sulfate are heterogeneous depending upon the origins.
Kay-Hooi Khoo +2 more
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Immunoblotting Assays for Keratan Sulfate
Analytical Biochemistry, 2002The detection of microquantities of glycosaminoglycans (GAGs) in biological samples has been hampered by the lack of sensitive methods. In this paper we describe the modification and development of three sensitive assays capable of detecting nanogram quantities of GAGs in biological samples. The first assay detects total GAGs.
Jung Hae, Yoon +2 more
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Journal of Pharmaceutical and Biomedical Analysis, 2021
This study was designed to explore the sulfation patterns of chondroitin sulfate (CS)/dermatan sulfate (DS), and keratan sulfate (KS) and the expression of carbohydrate sulfotransferases (CHSTs) in 26 pancreatic tumor and normal tissues. CS/DS and KS profiles were simultaneously determined.
Qiang Ren, Chao Liu, Wei Qin
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This study was designed to explore the sulfation patterns of chondroitin sulfate (CS)/dermatan sulfate (DS), and keratan sulfate (KS) and the expression of carbohydrate sulfotransferases (CHSTs) in 26 pancreatic tumor and normal tissues. CS/DS and KS profiles were simultaneously determined.
Qiang Ren, Chao Liu, Wei Qin
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The Linkage of Corneal Keratan Sulfate to Protein
Connective Tissue Research, 1975The linkage of corneal keratan sulfate to protein has been investigated. After exhaustive digestion of bovine corneas with papain and pronase, a product was obtained in which aspartic acid was the predominant amino acid and constituted 59% of the total amino acids.
J R, Baker, J A, Cifonelli, L, Rodén
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Water vapor sorption of keratan sulfate
Molecular and Cellular Biochemistry, 1975Keratan sulfate was isolated from bovine cornea. The water vapor sorption isotherms were obtained on both sodium and calcium salts of keratan sulfate at different temperatures. Deuterated water sorption isotherms were obtained on sodium keratan sulfates.
B, Plessy, F A, Bettelheim
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Keratan sulfate in body fluids in joint disease
Acta Orthopaedica Scandinavica, 1995Keratan sulfate (KS) is a highly-negatively charged glycosaminoglycan which is found principally in aggrecan, the most abundant proteoglycan in the extracellular matrix of hyaline, fibrous and elastic cartilage. In 1985, we discovered that small peptidoglycans bearing antigenic KS (agKS) were present in small amounts in human serum and postulated that ...
Thonar, Eugene J-M A +5 more
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