Results 21 to 30 of about 55,822 (247)

Keratin 19 expression correlates with poor prognosis in breast cancer [PDF]

Molecular Biology Reports, 2014
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression.
Kabir, Nuzhat N., Rönnstrand, Lars, Kazi, Julhash U.   +2 more
openaire   +3 more sources

HNRNPK is retained in the cytoplasm by Keratin 19 to stabilize target mRNAs [PDF]

, 2022
Abstract Heterogeneous nuclear ribonucleoprotein K (HNRNPK) regulates pre-mRNA processing and long non-coding RNA localization in the nucleus. It was previously shown that shuttling of HNRNPK to the cytoplasm promotes cell proliferation and cancer metastasis. However, the mechanism of HNRNPK cytoplasmic localization, its cytoplasmic RNA
Arwa Fallatah, Dimitrios G. Anastasakis, Amirhossein Manzourolajdad, Pooja Sharma, Xiantao Wang, Alexis Jacob, Sarah Alsharif, Ahmed Elgerbi, Pierre A. Coulombe, Markus Hafner, Byung Min Chung   +10 more
openaire   +1 more source

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma [PDF]

Clinical Cancer Research, 2015
Abstract Purpose: Keratin 19 (K19) is a known marker of poor prognosis and invasion in human hepatocellular carcinoma (HCC). However, the relationship between K19 and cancer stem cells (CSCs) is unclear. Here, we determined whether K19 can be used as a new CSC marker and therapeutic target in HCC. Experimental Design:
Takayuki, Kawai, Kentaro, Yasuchika, Takamichi, Ishii, Hokahiro, Katayama, Elena Yukie, Yoshitoshi, Satoshi, Ogiso, Sadahiko, Kita, Katsutaro, Yasuda, Ken, Fukumitsu, Masaki, Mizumoto, Etsuro, Hatano, Shinji, Uemoto   +11 more
openaire   +2 more sources

An Integrative Bioinformatic Analysis for Keratinase Detection in Marine-Derived Streptomyces

Marine Drugs, 2021
Keratinases present promising biotechnological applications, due to their ability to degrade keratin. Streptomyces appears as one of the main sources of these enzymes, but complete genome sequences of keratinolytic bacteria are still limited.
Ricardo Valencia, Valentina González, Agustina Undabarrena, Leonardo Zamora-Leiva, Juan A. Ugalde, Beatriz Cámara   +5 more
doaj   +1 more source

Heterogeneity of Epigenetic and Epithelial Mesenchymal Transition Marks in Hepatocellular Carcinoma with Keratin 19 Proficiency. [PDF]

Liver Cancer, 2019
<b><i>Objective:</i></b> Keratin 19 (K19) expression is a potential predictor of poor prognosis in patients with hepatocellular carcinoma (HCC). To clarify the feature of K19-proficient HCC, we traced epigenetic footprints in cultured cells and clinical materials.
Yokomichi N, Nishida N, Umeda Y, Taniguchi F, Yasui K, Toshima T, Mori Y, Nyuya A, Tanaka T, Yamada T, Yagi T, Fujiwara T, Yamaguchi Y, Goel A, Kudo M, Nagasaka T.   +15 more
europepmc   +4 more sources

Blackcurrant Extract with Phytoestrogen Activity Alleviates Hair Loss in Ovariectomized Rats

Molecules, 2019
Ancocyanin-rich blackcurrant extract (BCE) has phytoestrogen activity; however, its effect on hair follicles is unknown. Additionally, hair loss is known to occur during menopause in women owing to decreased estrogen secretion.
Naoki Nanashima, Kayo Horie
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

The Adjuvant Therapy Influence upon Micrometastasis in Bone Marrow Aspiration and Detection of Relapse Rate in Breast Cancer Patients Follow up [PDF]

International Journal of Hematology-Oncology and Stem Cell Research, 2010
"nIntroduction: Breast cancers in the early phase frequently undergo distant metastasis and survival of patients is greatly dependent on distant metastasis.
Mozafar Aznab, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Seyed Hamidollah Ghaffari, Shahrbanou Roostami   +4 more
doaj   +2 more sources

The Tumor Markers Tpa, Tps, Tpa and Cyfra 21–1 React Differently with the Keratins 8, 18 and 19

The International Journal of Biological Markers, 1994
The commercially available tumor marker tests TPA, TPS, TPA CYK and CYFRA 21–1 react with simple epithelium keratins. From clinical studies it can be deduced that the pattern of keratin recognition must be different for each of these tests.
H. Bodenmüller, F. Donié, M. Kaufmann, D. Banauch   +3 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source