Results 11 to 20 of about 8,643,049 (268)
Keratin 19 expression correlates with poor prognosis in breast cancer [PDF]
Molecular Biology Reports, 2014 Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression.
Nuzhat N. Kabir +2 more
semanticscholar +4 more sources
Morphology, Motility, and Cytoskeletal Architecture of Breast Cancer Cells Depend on Keratin 19 and Substrate [PDF]
Cytometry Part A, 2020 Cancer cells gain motility through events that accompany modulation of cell shape and include altered expression of keratins. However, the role of keratins in change of cancer cell architecture is not well understood. Therefore, we ablated the expression
Van Lam +5 more
semanticscholar +3 more sources
Keratin 19 is a potential diagnostic and prognostic biomarker in pancreatic adenocarcinoma
MedicineThis study aimed to evaluate Keratin 19 (KRT19) as a potential prognostic biomarker for the diagnosis and prognosis of pancreatic adenocarcinoma (PAAD). Using data from The Cancer Genome Atlas and the Gene Expression Omnibus, we analyzed KRT19 expression
Ling He, Li Li, Zhiqiang Chen
semanticscholar +3 more sources
BMC Medicine, 2020 Background Keratins (Ks) represent tissue-specific proteins. K18 is produced in hepatocytes while K19, the most widely used ductular reaction (DR) marker, is found in cholangiocytes and hepatic progenitor cells.
Karim Hamesch +16 more
doaj +2 more sources
Keratin 19 im Verdauungssystem
, 2018 Keratine stellen Intermediärfilamente der Epithelzellen dar. K19 gehört mit K7, K8, K18 und K20 zu den Keratinen der einschichtigen Epithelien. In der Leber wird es in den Gallengangepithelien und hepatischen Stammzellen, nicht aber in adulten Hepatozyten exprimiert.
Manuela Spurny
semanticscholar +3 more sources
Influences of Desmin and Keratin 19 on Passive Biomechanical Properties of Mouse Skeletal Muscle [PDF]
Journal of Biomedicine and Biotechnology, 2012 In skeletal muscle fibers, forces must be transmitted between the plasma membrane and the intracellular contractile lattice, and within this lattice between adjacent myofibrils. Based on their prevalence, biomechanical properties and localization, desmin
Sameer B. Shah +4 more
semanticscholar +3 more sources
Keratin 19 protein expression is an independent predictor of survival in human hepatocellular carcinoma [PDF]
European Journal of Gastroenterology & Hepatology, 2015 We aimed to assess the clinicopathological relevance and prognostic significance of expression of the hepatic progenitor cell markers keratin 19 (K19), epithelial cell adhesion molecule (EpCAM) and CD117 (c-KIT) in a White series of hepatocellular carcinoma (HCC).We evaluated the immunohistochemical expression of K19, EpCAM and CD117 in 89 surgical ...
E. Fatourou +10 more
semanticscholar +5 more sources
Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin [PDF]
Experimental Dermatology, 2014 SIRT2 is a member of the mammalian sirtuin family (SIRT1‐7). As compared with other sirtuins, SIRT2 is found primarily in the cytoplasm. It regulates multiple physiological processes.
Ming Mei +3 more
semanticscholar +3 more sources
BMC Cancer, 2017 Background The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis.
KyuHo Lee +6 more
doaj +2 more sources
BMC Cancer, 2016 Keratin (K) 19-positive hepatocellular carcinoma (HCC) is well known to have a higher malignant potential than K19-negative HCC: However, the molecular mechanisms involved in K19-mediated progression of HCC remain unclear. We attempted to clarify whether
M. Takano +8 more
semanticscholar +3 more sources