Results 121 to 130 of about 57,590 (253)

Loss of Keratin 19 predisposes to the development of cholestatic liver disease

open access: yes, 2014
Keratins (K) are cytoprotective proteins and keratin mutations predispose to development of multiple human diseases. K19 represents the most widely used biliary and liver progenitor cell (LPC) marker. Since K19 variants were found in patients with primary biliary cirrhosis (PBC), we investigated the role of K19 in cholangiocytes and LPCs. K19 wild-type
openaire   +2 more sources

Global Multidisciplinary Variation in Idiopathic Subglottic Stenosis Surgical Management

open access: yesThe Laryngoscope, EarlyView.
This international cross‐sectional survey of 193 clinicians across 42 countries reveals substantial global and multidisciplinary variation in the surgical management of idiopathic subglottic stenosis (iSGS). While endoscopic dilation remains near‐universally utilized, practice patterns differ significantly regarding technical execution, adjuvant ...
Emilie A. C. Dronkers   +7 more
wiley   +1 more source

High keratinase and other types of hydrolase activity of the new strain of Bacillus paralicheniformis.

open access: yesPLoS ONE
Keratinases, a subclass of proteases, are used to degrade keratin thereby forming peptones and free amino acids. Bacillus paralicheniformis strain T7 was isolated from soil and exhibited high keratinase, protease, collagenase, amylase, xylanase, lipase ...
Saniya Aktayeva, Bekbolat Khassenov
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Spatial transcriptomics reveals club cell features and strong CLDN18 expression along the mucinous pathway to invasive mucinous adenocarcinoma

open access: yesThe Journal of Pathology, EarlyView.
Abstract Invasive mucinous adenocarcinoma (IMA) of the lung is a distinct subtype of lung adenocarcinoma with unique clinicopathologic features; however, its histogenesis remains incompletely understood. Although mucinous metaplasia has been suspected as a precursor lesion, direct molecular evidence supporting this progression is limited. In this study,
Joon Young Park   +5 more
wiley   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar   +3 more
wiley   +1 more source

Cytokeratin expression in breast cancer: from mechanisms, progression, diagnosis, and prognosis to therapeutic implications

open access: yesMolecular & Cellular Oncology
Background and Aim Cytokeratins (CKs) are structural proteins vital to epithelial integrity and play key roles in breast cancer progression. This review explores their expression, functions, and therapeutic potential.Methods A systematic review was ...
Ensiyeh Bahadoran   +8 more
doaj   +1 more source

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